Phosphate concentration in ophthalmic corticoid preparations

Bernauer, Wolfgang; Thiel, Michael; Rentsch, Katharina

doi:10.1007/s00417-008-0788-5

Cited by 8 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2006), fluorometholone (phosphorus content <0.1–22.5 mmol/l) and dexamethasone (phosphorus content 0.1–17.6 mmol/l) (Bernauer et al. 2008). Therefore, eyedrops with physiologic phosphate concentrations are recommended for patients with corneal defects.…”

Section: Discussionmentioning

confidence: 99%

“…The use of phosphate-containing eyedrops may increase the concentration of phosphate and promote the development of calcification (Taravella et al 1994;Anderson et al 2003;Bernauer et al 2006;Schrage et al 2010). In this study, three types of phosphate-containing eyedrops were commonly used for all patients after LKP: 0.3% sodium hyaluronate (Biolan, Santen, phosphorus content 2.1 mmol/l) (Bernauer et al 2006), fluorometholone (phosphorus content <0.1-22.5 mmol/l) and dexamethasone (phosphorus content 0.1-17.6 mmol/l) (Bernauer et al 2008). Therefore, eyedrops with physiologic phosphate concentrations are recommended for patients with corneal defects.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Corneal calcification of acellular porcine corneal stroma following lamellar keratoplasty

Dong

Zhou

et al. 2020

Acta Ophthalmologica

View full text Add to dashboard Cite

Purpose: To describe the corneal calcification of acellular porcine corneal stroma (APCS) following lamellar keratoplasty (LKP) and identify risk factors. Methods: Two cases of APCS calcification were evaluated by slit-lamp photography and anterior segment optical coherence tomography (AS-OCT). von Kossa staining and scanning electron microscope/energy-dispersive spectrometry (SEM/EDS) were performed on pathologic tissue. Associated graft and postoperative risk factors were analysed. Acellular porcine corneal stroma (APCS) cleanliness and element content after rinsing with sterilized water were observed by SEM/EDS and inductively coupled plasma mass spectrometry. Calcium metabolism-related proteins were analysed by protein mass spectrometry. Corneal epithelial defects and postoperative medications were reviewed. Results: Two cases of APCS calcification occurred at 23 and 22 days postoperatively. Anterior segment optical coherence tomography (AS-OCT) and von Kossa staining demonstrated calcium deposition in the superficial stroma composed of calcium, phosphorus and oxygen conforming to the Ca/P ratio of hydroxyapatite. Phosphate crystals were present on the APCS surface and decreased with number of rinsing times. The phosphorus content of APCS was minimal after rinsing 10 times and avoiding excessive corneal swelling. Calcium metabolism-related proteins were downregulated in APCS. Patients with corneal calcification had 1-week postoperative corneal epithelial defects and were treated with three types of phosphorous eyedrops. Conclusions: Acellular porcine corneal stroma (APCS) calcification occurs in the superficial corneal stroma about 1 month after LKP. The application of AS-OCT, von Kossa staining and SEM/EDS provides a basis for the clinical and pathological diagnosis of corneal calcification. The associated risk factors were mainly high phosphorus content and downregulated calcium metabolism-related proteins in APCS. Postoperative epithelial defects, inflammation and use of phosphorous eyedrops may promote corneal calcification.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Corneal calcification of acellular porcine corneal stroma following lamellar keratoplasty

Dong

Zhou

et al. 2020

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…1 Phosphate, a commonly used buffer, is a vehicle with high buffering capacity that stabilizes the pH level at 7.4, and can also be found in some formulations as part of the active ingredient. 1,3,4 In addition, it has the added advantage of making corticosteroid-containing solutions more transparent. 3…”

Section: Introductionmentioning

confidence: 99%

Assessment of Phosphate and Osmolarity Levels in Chronically Administered Eye Drops

Özalp

Atalay

Kebapçı

et al. 2019

tjo

View full text Add to dashboard Cite

Objectives: To assess phosphate and osmolarity levels of chronically administered eye drops commercially available in Turkey. Materials and Methods: A total of 53 topical eye drops including 18 antiglaucoma drugs, 4 nonsteroidal anti-inflammatory drugs (NSAIDs), 10 corticosteroids, 7 antihistaminics, and 14 artificial tears identified using the Vademecum Modern Medications Guideline (2018) were included in the study. Phosphate levels were assessed using Roche Cobas C501 analyzer (Roche Diagnostics GmbH, Mannheim, Germany) and the respective kits. Osmolarity was assessed using Vescor Vapro 5600 vapor pressure osmometer (Sanova Medical Systems, Vienna, Austria). Mean phosphate and osmolarity levels were obtained after averaging three measurements. Eye drops were categorized as isoosmolar, hypoosmolar and hyperosmolar based on physiologic tear osmolarity range (296.5±9.8 mOsm/L). Results: The highest phosphate concentration was found in the antiglaucoma group (20.3±35.4 mmol/L), followed by antihistaminics (17.3±17.9 mmol/L), corticosteroids (15.2±19.1 mmol/L), artificial tears (0.8±1.0), and NSAIDs (0.04±0.08). Percentage of medications in the hyperosmolar category was highest in the NSAI group (75%), followed by antihistaminics (43%), corticosteroids (20%), and antiglaucoma drugs (19%). Nearly all of the artificial tear formulations were in the hypoosmolar (71%) or isoosmolar (21%) categories. Conclusion: Approximately 40% of glaucoma medications and approximately 60% of corticosteroid and antihistaminic medications had a phosphate concentration higher than the physiologic tear phosphate level (1.45 mmol/L).

show abstract

Augenirritation und Augenverätzungen

Schrage¹

2016

Verbrennungschirurgie

View full text Add to dashboard Cite

Phosphate concentration in ophthalmic corticoid preparations

Cited by 8 publications

References 9 publications

Corneal calcification of acellular porcine corneal stroma following lamellar keratoplasty

Corneal calcification of acellular porcine corneal stroma following lamellar keratoplasty

Assessment of Phosphate and Osmolarity Levels in Chronically Administered Eye Drops

Augenirritation und Augenverätzungen

Contact Info

Product

Resources

About