Phosphatidic acid phospholipase A1 mediates ER–Golgi transit of a family of G protein–coupled receptors

Govind, Kunduri; Yuan, Changqing; Parthibane, Velayoudame; Nyswaner, Katherine M.; Kanwar, Ritu; Nagashima, Kunio; Britt, Steven G.; Mehta, Nickita; Kotu, Varshika; Porterfield, Mindy; Tiemeyer, Michael; Dolph, Patrick J.; Acharya, Usha; Acharya, Jairaj

doi:10.1083/jcb.201405020

Cited by 23 publications

(25 citation statements)

References 55 publications

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“…3a) than tester females mated with control males, indicating that the gene has a male-specific role in inducing female ovulation. In line with the previously described requirement of PAPLA1 for spermatogenesis23, hatchability of eggs laid by the tester females mated to PAPLA1 mutants was significantly decreased, too (Fig. 3b).…”

Section: Resultssupporting

confidence: 90%

“…In addition, testes of the PAPLA1 deficient males were smaller as well (Fig. 3c), as reported previously23, suggesting a general role of PAPLA1 in the development of male reproductive tract.…”

Section: Resultssupporting

confidence: 89%

“…Altogether, our work revealed novel roles of PAPLA1 in Drosophila reproduction; in addition to its known role in spermatogenesis23, male PAPLA1 is required also for proper development of accessory glands, and for male ability to induce female ovulation upon mating. In female reproduction, PAPLA1 is required for both oogenesis rate and viability of the produced egg.…”

Section: Resultsmentioning

confidence: 79%

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Spastic paraplegia-linked phospholipase PAPLA1 is necessary for development, reproduction, and energy metabolism in Drosophila

Gáliková

Klepsatel

Münch

et al. 2017

Sci Rep

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The human PAPLA1 phospholipase family is associated with hereditary spastic paraplegia (HSP), a neurodegenerative syndrome characterized by progressive spasticity and weakness of the lower limbs. Taking advantage of a new Drosophila PAPLA1 mutant, we describe here novel functions of this phospholipase family in fly development, reproduction, and energy metabolism. Loss of Drosophila PAPLA1 reduces egg hatchability, pre-adult viability, developmental speed, and impairs reproductive functions of both males and females. In addition, our work describes novel metabolic roles of PAPLA1, manifested as decreased food intake, lower energy expenditure, and reduced ATP levels of the mutants. Moreover, PAPLA1 has an important role in the glycogen metabolism, being required for expression of several regulators of carbohydrate metabolism and for glycogen storage. In contrast, global loss of PAPLA1 does not affect fat reserves in adult flies. Interestingly, several of the PAPLA1 phenotypes in fly are reminiscent of symptoms described in some HSP patients, suggesting evolutionary conserved functions of PAPLA1 family in the affected processes. Altogether, this work reveals novel physiological functions of PAPLA1, which are likely evolutionary conserved from flies to humans.

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Section: Resultssupporting

confidence: 90%

Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 79%

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Spastic paraplegia-linked phospholipase PAPLA1 is necessary for development, reproduction, and energy metabolism in Drosophila

Gáliková

Klepsatel

Münch

et al. 2017

Sci Rep

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“…44 While the mechanism of COPII assembly is unclear for vertebrate rhodopsin, COPII assembly can be specifically mediated by cytosolic phosphatidic acid phospholipase A1 (PAPLA1) in drosophila, which binds to both rhodopsin and COPII. 45 Other GPCRs appear to use the same mechanism for COPII assembly and ER exit. For this assembly, phospholipase activity of PAPLA1 is not essential.…”

Section: Biogenesis Of Rhodopsin In Endoplasmic Reticulum and Subsequmentioning

confidence: 97%

“…For this assembly, phospholipase activity of PAPLA1 is not essential. 45 As vertebrates also contain homologs of drosophila PAPLA1, it would be intriguing to test the roles of these homologs in the trafficking of vertebrate rhodopsin.…”

Section: Biogenesis Of Rhodopsin In Endoplasmic Reticulum and Subsequmentioning

confidence: 99%

Rhodopsin Trafficking and Mistrafficking

Nemet

Ropelewski

Imanishi

2015

Progress in Molecular Biology and Translational Science

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Impact of phospholipases on stem cell proliferation, differentiation, and therapy

Showket,

Dar,

Badesra

et al. 2023

Phospholipases in Physiology and Pathology

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Phosphatidic acid phospholipase A1 mediates ER–Golgi transit of a family of G protein–coupled receptors

Abstract: Cytosolic phosphatidic acid phospholipase A1 interacts with COPII protein family members and is required for the anterograde trafficking of GPCRs.

Cited by 23 publications

References 55 publications

Spastic paraplegia-linked phospholipase PAPLA1 is necessary for development, reproduction, and energy metabolism in Drosophila

Spastic paraplegia-linked phospholipase PAPLA1 is necessary for development, reproduction, and energy metabolism in Drosophila

Rhodopsin Trafficking and Mistrafficking

Impact of phospholipases on stem cell proliferation, differentiation, and therapy

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