Phosphatidylinositol-3-kinase and protein kinase C are involved in the pro-cognitive and anti-anxiety effects of phytohormone abscisic acid in rats

Naderi, Reyhaneh; Esmaeili‐Mahani, Saeed; Abbasnejad, Mehdi

doi:10.1016/j.biopha.2017.09.089

Cited by 20 publications

(24 citation statements)

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“…However, there were no statistically significant differences in reaction to heat stimulus between groups in the rest of the time course experiment. It is already indicated ABA physiological effects are achieved in a concentration-dependent manner 11,37 . Spatially, our last studies indicated that the central microinjection of ABA (10 µg/rat) is enough to improve spatial learning and memory performances and to suppress thermal and inflammatory nociception in adult male rats 11,13 .…”

Section: Discussionmentioning

confidence: 99%

“…It is already indicated ABA physiological effects are achieved in a concentration-dependent manner 11,37 . Spatially, our last studies indicated that the central microinjection of ABA (10 µg/rat) is enough to improve spatial learning and memory performances and to suppress thermal and inflammatory nociception in adult male rats 11,13 . In the present study, to find the most effective dose of ABA for preventing nociception, we also administrated ABA 20 µg/rat, which surprisingly had no different effects from that of ABA at the dose 10 µg/rat.…”

Section: Discussionmentioning

confidence: 99%

“…Plant and animal studies showed that ABA recruits a very wide spectrum of signaling pathways, such as: peroxisome proliferator-activated receptors (PPARs), lanthioninesynthetase C-like protein 2 (LANCL2), and several protein kinase, including PKA, PKC and phosphatidylinositol 3-Kinase 9,10 . Recently, Naderi et al reported that central microinjection of ABA improves cognitive functions and exhibits antianxiety effects with PKC and PI3 kinase signaling pathways 11 . ABA-induced insulin releasing effect, as one of the important and remarkable effects of ABA, is performed with PKA signaling 12 .…”

Section: Spinal Protein Kinase a And Phosphorylated Extracellular Sigmentioning

confidence: 99%

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Spinal protein kinase A and phosphorylated extracellular signal-regulated kinase signaling are involved in the antinociceptive effect of phytohormone abscisic acid in rats

Mollashahi

Abbasnejad

Esmaeili‐Mahani

2020

Arq. Neuro-Psiquiatr.

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Objective: The phytohormone abscisic acid (ABA) as a signaling molecule exists in various types of organisms from early multicellular to animal cells and tissues. It has been demonstrated that ABA has an antinociceptive effect in rodents. The present study was designed to assess the possible role of PKA and phosphorylated ERK (p-ERK) on the antinociceptive effects of intrathecal (i.t.) ABA in male Wistar rats. Methods: The animals were cannulated intrathecally and divided into different experimental groups (n=6‒7): Control (no surgery), vehicle (received ABA vehicle), ABA-treated groups (received ABA in doses of 10 or 20 µg/rat), ABA plus H.89 (PKA inhibitor)-treated group which received the inhibitor 15 min prior to the ABA injection. Tail-flick and hot-plate tests were used as acute nociceptive stimulators to assess ABA analgesic effects. p-ERK was evaluated in the dorsal portion of the spinal cord using immunoblotting. Results: Data showed that a microinjection of ABA (10 and 20 µg/rat, i.t.) significantly increased the nociceptive threshold in tail flick and hot plate tests. The application of PKA inhibitor (H.89, 100 nM/rat) significantly inhibited ABA-induced analgesic effects. Expression of p-ERK was significantly decreased in ABA-injected animals, which were not observed in the ABA+H.89-treated group. Conclusions: Overall, i.t. administration of ABA (10 µg/rat) induced analgesia and p-ERK down-expression likely by involving the PKA-dependent mechanism.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Spinal Protein Kinase a And Phosphorylated Extracellular Sigmentioning

confidence: 99%

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Spinal protein kinase A and phosphorylated extracellular signal-regulated kinase signaling are involved in the antinociceptive effect of phytohormone abscisic acid in rats

Mollashahi

Abbasnejad

Esmaeili‐Mahani

2020

Arq. Neuro-Psiquiatr.

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“…The presence of ABA in the brain tissues of rats and pigs has been reported in 1986 ( Le Page-Degivry et al, 1986 ). It has been indicated that exogenous administration of ABA improves learning capability and mood state of rats ( Qi et al, 2014 , 2015 ; Naderi et al, 2017 ). So, it may be a potential therapeutic molecule of memory enhancer, which could be used in memory deficits disease, e.g., Alzheimer disease, in future study.…”

Section: Discussionmentioning

confidence: 99%

“…As a direct derivative of carotenoids, ABA and all- trans retinoic acid share a similar molecular structure, with a free carboxyl group at the end of the isoprene composed side-chain, which is the critical part of their bioactivity ( Walker-Simmons et al, 1991 ; Moise et al, 2005 ). And retinoic acid ( Vershinin, 1999 ; Nambara and Marion-Poll, 2005 ) as well as ABA ( Qi et al, 2015 ; Naderi et al, 2017 ) has been reported to improve learning and memory and anxiety-like behavior.…”

Section: Introductionmentioning

confidence: 99%

Phytohormone Abscisic Acid Improves Spatial Memory and Synaptogenesis Involving NDR1/2 Kinase in Rats

Liu

Zou

et al. 2018

Front. Pharmacol.

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The abscisic acid (ABA) is a phytohormone involved in plant growth, development and environmental stress response. Recent study showed ABA can also be detected in other organisms, including mammals. And it has been reported that ABA can improve learning and memory in rats. In this study, we attempted to investigate the effects of ABA on the alternation of dendritic spine morphology of pyramidal neurons in developmental rats, which may underlie the learning and memory function. Behavior tests showed that ABA significantly improved spatial memory performance. Meanwhile, Golgi-Cox staining assay showed that ABA significantly increased the spine density and the percentage of mushroom-like spines in pyramidal neurons of hippocampus, indicating that ABA increased dendritic spine formation and maturation, which may contribute to the improvement of spatial memory. Furthermore, ABA administration increased the protein expression of NDR1/2 kinase, as well as mRNA levels of NDR2 and its substrate Rabin8. In addition, NDR1/2 shRNA prohibited the ABA-induced increases in the expression of NDR1/2 and spine density. Together, our study indicated that ABA could improve learning and memory in rats and the effect are possibly through the regulation of synaptogenesis, which is mediated via NDR1/2 kinase pathway.

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Phytohormone abscisic acid elicits positive effects on harmaline‐induced cognitive and motor disturbances in a rat model of essential tremor

Shabani

Naderi

2022

Brain and Behavior

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Objective Essential tremor (ET) as a neurological disorder is accompanied by cognitive and motor disturbances. Despite the high incidence of ET, the drug treatment of ET remains unsatisfactory. Recently, abscisic acid (ABA) has been reported to have positive neurophysiological effects in mammals. Here, the effects of ABA on harmaline‐induced motor and cognitive impairments were investigated in rats. Methods Male Wistar rats weighing 120–140 g were divided into control, harmaline (30 mg/kg, ip), ABA vehicle (DMSO+normal saline), and ABA (10 μg/rat, icv, 30 min before harmaline injection) groups. Exploratory, balance and motor performance, anxiety, and cognitive function were assessed using footprint, open field, wire grip, rotarod, and shuttle box tests. Results The results indicated that ABA (10 μg/rat) can improve harmaline‐induced tremor in rats. The administration of ABA significantly increased time spent on wire grip and rotarod. In addition, ABA had a promising effect against the cognitive impairments induced by harmaline. Conclusion Taken together, ABA has positive effects on locomotor and cognitive impairments induced by tremor. However, further studies are required to determine the exact mechanisms of ABA on the ET.

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Phosphatidylinositol-3-kinase and protein kinase C are involved in the pro-cognitive and anti-anxiety effects of phytohormone abscisic acid in rats

Cited by 20 publications

References 50 publications

Spinal protein kinase A and phosphorylated extracellular signal-regulated kinase signaling are involved in the antinociceptive effect of phytohormone abscisic acid in rats

Spinal protein kinase A and phosphorylated extracellular signal-regulated kinase signaling are involved in the antinociceptive effect of phytohormone abscisic acid in rats

Phytohormone Abscisic Acid Improves Spatial Memory and Synaptogenesis Involving NDR1/2 Kinase in Rats

Phytohormone abscisic acid elicits positive effects on harmaline‐induced cognitive and motor disturbances in a rat model of essential tremor

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