Phomopsischalins A–C, polycyclic-fused cytochalasins from the endophytic fungus Phomopsis sp. shj2 and their abilities to induce lysosomal function

Abstract

Phomopsischalins A (1) and B (2), two unprecedented cytochalasins featuring a 5/6/6/7-fused tetracyclic ring system, and Phomopsischalin C (3) bearing a 5/6/5/8-fused tetracyclic ring system, were isolated from the endophytic...

Cactus Endophytic Fungi and Bioprospecting for their Enzymes and Bioactive Molecules: A Systematic Review

“…The genus Diaporthe / Phomopsis showed the potential to produce several cytochalasins [7,12,63] . The cytochalasins are fungal toxins with cell membrane permeability that exhibit structural diversity and several biological effects, such as cytotoxic, anticancer, antimicrobial and antiparasitic activities, inhibition of acetylcholinesterase enzyme in vitro and promotion of lysosomal function [12,64–68] …”

Isatin-based spiro indolenine alkaloids from Isatis indigotica Fortune with anti-neuroinflammatory and acetylcholinesterase inhibitory effects

“…Conformational analysis of the isolated compounds was carried out with the MMFF94 force field in CONFLEX software. 33,34 All obtained conformers were screened based on the energy of optimized structures at the B3LYP/6-31G(d) level with an energy window of 10 kcal mol −1 using the Gaussian 09 program package. 35 The theoretical ECD calculations of the conformations of compounds were performed with the TDDFT method at the B3LYP/6-311++G(2d,p) level with the CPCM model in methanol solution.…”

Rapid screening of unprecedented sesquiterpenes with distinctive ring skeletons from Daphne aurantiaca employing an integrated strategy

“…The conformational analysis of 1–6 was conducted using Spartan software with Molecular Merck force field (MMFF94). 39–43 These conformers were optimized at the B3LYP/6-31G(d) level. The optimized conformers were calculated by the TDDFT method at the B3LYP/6-311++G(2d,p) level.…”