Phosphate glass-based microstructured optical fibers with hole and core for biomedical applications

Rizi, Seyed H. Mussavi; Boetti, Nadia Giovanna; Pugliese, Diego; Janner, Davide

doi:10.1016/j.optmat.2022.112644

Cited by 11 publications

(8 citation statements)

References 52 publications

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“…However, the fabrication process of traditional PCF sensors [6][7][8] is relatively complex, which limits their industrial application and development. Compared with traditional PCF sensors, D-shaped photonic crystal fiber sensors [9][10][11] solve the complexity of the fabrication and detection processes.…”

Section: Introductionmentioning

confidence: 99%

Ultra-wide measurement range D-shaped photonic crystal fiber sensor based on surface plasmon resonance

Zhang,

Yang,

Dong

2024

Preprint

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In this paper, a kind of D-type photonic crystal fiber (PCF) sensor with an ultra-wide detection range based on micro-opening gold film coating is proposed. This sensor allows for the sensing detection of the refractive index (RI) of the analyte ranging from 1.30 to 1.42. However, the sensor coated with a micro-opening gold film only achieves an average wavelength sensitivity of 1489 nm/RIU in the x-polarization direction. To improve the performance of the sensor, an attempt was made to replace the micro-opening gold film with MoO2 nanofilm. After simulation calculation, it was found that the RI detection range of the sensor using MoO2 nano-film became 1.33–1.39. Excitingly, the average wavelength sensitivity in the x-polarized direction reaches 17, 178 nm/RIU, which is 11.5 times better than the original sensor. This implies that the sensor is more sensitive to changes in the RI and can provide more accurate sensing and detection results. It has been demonstrated that the performance of a D-type PCF sensor can be significantly improved by using MoO2 nanofilm. This improvement helps to expand the application domain of sensors and enhance the accuracy of sensing detection. We believe that this research result has important implications for the development of fiber sensor technologies.

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Section: Introductionmentioning

confidence: 99%

Ultra-wide measurement range D-shaped photonic crystal fiber sensor based on surface plasmon resonance

Zhang,

Yang,

Dong

2024

Preprint

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“…This is a particular concern in the context of this study given that we are proposing to target the antibacterial properties of Cu-doped phosphate glasses in tissue engineering and regenerative medicine. However, as reported above, phosphate glasses can be transparent and be drawn as a fiber optics guiding light, allowing to realize implantable devices for diagnostics and photodynamic therapy. , This fact can represent a major advance for bioresorbable and implantable fiber optic devices for personalized medicine. The objective of the present study is to synthesize and characterize low-concentration copper-doped glasses (CPGs_Cu) with 1 mol % CuO and undoped glasses (CPGs), starting from a calcium phosphate formulation that is transparent and drawable in fiber forms.…”

Section: Introductionmentioning

confidence: 99%

Effect of Low Copper Doping on the Optical, Cytocompatible, Antibacterial, and SARS-CoV-2 Trapping Properties of Calcium Phosphate Glasses

Restivo,

Pugliese,

Gallichi-Nottiani

et al. 2023

ACS Omega

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Calcium phosphate glasses (CPGs) are acquiring great importance in the biomedical field because of their thermomechanical and bioresorbable properties. In this study, optically transparent copper (1 mol %)-doped calcium phosphate glasses (CPGs_Cu) were prepared through the melt-quenching method, and their biocompatibility and antibacterial and antiviral properties were evaluated and compared with undoped CPGs. Biocompatibility was evaluated on murine fibroblast NIH-3T3 cells as a preliminary study of cytocompatibility. The in vitro tests were performed through indirect and direct cytotoxicity analyses by MTT and Alamar Blue assays and supported by electron microscopy observations. Microbiological analyses were performed against the most common Gram-negative and Gram-positive pathogens that cause nosocomial infections: Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, and the methicillin-resistant Staphylococcus aureus strain. In addition, the bioglass samples were exposed to SARS-CoV-2 to assess their effects on viral survival. The obtained results assessed the biocompatibility of both bioglass types and their ability to reduce the viral load and trap the virus. In addition, Cu2+-doped bioglass was found to be antibacterial despite its low content (1 mol %) of copper, making this a promising candidate material for biomedical applications, e.g., surgery probes, drug delivery, and photodynamic therapy.

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“…13 Among the reported achievements Gallichi-Nottiani et al 14 prepared a microstructured bioresorbable fiber by first extruding phosphate glass capillaries and then fusing the capillaries together during drawing, demonstrating the use of bioresorbable glass in microstructured fibers. Rizi et al 15 demonstrated the combined guiding of a laser beam in a core-clad fiber and of a fluid in a capillary, both guides being made from bioresorbable materials stacked in a single circular fiber.…”

Section: Introductionmentioning

confidence: 99%

Characterization of biodegradable core–clad borosilicate glass fibers with round and rectangular cross‐section

Hongisto,

Ghanavati,

Lemiere

et al. 2023

J Am Ceram Soc.

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Here, we report on core–clad bioactive borosilicate fibers, that we have prepared both with round and rectangular cross‐section profile. The exposed approach, which relies on the stacking and drawing of glass slabs, demonstrates our ability to develop bioactive‐based glass fibers with tailored cross‐section profiles. Tens‐of‐meters‐long fibers were successfully drawn, although suffering from elevated losses in the case of the rectangular ones. The response of the fibers in simulated body fluid was studied for both geometries. We found that a round cladding can act as protective layer, tempering effects of the corrosion. We also noticed that rectangular fibers are more prone to degradation, the enhanced corrosion beginning from their sharp corners as they accumulated residual tensile stress during drawing. To the best of our knowledge, this is the first report on the effect of residual tensile stresses from surface tension deformations applied to the corrosion of rectangular fibers. As geometry plays a critical role on the biodegradation behavior of the fiberglass, we believe the enclosed results could lead to the design of fiber devices with tailored cross‐section profile in order to tune their rate of degradation on solely based geometrical effects.

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Phosphate glass-based microstructured optical fibers with hole and core for biomedical applications

Cited by 11 publications

References 52 publications

Ultra-wide measurement range D-shaped photonic crystal fiber sensor based on surface plasmon resonance

Ultra-wide measurement range D-shaped photonic crystal fiber sensor based on surface plasmon resonance

Effect of Low Copper Doping on the Optical, Cytocompatible, Antibacterial, and SARS-CoV-2 Trapping Properties of Calcium Phosphate Glasses

Characterization of biodegradable core–clad borosilicate glass fibers with round and rectangular cross‐section

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