volume 73, issue 4, P496-504 2021
DOI: 10.1093/jpp/rgaa049
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Cynthia Maria C Pereira, Genilson José Dias Júnior, José Victor do N Lima, Sarah Izabelly Alves Lemos, Lauanda da Rocha Rodrigues, Jayro dos Santos Ferreira, Anna Sofia Miranda Loiola Araújo, Joveline Costa de Oliveira, Carlos Eduardo Monteiro, Álvaro Xavier Franco, Even Herlany Pereira Alves, Francisca Géssica Oliveira Silva, Marcelo de Carvalho Filgueiras, Pedro M G Soares et al.

Abstract: Abstract Objective To evaluate the participation of the phosphatidylinositol 3-kinase pathway in the liver damage caused by nimesulide. Methods Liver damage been induced by nimesulide. Mice were treated with either 2% dimethyl sulfoxide or AS605240, a phosphatidylinositol 3-kinase gamma pathway antagonist. Blood samples were collected for function assays of liver. The liver was removed for an…

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