Phosphate Compounds in Vertebrate Red Blood Cells

Bartlett, Grant R.

doi:10.1093/icb/20.1.103

Cited by 90 publications

(16 citation statements)

References 9 publications

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“…Binding sites for these allosteric effectors are mainly located at the N-and C-termini of the globin subunits and in the positively charged central cavity of the Hb tetramer (Arnone, 1972;Arnone and Perutz, 1974;O'Donnell et al, 1979;Nigen et al, 1980). Different organic phosphates serve as allosteric effectors in the definitive red blood cells of different groups of terrestrial vertebrates: 2,3-diphosphoglycerate (2,3-DPG) in mammals, inositol pentaphosphate (IPP) in birds, adenosine triphosphate (ATP) and guanosine triphosphate (GTP) in non-avian reptiles, and ATP and DPG in amphibians (Rapoport and Guest, 1941;Benesch and Benesch, 1967;Bartlett, 1980;Hazard and Hutchison, 1982;Weber, 1995;Weber and Fago, 2004). These polyphosphate molecules electrostatically bind to a constellation of cationic residues lining the cleft between the β-chains of deoxyHb, thereby stabilizing the T-state through the formation of salt bridges within and between the α-and β-chain subunits (Arnone, 1972;Arnone and Perutz, 1974).…”

Section: Heterotropic Allosterymentioning

confidence: 99%

Hemoglobin–oxygen affinity in high-altitude vertebrates: is there evidence for an adaptive trend?

Storz

2016

Journal of Experimental Biology

112

100

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In air-breathing vertebrates at high altitude, fine-tuned adjustments in hemoglobin (Hb)-O 2 affinity provide an energetically efficient means of mitigating the effects of arterial hypoxemia. However, it is not always clear whether an increased or decreased Hb-O 2 affinity should be expected to improve tissue O 2 delivery under different degrees of hypoxia, due to the inherent trade-off between arterial O 2 loading and peripheral O 2 unloading. Theoretical results indicate that the optimal Hb-O 2 affinity varies as a non-linear function of environmental O 2 availability, and the threshold elevation at which an increased Hb-O 2 affinity becomes advantageous depends on the magnitude of diffusion limitation (the extent to which O 2 equilibration at the blood-gas interface is limited by the kinetics of O 2 exchange). This body of theory provides a framework for interpreting the possible adaptive significance of evolved changes in Hb-O 2 affinity in vertebrates that have colonized high-altitude environments. To evaluate the evidence for an empirical generalization and to test theoretical predictions, I synthesized comparative data in a phylogenetic framework to assess the strength of the relationship between Hb-O 2 affinity and native elevation in mammals and birds. Evidence for a general trend in mammals is equivocal, but there is a remarkably strong positive relationship between Hb-O 2 affinity and native elevation in birds. Evolved changes in Hb function in highaltitude birds provide one of the most compelling examples of convergent biochemical adaptation in vertebrates.

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Section: Heterotropic Allosterymentioning

confidence: 99%

Hemoglobin–oxygen affinity in high-altitude vertebrates: is there evidence for an adaptive trend?

Storz

2016

Journal of Experimental Biology

112

100

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“…Of these four organic phos phates detected, Fe-GTP showed higher concentration in all five collect ing trips. Despite the high and variable amounts of Fe-GTP reported in the red blood cells of some fish species, the physiological role of this compound is still not known (Bartlett, 1980;Monteiro etal, 1987;Val etal, 1990).…”

Section: Seasonal Studiesmentioning

confidence: 99%

Respiratory characteristics of Hoplostenum littorale (Siluriformes, Callichthyidae)

Affonso

2001

Acta Amaz.

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-Hematological parameters, intraerythrocytic phosphates, hemoglobin, and whole blood Bohr effect of the South American armored catfish Hoplostenum littorale were studied during different seasons of the year. In addition, the degree of dependence on air breathing was determined for this species. The hematological parameters presented seasonal variations, which were not correlated to oxygen, temperature, and water level oscillations. Five anodic being detected, 2,3-DPG was also detected in red blood cells of H. littorale. The latter is an intraerythrocytic phosphate characteristic to red blood cells of mammalians. The increased be related to environmental temperature increase. Whole blood Bohr effect was influenced by water temperature. This study confirms H. littorale to be continuous and not obligate air breather, under all dissolved oxygen level conditions. Key-words: Adaptation, air-breathing behavior, hematology, intraerythrocytic phosphate, blood Bohr effect. Características Respiratórias de Hoplostenum littorale (Siluriformes, Callichthyidae).RESUMO -Os parâmetros hematológicos, os fosfatos intraeritrocitários, a hemoglobina e o efeito Bohr do sangue de Hoplostenum littorale foram estudados em diferentes períodos do ano. Além disso, foi determinado o grau de dependência da respiração aérea nesta espécie. Os parâmetros hematológicos apresentaram variações sazonais, as quais não foram relacionadas com as variações no oxigênio dissolvido, temperatura e nível de água. Além de ATP, GTP e Fe-GTP terem sido detectados nos eritrócitos de H. littorale, 2,3-DPG também foi detectado. Este último é um fosfato intraeritrocitário característico de células vermelhas de mamíferos. O efeito deste composto sobre a afinidade da Hb-O 2 pode estar relacionado com o aumento da temperatura. O efeito Bohr do sangue foi influenciado pela temperatura da água. Este estudo confirma que H. littorale é um respirador aéreo facultativo que utiliza a respiração aérea mesmo em condições normóxicas.Palavras-chave: Adaptação, comportamento da respiração aérea, hematologia, fosfatos intraeritrocitários, efeito Bohr do sangue.Instituto Nacional de Pesquisas da Amazônia, Coordenação de Pesquisas em Aquicultura, Av.

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“…In adult birds, inositol pentaphosphate (IPP) is the main allosteric effectors in the red cell, instead of BPG, which is found in human Hb (Zhang et al 1996). However, bird embryos also present 2,3-BPG, which disappears at the moment of hatching (Isaacks et al 1976a;Isaacks et al 1976b;Isaacks et al 1976c;Bartlett 1980a;Bartlett 1980b;Borgese Lampert 1975;Isaacks Harckness 1975). Since migration of skuas is a tremendous resistance test, an alteration of Hb functional properties due to different intraerythrocytic organic phosphates content in samples collected at different seasons (after migration and after a period of rest) could be expected.…”

Section: Introductionmentioning

confidence: 99%

Intraerythrocytic organic phosphates and hemoglobins of skua - Catharacta maccormicki (Stercoraridae): at two different stages of the year in relation to Antartic migration

Landini

Neto

Schwantes

et al. 2013

Braz. arch. biol. technol.

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Phosphate Compounds in Vertebrate Red Blood Cells

Cited by 90 publications

References 9 publications

Hemoglobin–oxygen affinity in high-altitude vertebrates: is there evidence for an adaptive trend?

Hemoglobin–oxygen affinity in high-altitude vertebrates: is there evidence for an adaptive trend?

Respiratory characteristics of Hoplostenum littorale (Siluriformes, Callichthyidae)

Intraerythrocytic organic phosphates and hemoglobins of skua - Catharacta maccormicki (Stercoraridae): at two different stages of the year in relation to Antartic migration

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