Phosphaplatin Anti-tumor Effect Enhanced by Liposomes Partly via an Up-regulation of PEDF in Breast Cancer

Belkacemi, Louiza; Atkins, Jason L; Lu, Yang; Gadgil, Prajakta; Sater, Amy K.; Chow, Diana; Bose, Rathindra N.; Zhang, Xiaoliu

doi:10.21873/anticanres.12267

Cited by 3 publications

(1 citation statement)

References 43 publications

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“…Many publications highlight that the biological functions of PEDF are diverse and multidimensional [58,64,65]. Some assays link the PEDF molecule to mechanisms that suppress breast cancer metastasis by regulating the epithelial-mesenchymal transition [66][67][68][69]; others report surprising observations, such as that PEDF constitutively activates p42/44 MAPK/Erk but paradoxically does not affect mitogenic signaling [70]. The angiogenic potential of PEDF as an antineoplastic therapy is particularly noteworthy [18,[71][72][73][74].…”

Section: Introductionmentioning

confidence: 99%

Self-Renewal Inhibition in Breast Cancer Stem Cells: Moonlight Role of PEDF in Breast Cancer

Gil-Gas,

Sánchez-Díez,

Honrubia-Gómez

et al. 2023

Cancers

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Breast cancer is the leading cause of death among females in developed countries. Although the implementation of screening tests and the development of new therapies have increased the probability of remission, relapse rates remain high. Numerous studies have indicated the connection between cancer-initiating cells and slow cellular cycle cells, identified by their capacity to retain long labeling (LT+). In this study, we perform new assays showing how stem cell self-renewal modulating proteins, such as PEDF, can modify the properties, percentage of biomarker-expressing cells, and carcinogenicity of cancer stem cells. The PEDF signaling pathway could be a useful tool for controlling cancer stem cells’ self-renewal and therefore control patient relapse, as PEDF enhances resistance in breast cancer patient cells’ in vitro culture. We have designed a peptide consisting of the C-terminal part of this protein, which acts by blocking endogenous PEDF in cell culture assays. We demonstrate that it is possible to interfere with the self-renewal capacity of cancer stem cells, induce anoikis in vivo, and reduce resistance against docetaxel treatment in cancer patient cells in in vitro culture. We have also demonstrated that this modified PEDF protein produces a significant decrease in the percentage of expressed cancer stem cell markers.

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Section: Introductionmentioning

confidence: 99%

Self-Renewal Inhibition in Breast Cancer Stem Cells: Moonlight Role of PEDF in Breast Cancer

Gil-Gas,

Sánchez-Díez,

Honrubia-Gómez

et al. 2023

Cancers

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Lipid droplet velocity is a microenvironmental sensor of aggressive tumors regulated by V-ATPase and PEDF

Nardi

Fitchev

Brooks

et al. 2019

Laboratory Investigation

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A facile one-pot expeditious synthesis of triazolothiadiazines and anticancer activity

Arandkar

Vedula

2018

Phosphorus, Sulfur, and Silicon and the Related Elements

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Phosphaplatin Anti-tumor Effect Enhanced by Liposomes Partly via an Up-regulation of PEDF in Breast Cancer

Abstract: Free RRD4 or formulated into liposomes, are excellent candidates for adjuvant therapy against breast tumor growth and metastasis.

Cited by 3 publications

References 43 publications

Self-Renewal Inhibition in Breast Cancer Stem Cells: Moonlight Role of PEDF in Breast Cancer

Self-Renewal Inhibition in Breast Cancer Stem Cells: Moonlight Role of PEDF in Breast Cancer

Lipid droplet velocity is a microenvironmental sensor of aggressive tumors regulated by V-ATPase and PEDF

A facile one-pot expeditious synthesis of triazolothiadiazines and anticancer activity

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