2002
DOI: 10.1006/bioo.2001.1232
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Phosphates, DNA, and the Search for Nonterrean Life: A Second Generation Model for Genetic Molecules

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Cited by 117 publications
(77 citation statements)
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“…With few exceptions (van Mooy et al 2009), diacyl membrane lipids contain phosphate head groups, even though amphiphilic molecules that form bilayer membranes do not require the presence of phosphate (Israelachvili 1991;Evans and Wennerstrom 1999). Indeed, the importance of phosphate is a recurring theme in biology, with examples in lipids, nucleic acids (Benner and Hutter 2002), metabolism (Westheimer 1987;Deamer 1997), and cellular signaling (Tarrant and Cole 2009). …”
Section: Background Membrane Structurementioning
confidence: 99%
“…With few exceptions (van Mooy et al 2009), diacyl membrane lipids contain phosphate head groups, even though amphiphilic molecules that form bilayer membranes do not require the presence of phosphate (Israelachvili 1991;Evans and Wennerstrom 1999). Indeed, the importance of phosphate is a recurring theme in biology, with examples in lipids, nucleic acids (Benner and Hutter 2002), metabolism (Westheimer 1987;Deamer 1997), and cellular signaling (Tarrant and Cole 2009). …”
Section: Background Membrane Structurementioning
confidence: 99%
“…Even though macromolecular nucleic information may be organized in a vast number of alternative structures [7][8][9][10] extant nucleic acids have no natural substitutes. This very fact points to the relevance of the problems related to the origin and to the stability of their constituents.…”
Section: Open Accessmentioning
confidence: 99%
“…Benner has hypothesised that a uniform charge pattern in the backbone is not only crucial to prevent longer nucleic acid strands from folding, but that the repeating anionic motifs are also important for the molecular recognition of two native nucleic acid strands with complementary base sequences. 17,18 It is therefore of major importance to study whether oligonucleotides with zwitterionic backbones can still form stable duplex structures and retain base pairing fidelity.…”
mentioning
confidence: 99%