Phomopsidione nanoparticles coated contact lenses reduce microbial keratitis causing pathogens

Sahadan, Muhammad Yusoff Bin; Tong, Woei Yenn; Tan, Wen-Nee; Leong, Chean Ring; Misri, Mohamad Najib Bin; Chan, Murphy; Cheng, See Yuan; Shaharuddin, Shahrulzaman

doi:10.1016/j.exer.2018.09.011

Cited by 33 publications

(18 citation statements)

References 27 publications

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“…It may also affect the integrity of the drug if it is sensitive to the polymerisation process. b) Soaking an already formed contact lens with the drug-nanoparticles [238,239,249,252,[255][256][257]. The advantage in this approach is that it can readily be applied to commercial contact lenses, which potentially greatly lowers the barrier for commercialisation.…”

Section: Incorporation Of Nanoparticles Into Contact Lens Materialsmentioning

confidence: 99%

BCLA CLEAR – Contact lens technologies of the future

Jones

Hui

Phan

et al. 2021

Contact Lens and Anterior Eye

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Contact lenses in the future will likely have functions other than correction of refractive error. Lenses designed to control the development of myopia are already commercially available. Contact lenses as drug delivery devices and powered through advancements in nanotechnology will open up further opportunities for unique uses of contact lenses.This review examines the use, or potential use, of contact lenses aside from their role to correct refractive error. Contact lenses can be used to detect systemic and ocular surface diseases, treat and manage various ocular conditions and as devices that can correct presbyopia, control the development of myopia or be used for augmented vision. There is also discussion of new developments in contact lens packaging and storage cases.The use of contact lenses as devices to detect systemic disease has mostly focussed on detecting changes to glucose levels in tears for monitoring diabetic control. Glucose can be detected using changes in colour, fluorescence or generation of electric signals by embedded sensors such as boronic acid, concanavalin A or glucose oxidase. Contact lenses that have gained regulatory approval can measure changes in intraocular pressure to monitor glaucoma by measuring small changes in corneal shape. Challenges include integrating sensors into contact lenses and detecting the signals generated. Various techniques are used to optimise uptake and release of the drugs to the ocular surface to treat diseases such as dry eye, glaucoma, infection and allergy. Contact lenses that either mechanically or electronically change their shape are being investigated for the management of presbyopia. Contact lenses that slow the development of myopia are based upon incorporating concentric rings of plus power, peripheral optical zone(s) with add power or non-monotonic variations in power. Various forms of these lenses have shown a reduction in myopia in clinical trials and are available in various markets.

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Section: Incorporation Of Nanoparticles Into Contact Lens Materialsmentioning

confidence: 99%

BCLA CLEAR – Contact lens technologies of the future

Jones

Hui

Phan

et al. 2021

Contact Lens and Anterior Eye

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“…Various studies have reported the coating of contact lenses with silver nanoparticles to treat microbial keratitis and showed inhibition of bacterial ( Bazzaz et al, 2014 ; Shayani Rad et al, 2016 ) and fungal growth ( Huang et al, 2016 ; Liu et al, 2018 ). However, the use of a high concentration of silver nanoparticles induced cytotoxicity to the mitochondrial activity, which became unsuitable for ophthalmic application ( Bin Sahadan et al, 2019 ). Bin Sahadan et al (2019 ) have reported the coating of contact lenses with phomopsidione nanoparticles, a ketone derivative, which excellently inhibited the growth of keratitis caused by Gram-negative bacteria.…”

Section: Ocular Drug Delivery Systems To Treat Keratitismentioning

confidence: 99%

“…However, the use of a high concentration of silver nanoparticles induced cytotoxicity to the mitochondrial activity, which became unsuitable for ophthalmic application ( Bin Sahadan et al, 2019 ). Bin Sahadan et al (2019 ) have reported the coating of contact lenses with phomopsidione nanoparticles, a ketone derivative, which excellently inhibited the growth of keratitis caused by Gram-negative bacteria. Melimine, a synthetic peptide derived from protamine and melittin, increased the hydrophilicity of the contact lenses and inhibited the growth of various microbes cultured on it ( Dutta et al, 2013 ; Dutta et al, 2016a ).…”

Section: Ocular Drug Delivery Systems To Treat Keratitismentioning

confidence: 99%

Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis

et al. 2021

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Microbial keratitis is a leading cause of blindness worldwide and results in unilateral vision loss in an estimated 2 million people per year. Bacteria and fungus are two main etiological agents that cause corneal ulcers. Although antibiotics and antifungals are commonly used to treat corneal infections, a clear trend with increasing resistance to these antimicrobials is emerging at rapid pace. Extensive research has been carried out to determine alternative therapeutic interventions, and antimicrobial peptides (AMPs) are increasingly recognized for their clinical potential in treating infections. Small molecules targeted against virulence factors of the pathogens and natural compounds are also explored to meet the challenges and growing demand for therapeutic agents. Here we review the potential of AMPs, small molecules, and natural compounds as alternative therapeutic interventions for the treatment of corneal infections to combat antimicrobial resistance. Additionally, we have also discussed about the different formats of drug delivery systems for optimal administration of drugs to treat microbial keratitis.

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“…and Bhawana et al . the hydrogel with phomopsidione exhibited inhibitory activity only on Gram-negative bacteria (Fayaz et al, 2010;Bhawana et al, 2011). However, the inhibitory activity of phomopsidione on Gram-negative bacteria was previously reported earlier (Sahadan et al, 2019). Phomosidione did not target the bacterial cell wall.…”

Section: Resultsmentioning

confidence: 64%

“…The sample was filtered using a 0.22 μm syringe filter. Then, the amount of phomopsidione released was analyzed using the High-Performance Liquid Chromatogram (Sahadan et al, 2019). The mobile phase used was chloroform/methanol at a ratio of 3:7 (v/v) with an HPLC (Perkin Elmer Series 200) coupled with Breeze software.…”

Section: Drug Release Studymentioning

confidence: 99%

Phomopsidione loaded chitosan polyethylene glycol (PEG) nanocomposite dressing for pressure ulcers

Chin¹,

Tong²,

Leong³

et al.

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Pressure ulcers are commonly associated with microbial infections on the wounds which need an effective wound dressing. However, the silver dressings have shown promising result but they have toxicity and argyria. Hence, this study aimed to develop and characterize chitosan-polyethylene glycol (PEG) nanocomposite hydrogel loaded with phomopsidione as an antimicrobial dressing. The hydrogel being synthesized was analyzed with transmission and scanning electron microscopes. Drug release and mechanical properties were studied having confirmed the functional groups with Fourier transform infrared (FTIR) spectroscopy. Finally, antimicrobial activities were evaluated against the clinical wound pathogens. The developed hydrogel was soft, flexible and elastic, having nanospheres of chitosan-PEG but no sign of aggregation under the electron microscopes. Releasing of phomopsidione from the nanocomposite hydrogel was slow and gradual following the first order of kinetic. On average, 34 μg/mL phomopsidione released per hour and 67.9% active ingredients delivered into the surrounding medium over the study period. Although, the bioactivity activity of the hydrogel was narrow-spectrum, it showed significant results against all Gramnegative bacteria and Candida utilis with 99.99% reduction of microbial growth. The findings reveal that the phomopsidione loaded hydrogel has a great promise to act as an antimicrobial dressing for chronic wounds.

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Phomopsidione nanoparticles coated contact lenses reduce microbial keratitis causing pathogens

Cited by 33 publications

References 27 publications

BCLA CLEAR – Contact lens technologies of the future

BCLA CLEAR – Contact lens technologies of the future

Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis

Phomopsidione loaded chitosan polyethylene glycol (PEG) nanocomposite dressing for pressure ulcers

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