Phosphatase Alkaline Inhibition and Antithyroid Activity of Acetylacetone Sulfonamide Derived Schiff Base. In Vitro and In Silico Studies
Gisela M. Gaddi,
Janetsi Y. Caro‐Ramírez,
Yamila B. Antonena
et al.
Abstract:The sulfonamide‐derived compounds have demonstrated various pharmaceutical properties. However, the exploration of certain properties, such as phosphatase inhibition and anti‐thyroid activities, has been limited in the existing literature. The present study aimed to investigate these specific activities for the Schiff base (Z)‐4‐(4‐oxopent‐2‐en‐2‐ylamino)benzenesulfonamide. The compound underwent thorough physicochemical characterization, including FTIR, Raman, and UV‐Vis spectroscopy, along with theoretical D… Show more
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