Phorbol myristate acetate-induced modulation of antibody-dependent cellular cytotoxicity by human polymorphonuclear leukocytes

Ichinose, Yukito; Yagawa, Katsuro; Kaku, Mariko; Hara, Nobuyuki; Ohta, Mitsuo

doi:10.1128/iai.46.3.682-685.1984

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…Many of the reports listed in Tables I and II discuss the anticancer effect of PMN via ADCC,27, 41, 46, 50, 64, 83, 116, 120, 122–126, 128, 129, 131–177 and many provide direct evidence of this antibody‐mediated antitumoral role of PMN in vitro. The first reports were published in 1974 and 1975 by Gale and Zighelboim 131, 132.…”

Section: Antibody‐dependent Tumor Killingmentioning

confidence: 99%

Polymorphonuclear neutrophils and cancer: Intense and sustained neutrophilia as a treatment against solid tumors

Souto

Vilá

Brú

2011

Medicinal Research Reviews

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Polymorphonuclear neutrophils (PMN) are the most abundant circulating immune cells and represent the first line of immune defense against infection. This review of the biomedical literature of the last 40 years shows that they also have a powerful antitumoral effect under certain circumstances. Typically, the microenvironment surrounding a solid tumor possesses many of the characteristics of chronic inflammation, a condition considered very favorable for tumor growth and spread. However, there are many circumstances that shift the chronic inflammatory state toward an acute inflammatory response around a tumor. This shift seems to convert PMN into very efficient anticancer effector cells. Clinical reports of unexpected antitumoral effects linked to the prolonged use of granulocyte colony-stimulating factor, which stimulates an intense and sustained neutrophilia, suggest that an easy way to fight solid tumors would be to encourage the development of intense peritumoral PMN infiltrates. Specifically designed clinical trials are urgently needed to evaluate the safety and efficacy of such drug-induced neutrophilia in patients with solid tumors. This antitumoral role of neutrophils may provide new avenues for the clinical treatment of cancer.

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Section: Antibody‐dependent Tumor Killingmentioning

confidence: 99%

Polymorphonuclear neutrophils and cancer: Intense and sustained neutrophilia as a treatment against solid tumors

Souto

Vilá

Brú

2011

Medicinal Research Reviews

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“…Effect of pretreatment with low concentrations of PMA on 02 generation in the absence of extracellular Ca2 . PMA is known not only to be a potent biological stimulator but also to have a potentiating effect on cellular function (9,19). To examine whether Ca2+-dependent O,-generation by stimulation with YI 51 is modulated by pretreatment with low concentrations of PMA, the amount of 02-generation induced by YI 51-bound PMN preincubated with the reagent over a concentration range of 1010 to 10-9 M in Ca2+-free medium for 10 min was measured after addition of F(ab')2 fragments of rabbit anti-mouse immunoglobulin antibody.…”

Section: Resultsmentioning

confidence: 99%

“…We did, however, determine that YI 51 appears to bind to a molecule other than Fc,rR or to an epitope on Fc,rR that is distinct from the Fc-binding site because of the following findings. (i) YI 51 could not bind to cells of HL 60 and K 562 which had been reported to have Fc,R ( PMA is known not only to be a potent biological stimuilus but also to have a potentiating effect on cell function (9,19). We thus investigated whether pretreatment of PMN with low concentrations of PMA was able to modulate O-generation by the cells subsequent to stimulation.…”

Section: Resultsmentioning

confidence: 99%

Phorbol myristate acetate modulates calcium ion-dependent superoxide anion generation induced by a monoclonal antibody raised against polymorphonuclear leukocytes

et al. 1989

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We used a monoclonal antibody, YI 51, raised against human polymorphonuclear leukocytes (PMN) to induce superoxide anion (02-) generation in cells. Although YI 51 alone played only a small part in inducing 0-generation in PMN, the amount of 02-generation induced in 5 x 105 PMN was 3.7 to 5.5 nmol/min when F(ab')2 fragments of rabbit anti-mouse immunoglobulin antibody were added as a cross-linking agent. This 0--inducing activity was high compared with that of wheat germ agglutinin (WGA), insoluble immunoglobulin G immune complexes (IC), or phorbol myristate acetate (PMA). The binding of YI 51 and soluble immunoglobulin G IC to PMN was not reciprocally inhibitory, indicating that YI 51 does not interfere with ligand binding to the Fc receptor-binding site. In the absence of calcium ion (Ca2+), 0-generation induced by YI 51 decreased to 10 to 20% of that in the presence of Ca2 . In contrast, 02 generation in response to WGA, IC, or PMA under Ca2+-free conditions was not affected. When PMN were pretreated with low concentrations of PMA (10-10 to 10-9 M), the amount of 02-generation by the cells in response to YI 51 in Ca2+-free buffer was enhanced in a concentration-dependent manner. It also equaled the 2-generated by the cells in buffer containing Ca2+. In cells pretreated with PMA, the amount of 02 induced by WGA was enhanced two-to threefold over that in untreated cells. In contrast, there was no augmentation over untreated cells with stimulation by IC. These results suggest that YI 51, IC, and WGA induce 2-generation in human PMN in different manners.

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Influence of chemotherapy on superoxide anion-generating activity of polymorphonuclear leukocytes in patients with lung cancer

Ichinose

Hara

Motohiro

et al. 1986

Cancer

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The superoxide anion (O2-) generating activity of polymorphonuclear leukocytes (PMN) in peripheral venous blood obtained from 15 patients with lung cancer was measured weekly after drug treatment. The amount of O2- generated by the cells before chemotherapy was 5.74 +/- 0.42 nmol/minute/10(6) cells (mean +/- SE). The value decreased gradually and reached a nadir of 1.98 +/- 0.24 at 2 weeks after chemotherapy, at which time PMN count also reached a nadir of 1359 +/- 251/microliters (mean +/- SE). The decreased O2- generating activity of the PMN recovered gradually thereafter and reached the level seen before the chemotherapy at 4 weeks. Expression of Fc receptors on the plasma membrane in PMN was measured after chemotherapy by the binding of iodine 125 (125I)-immune complexes to the cells. Almost 40% decrease of the binding was observed in the cells obtained at 2 weeks after chemotherapy, compared with that in the cells before chemotherapy. These results indicate that PMN present in peripheral blood at 2 weeks after chemotherapy are not fully matured, in terms of O2- generating activity and the expression of Fc receptors.

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Phorbol myristate acetate-induced modulation of antibody-dependent cellular cytotoxicity by human polymorphonuclear leukocytes

Cited by 5 publications

References 16 publications

Polymorphonuclear neutrophils and cancer: Intense and sustained neutrophilia as a treatment against solid tumors

Polymorphonuclear neutrophils and cancer: Intense and sustained neutrophilia as a treatment against solid tumors

Phorbol myristate acetate modulates calcium ion-dependent superoxide anion generation induced by a monoclonal antibody raised against polymorphonuclear leukocytes

Influence of chemotherapy on superoxide anion-generating activity of polymorphonuclear leukocytes in patients with lung cancer

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