Phosphatidyl Inositol 4-Kinases

Abstract

In recent decades, phosphoinositides (or PIs) have emerged as essential signaling molecules. Despite their low cellular abundance, PIs are found to be involved in various cellular processes, including cell migration, vesicular trafficking, cell cycle regulation, metabolism, cytoskeletal remodeling, autophagy, aging, apoptosis, and cell signaling. Recent studies have shown that aberrant activity of either lipid kinases or phosphatases leads to various medical implications like cancer, diabetes, and microbial infections, suggesting an essential role for these lipid molecules and enzymes in their metabolism. This entry focused on one of the critical enzymes involved in phosphoinositide metabolism: phosphatidyl inositol 4-kinase (PI4-Kinase).