Phosphanilic acid inhibits dihydropteroate synthase

Eagon, R. G.; McManus, Albert T.

doi:10.1128/aac.33.11.1936

Cited by 17 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…p-Aminobenzoic acid has been found to inhibit P . aeruginosa and E. coli (Eagon & McManus 1989 and to affect the cell permeability of P . aeruginosa causing an increased uptake and thus an increased activity of dibromopropamidine isethionate present in the medium (Richards & Xing 1992a).…”

Section: Discussionmentioning

confidence: 99%

Investigation of Synergism between Combinations of Ciprofloxacin, Polymyxin, Sulphadiazine and p-Aminobenzoic acid

Richards

Xing

1993

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Subinhibitory concentrations of combinations of any two of ciprofloxacin, colistin (or polymyxin B), sodium sulphadiazine and p-aminobenzoic acid were shown by checkerboard minimum inhibitory concentration determinations to have synergistic inhibitory activity against Pseudomonas aeruginosa and to have either synergistic or additive activity against Staphylococcus aureus. In addition, sulphadiazine plus either ciprofloxacin or polymyxin showed markedly enhanced killing activity against both P. aeruginosa and S. aureus. p-Aminobenzoic acid plus either ciprofloxacin or polymyxin also demonstrated enhanced killing activity against P. aeruginosa but these combinations were less effective in enhancing activity against S. aureus. Ciprofloxacin in combination with polymyxin had a marked synergistic effect against P. aeruginosa but only a slight synergistic effect against S. aureus. These findings indicate a potential usefulness for the synergistic combinations against P. aeruginosa and S. aureus in the clinical situation; that is, they indicate an extended role for sulphonamides and support a potential role for p-aminobenzoic acid as enhancers of the activity of primary antibacterial agents such as ciprofloxacin and polymyxin. We suggest that for a second antibacterial to enhance the activity of ciprofloxacin, it may be necessary for the second antibacterial to increase cell permeability so increasing bacterial uptake of ciprofloxacin.

show abstract

Section: Discussionmentioning

confidence: 99%

Investigation of Synergism between Combinations of Ciprofloxacin, Polymyxin, Sulphadiazine and p-Aminobenzoic acid

Richards

Xing

1993

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…Sulfonamide is an antagonist for para‐aminobenzoic acid (PABA), a component of folic acid. To block the folate‐inhibiting activity [8] of SDZ, 15 μg ml −1 (ca. 109 μM) of PABA was added to media containing 25 μg ml −1 (ca.…”

Section: Resultsmentioning

confidence: 99%

Enhanced anti-Shigellaactivity of erythromycin supplemented with sulfadiazine

Honma

Sasakawa

Tsuji

et al. 2001

FEMS Immunology &Amp; Medical Microbiology

View full text Add to dashboard Cite

Sulfadiazine enhanced the anti-Shigella activity of erythromycin. Erythromycin passes through the type III secretion apparatus and suppresses the growth of invasive Shigella organisms. Sulfadiazine enhanced this effect at the concentration under minimum inhibitory concentration and it came from not only the folate-inhibiting activity but also from a new function. It has proved that sulfadiazine stimulated type III secretion in Shigella as determined from the secretion of the pathogenic protein IpaB. As Congo red induced secretion of Ipa proteins and uptake of erythromycin through the type III secretion gate, sulfadiazine which is similar to Congo red in chemical structure may induce the uptake in the same way. ß

show abstract

“…Sulfonamide is an antagonist for para-aminobenzoic acid (PABA), a component of folic acid. To block the folate-inhibiting activity [8] of SDZ, 15 Wg ml 31 (ca. 109 WM) of PABA was added to media containing 25 Wg ml 31 (ca.…”

Section: Resultsmentioning

confidence: 99%