Phosphatidylcholine content and fatty acid composition of tracheal and gastric liquids from premature and fullterm newborn infants

Motoyama, Etsuro K.; Namba, Y.; Rooney, Seamus A.

doi:10.1016/0009-8981(76)90358-2

Cited by 15 publications

(6 citation statements)

References 23 publications

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“…Table 1 also shows that the fatty acid composition of lecithins form gastric and tracheal aspirates and amniotic fluid were similar. This finding confirms the report of Motoyama et al (23) in respect to the similarity of lecithins from gastric and tracheal liquids. Our results differ from those of these latter authors (23), in that the concentration of palmitic acid in the lecithins of gastric aspirates from healthy premature infants was not significantly lower, and in that stearate levels were not higher in these subjects than in full term control subjects ( Table 2).…”

Section: Discussionsupporting

confidence: 93%

“…This finding confirms the report of Motoyama et al (23) in respect to the similarity of lecithins from gastric and tracheal liquids. Our results differ from those of these latter authors (23), in that the concentration of palmitic acid in the lecithins of gastric aspirates from healthy premature infants was not significantly lower, and in that stearate levels were not higher in these subjects than in full term control subjects ( Table 2). Frantz et al (16) stressed the importance of increased concentrations of stearic acid in lecithins of amniotic fluid in premature infants as a predictor of RDS.…”

Section: Discussionsupporting

confidence: 93%

“…The findings are consistent with those of Frantz et al (16) based on studies of amniotic fluid, but extend them to gastric aspirates. Motoyama et al (23) reported that one infant who developed IRDS had only 30% palmitate in the lecithin of the gastric fluid. Thus, our observations validate this preliminary report.…”

Section: Discussionmentioning

confidence: 99%

“…Gastric aspirates are obtained routinely from infants at the time The enzyme systems involved in the biosynthesis of pulmonary of delivery in our institution, as in some others (23). It has been surfactant are complex.…”

Section: Speculationmentioning

confidence: 99%

“…All other samples were extracted without prior centrifugation in chloroform-methanol (15). Samples of gastric and tracheal aspirates were not centrifuged before extraction since preliminary studies showed, as previously reported by others (23), that this was not necessary. Phospholipids were separated on thin layer plates of silica gel (5) and quantified by determination of lipid phosphorus (6).…”

Section: Speculationmentioning

confidence: 99%

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Surfactant Lecithin Fatty Acid Composition and Its Relationship to the Infantile Respiratory Distress Syndrome

et al. 1978

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In order to evaluate the role of surfactant lecithin composition in the development of the infantile respiratory distress syndrome (IRDS) we have examined lecithin fatty acid composition from gastric aspirates obtained at the time of delivery from 14 full term healthy infants, 9 control premature infants without respiratory distress, and 16 premature infants who developed IRDS. The latter had significantly reduced concentrations of palmitic acid (48.4 +/- 1.8% vs. 65.3 +/- 1.5% in fullterm and 59.5 +/- 0.8% in control premature infants, P less than 0.001). None of the infants in whom palmitic acid was more than 60% of total lecithin fatty acids developed IRDS, whereas 10 of 11 infants with values below 50% did develop this complication. Lecithin from gastric aspirate was shown to be similar in fatty acid composition to lecithins from tracheal washings and amniotic fluid. Palmitic acid concentrations in lecithins of serial tracheal washings paralleled the clinical course of eight infants with IRDS.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Speculationmentioning

confidence: 99%

Section: Speculationmentioning

confidence: 99%

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Surfactant Lecithin Fatty Acid Composition and Its Relationship to the Infantile Respiratory Distress Syndrome

et al. 1978

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The Surfactant System of the Lung

Rooney¹

1985

Toxicology of Inhaled Materials

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Alveolar lavage and lavaged lung tissue phosphatidylcholine composition during fetal rabbit development

Rooney

Gobran

1977

Lipids

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Pulmonary surfactant, the major surface-active component of which in the adult is dipalmitoylglycerophosphocholine, can be obtained by lavaging lungs with physiological saline. We have previously shown that there is an increase in the amount of phosphatidylcholine in fetal rabbit lung lavage during the latter part of gestation. We have now measured the amount of disaturated phosphatidylcholine as well as the fatty acid composition of phosphatidylcholine in lung lavage from fetal rabbits during the period 27 days' gestation to full term (31 days). There was no developmental change in the amount of disaturated phosphatidylcholine during the period examined. About 50% of the total phosphatidylcholine was disaturated which is approximately the same as in adult rabbit lung lavage. The fatty acid composition, however, did change. There was an increase in the amount of 16:0 from about 20% of the total fatty acids in phosphatidylcholine at 27-28 days to about 60% at full term, after birth, and in the adults. There was a corresponding decrease in the amounts of 14:0, 18:0, and longer chain fatty acids, most of which were saturated. In the lavaged lung tissue, there was a 2.6-fold increase in the percentage of phosphatidylcholine which was disaturated during the period 27-31 days' gestation. It had not decrease to the adult value 24 hr after birth.

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Phosphatidylcholine content and fatty acid composition of tracheal and gastric liquids from premature and fullterm newborn infants

Cited by 15 publications

References 23 publications

Surfactant Lecithin Fatty Acid Composition and Its Relationship to the Infantile Respiratory Distress Syndrome

Surfactant Lecithin Fatty Acid Composition and Its Relationship to the Infantile Respiratory Distress Syndrome

The Surfactant System of the Lung

Alveolar lavage and lavaged lung tissue phosphatidylcholine composition during fetal rabbit development

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