Phorbolesters — the Irritants and Cocarcinogens of Croton Tiglium L.

Hecker, Erich; Schmidt, Rainer

doi:10.1007/978-3-7091-7094-6_7

Cited by 122 publications

(133 citation statements)

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“…[1][2][3][4]. These compounds are, in addition, the most potent class of tumor promoters for mouse skin (5,6). This laboratory and others (7)(8)(9)(10)(11)(12)(13) have demonstrated high-affinity specific receptors for phorbol esters in membrane preparations and in intact cells with [3H]phorbol 12,13-dibutyrate (PBt2).…”

mentioning

confidence: 99%

Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol.

Leach¹,

James²,

Blumberg³

1983

Proc. Natl. Acad. Sci. U.S.A.

244

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mentioning

confidence: 99%

Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol.

Leach¹,

James²,

Blumberg³

1983

Proc. Natl. Acad. Sci. U.S.A.

244

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“…However, a number of Croton species are known to present carcinogenic and irritating effects due to the presence of phorbol diterpene esters among their chemical constituents (Hecker & Schmidt 1974;Weber & Hecker 1978). In previous studies (Maciel et al 1998), our group found no harmful compounds in Croton cajucara, which may explain the apparent absence of toxic effects in derivatives of this plant when used in moderation.…”

Section: Discussionmentioning

confidence: 55%

Mutagenicity and antimutagenicity of Croton cajucara

Santos

Farias

et al. 2008

Biologia

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Croton cajucara Benth. ('sacaca') is a tree of the Euphorbiaceae family, native to the Amazon region in northern Brazil, where it is widely used in the popular treatment of various diseases. Its active principle, the terpenoid transdehydrocrotonin, has been credited with a variety of medical properties, including antiulcer, antiinflammatory, antitumor, antimutagenic and hypoglycemic activity. In this investigation, possible mutagenic and antimutagenic effects were evaluated in treatments using methanol extract of this plant on Swiss Albino mice by examining their peripheral blood cells for micronuclei. In these tests, the material obtained by methanol extraction of C. cajucara tree bark was administered to the mice by gavage. None of the doses evaluated in this study presented mutagenicity. Analysis of the results obtained from studies evaluating antimutagenicity revealed protection against the chemotherapeutic agent cyclophosphamide for the two highest doses used.

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“…Our results agree with those of Agner et al (1999) who subjected mice to acute treatment with DCTN (the major ingredient of C. cajucara) and found no significant genotoxic activity for this compound. In our experiments, the absence of genotoxicity may have been due to the absence of forbol diterpene esters which are present in many toxic Croton species and are known to cause various toxic effects and to be carcinogenic (Hecker and Schmidt, 1974;Weber and Hecker, 1978).…”

Section: Discussionmentioning

confidence: 62%

Absence of mutagenicity in somatic and germ cells of mice submitted to subchronic treatment with an extract of Croton cajucara Benth. (Euphorbiaceae)

et al. 2006

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The plant Croton cajucara Benth. (Euphorbiaceae) is a medicinal plant from the Brazilian Amazon where it is commonly known as sacaca. The principal compound isolated from C. cajucara stem-bark extracts is the clerodane-type diterpene trans-dehydrocrotonin (DCTN) which presents several biological activities, including antiulcerogenic, anti-inflammatory, hypoglycemic, antimutagenic and antitumoral activity. However, few studies have been carried out to evaluate the therapeutic potential of raw C. cajucara extracts. We studied mutagenicity and antimutagenicity effects of C. cajucara methanol extract using the micronucleus assay in bone marrow cells and the dominant lethal assay in mice submitted to subchronic treatments. The blood testosterone levels of the mice were also measured to assess the effects of the methanol extract on testes function. Statistical analysis of the data obtained in this study showed no statistically significant mutagenicity attributable to C. cajucara stem-bark extracts, nor did such extracts show antimutagenic activity at the concentrations assessed. The testosterone concentration was normal in all the mice studied.

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Phorbolesters — the Irritants and Cocarcinogens of Croton Tiglium L.

Cited by 122 publications

References 126 publications

Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol.

Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol.

Mutagenicity and antimutagenicity of Croton cajucara

Absence of mutagenicity in somatic and germ cells of mice submitted to subchronic treatment with an extract of Croton cajucara Benth. (Euphorbiaceae)

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