“…This idea was subsequently challenged by several reports indicating that most phosducin in the rod cell is located outside the outer segment, a photoreceptor's organelle where the visual signal transduction takes place (Lee et al, 1988;Gropp et al, 1997;Thulin et al, 1999;Nakano et al, 2001;Sokolov et al, 2004). Yet no direct evidence supporting or rejecting this putative mechanism has been reported so far and the hypothesis is still commonly discussed (e.g., Klenk et al, 2006;Partridge et al, 2006). On the other hand, phosducin was demonstrated to participate in another cellular function by assisting transducin βγ subunits in their light-driven translocation from rod outer segments (Sokolov et al, 2004), a process that takes place after prolonged exposure of rods to very bright light bleaching at least 4,000-6,000 rhodopsin molecules per rod per second (Sokolov et al, 2002;Lobanova et al, 2007;see Calvert et al, 2006 for a recent review).…”