Phosphate starvation and membrane lipid remodeling in seed plants

Nakamura, Yuki

doi:10.1016/j.plipres.2012.07.002

Cited by 167 publications

(153 citation statements)

References 85 publications

Supporting

Mentioning

146

Contrasting

Unclassified

Order By: Relevance

“…5 Their presence in these photosynthetic organisms seems related to conditions of reduced phosphorous availability in which they replace phospholipids for their biological functions. 4,6 GlcADGs 20 participate to this lipid remodelling as the better-known anionic sulfolipids, sulfoquinovosyldiacylglycerols (SQDGs, figure 1), 7,8 sharing also the same biosynthetic pathway, which requires a common SQDG synthase. 4 Differently from GlcADGs, in the last years both natural and synthetic sulfoquinovosylacylglycerols 25 have been tested for their antitumor, antiviral, anti-inflammatory, immunosuppressive and other bioactivities.…”

Section: Introductionmentioning

confidence: 99%

Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt

et al. 2015

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Pi incorporated in lipid membranes also represents an abundant and readily available source. Shortly after the onset of Pi deficiency, nutrient starvation leads to the replacement of phosphoglycerolipids, such as phosphatidyl-choline (PtdCho) and phosphatidyl-ethanolamine (PtdEth), by sulfolipids (sulfoquinovosyldiacylglycerol) and galactolipids (digalactosyldiacylglycerol) within the membranes (Misson et al, 2005;Nakamura, 2013;Siebers et al, 2015). The two latter lipid forms are devoid of Pi, which allows the cell to recycle this element into other pathways that require Pi.…”

mentioning

confidence: 99%

“…For instance, SQD1 and SQD2 are involved in sulfolipid biosynthesis, whereas MGD2 and MGD3 are strongly induced to increase galactolipid content (Yu et al, 2002;Jouhet et al, 2004;Nakamura et al, 2005;Kobayashi et al, 2009). To achieve these substitutions, phospholipids are degraded by different types of lipases, resulting in the release of lipid subcomponents that can reenter the metabolism or be converted into other lipid forms (Nakamura, 2013).The Pi starvation-induced reprogramming of architecture and metabolism is supported by vast changes in the plant transcriptome and has been demonstrated in several plant models (Wasaki et al, 2003;Chiou and Lin, 2011;Hu and Chu, 2011;Huang et al, 2011). In Arabidopsis, more than 600 genes are induced in response to Pi starvation (Misson et al, 2005;Thibaud et al, 2010).…”

mentioning

confidence: 99%

“…However, the double KO pldz1 pldz2 contradicted these results since it did not exhibit any root hair alteration (Li et al, 2006). These conflicting results resemble our attempts to reproduce the root hair phenotype described previously for ppspase1 mutants and suggest either that these phenotypes were fortuitous or that there could be another unidentified factor controlling the link between root hair formation and choline, PCho, or PtdCho contents.The lack of architectural modification could also be explained by the fact that several independent pathways can lead to lipid degradation during Pi starvation, through phospholipase D (PLD), phosphatidate phosphatase (PAP), phospholipase C (PLC), or other types of transferases (Nakamura, 2013;Meï et al, 2017). In addition, de novo glycerolipid biosynthesis is induced to sustain root growth (Angkawijaya et al, 2017).…”

mentioning

confidence: 99%

“…The two latter lipid forms are devoid of Pi, which allows the cell to recycle this element into other pathways that require Pi. Many enzymes involved in this process are well known, and independent pathways are concomitantly triggered to ensure a fast and sizable lipid remobilization (Nakamura, 2013;Pant et al, 2015). For instance, SQD1 and SQD2 are involved in sulfolipid biosynthesis, whereas MGD2 and MGD3 are strongly induced to increase galactolipid content (Yu et al, 2002;Jouhet et al, 2004;Nakamura et al, 2005;Kobayashi et al, 2009).…”

mentioning

confidence: 99%

See 2 more Smart Citations

The Phosphate Fast-Responsive Genes PECP1 and PPsPase1 Affect Phosphocholine and Phosphoethanolamine Content

et al. 2018

View full text Add to dashboard Cite

Phosphate starvation-mediated induction of the HAD-type phosphatases PPsPase1 (AT1G73010) and PECP1 (AT1G17710) has been reported in Arabidopsis (Arabidopsis thaliana). However, little is known about their in vivo function or impact on plant responses to nutrient deficiency. The preferences of PPsPase1 and PECP1 for different substrates have been studied in vitro but require confirmation in planta. Here, we examined the in vivo function of both enzymes using a reverse genetics approach. We demonstrated that PPsPase1 and PECP1 affect plant phosphocholine and phosphoethanolamine content, but not the pyrophosphate-related phenotypes. These observations suggest that the enzymes play a similar role in planta related to the recycling of polar heads from membrane lipids that is triggered during phosphate starvation. Altering the expression of the genes encoding these enzymes had no effect on lipid composition, possibly due to compensation by other lipid recycling pathways triggered during phosphate starvation. Furthermore, our results indicated that PPsPase1 and PECP1 do not influence phosphate homeostasis, since the inactivation of these genes had no effect on phosphate content or on the induction of molecular markers related to phosphate starvation. A combination of transcriptomics and imaging analyses revealed that PPsPase1 and PECP1 display a highly dynamic expression pattern that closely mirrors the phosphate status. This temporal dynamism, combined with the wide range of induction levels, broad expression, and lack of a direct effect on Pi content and regulation, makes PPsPase1 and PECP1 useful molecular markers of the phosphate starvation response.Plant growth is highly sensitive to a lack of phosphate (Pi); hence, the application of Pi fertilizers has become standard practice for high-throughput crop production (Cordell et al., 2009). Most phosphorus in the soil is not available to plants, as it is combined with other minerals or parts of organic compounds (Bieleski, 1973;Raghothama and Karthikeyan, 2005). Only a small fraction of soluble Pi (usually present at a concentration of ,10 mM in the soil) can be taken up by plants.Although growth is not optimal under limiting conditions, plants can withstand changing Pi concentrations within heterogeneous soils or in the external nutrient supply that can lead to reprogramming of their metabolism and architecture (Hammond et al., 2003;Péret et al., 2011;Plaxton and Tran, 2011). Root architecture can be modified to facilitate Pi uptake by favoring the development of lateral roots (at the expense of primary root elongation in many plants including Arabidopsis), increasing the density and length of root hairs, and limiting the development of aerial parts (López-Bucio et al., 2002;Svistoonoff et al., 2007;Gruber et al., 2013). Pi uptake mechanisms are enhanced at the root/soil interface, particularly through the stimulation of Pi transport activity (Mudge et al., 2002;Shin et al., 2004;Nussaume et al., 2011; Ayadi et al., 2015). In parallel, mobilization of Pi sources fr...

show abstract

MYB‐like transcription factor NoPSR1 is crucial for membrane lipid remodeling under phosphate starvation in the oleaginous microalga Nannochloropsis oceanica

et al. 2020

View full text Add to dashboard Cite

Edited by Ulf-Ingo Fl€ ugge Membrane lipid remodeling under phosphate (Pi) limitation, a process that replaces structural membrane phospholipids with nonphosphorus lipids, is a widely observed adaptive response in plants and algae. Here, we identified the transcription factor phosphorus starvation response 1 (NoPSR1) as an indispensable player for regulating membrane lipid conversion during Pi starvation in the microalga Nannochloropsis oceanica. Knocking out NoPSR1 scarcely perturbed membrane lipid composition under Pi-sufficient conditions but significantly impaired dynamic alteration in membrane lipids during Pi starvation. In contrast, the absence of NoPSR1 led to no obvious change in cell proliferation or storage lipid accumulation under either nutrient-sufficient or Pi-deficient conditions. Our results demonstrate a key factor controlling the membrane lipid profile during the Pi starvation response in N. oceanica.

show abstract

Phosphate starvation and membrane lipid remodeling in seed plants

Cited by 167 publications

References 85 publications

Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt

Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt

The Phosphate Fast-Responsive Genes PECP1 and PPsPase1 Affect Phosphocholine and Phosphoethanolamine Content

MYB‐like transcription factor NoPSR1 is crucial for membrane lipid remodeling under phosphate starvation in the oleaginous microalga Nannochloropsis oceanica

Contact Info

Product

Resources

About