Phoenixin-14 injected intracerebroventricularly but not intraperitoneally stimulates food intake in rats

Schalla, Martha A.; Prinz, Philip; Friedrich, Tiemo; Scharner, Sophie; Kobelt, Peter; Goebel-Stengel, Miriam; Rose, Matthias; Stengel, Andreas

doi:10.1016/j.peptides.2017.08.004

Cited by 58 publications

(61 citation statements)

References 25 publications

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“…Before the experiments, they were housed five per cage at temperatures of (20–22°C) and humidity of (60%–70%) in a controlled room set to a 12‐hr light:12‐hr dark cycle and had access to standard rat pellet and water ad libitum. Both phoenixin (Schalla et al, ) and nesfatin‐1 (Oh‐I et al, ) are related to the central control of food intake. Moreover, we recently observed that nesfatin‐1 had more potent hyperventilation effect in the fed ad libitum rats than in 12 hr‐fasted rats (Ciftci et al, ).…”

Section: Methodsmentioning

confidence: 99%

Contingent role of phoenixin and nesfatin‐1 on secretions of the male reproductive hormones

et al. 2019

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Phoenixin (PNX) and nesfatin‐1 are localised in the hypothalamus and the pituitary gland. Moreover, the most of the PNX‐expressing neurons in the hypothalamus also co‐express nesfatin‐1. These outcomes may suggest that there is an interaction between PNX and nesfatin‐1, at least in terms of neuroendocrine‐mediated regulations. Hence, the study was planned to find out the effects of centrally delivered PNX and nesfatin‐1 on male sex hormones or to show the interactive association of intracerebroventricularly (ICV) injected PNX+nesfatin‐1 combination on the release of male hormones. PNX and nesfatin‐1, single or together, were delivered ICV to different male Wistar Albino rat groups. Both PNX and nesfatin‐1 induced a significant enhancement in plasma FSH, LH and testosterone without inducing any alteration in plasma GnRH in the rats. The central combinatorial treatment of both the neuropeptides produced a more potent rise in male plasma hormone levels than treating with single neuropeptide. In summary, our preliminary data show that centrally delivered PNX and nesfatin‐1 can affect plasma male hormone levels. Moreover, that the combinatorial treatment with both the neuropeptides in male rats leading to a more potent effect on the plasma male hormone levels might suggest that both these neuropeptides act synergistically in terms of regulation of male HPGA.

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Section: Methodsmentioning

confidence: 99%

Contingent role of phoenixin and nesfatin‐1 on secretions of the male reproductive hormones

et al. 2019

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“…Central administration of phoenixin-14 to male rats fed ad libitum resulted in an increase in light-phase food intake, when compared with vehicle, 22 although the total 24-hour food intake was similar, with dark-phase food intake being appropriately modulated. Analysis revealed that administration of phoenixin-14 resulted in an increase in feeding frequency, but a reduction in feed bouts.…”

Section: Feeding Behaviorsmentioning

confidence: 90%

“…This effect was not observed when phoenixin-14 was administered peripherally (intraperitoneally). 22 Furthermore, while not investigating feeding behaviors directly, Ullah et al demonstrated that in women with PCOS, circulating nesfatin-1 levels were increased in patients with PCOS, when compared with healthy controls 10 (p ¼ 0.006) and that this was consistent with phoenixin levels. While evidence surrounding nesfatin levels in women with PCOS is conflicting in the literature, 23,24 the suggestion of a relationship is interesting.…”

Section: Feeding Behaviorsmentioning

confidence: 98%

Phoenixin and Its Role in Reproductive Hormone Release

Clarke

Dhillo

2019

Semin Reprod Med

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Phoenixin is novel neuropeptide, recently identified following the description of a peptide sequence highly conserved across several animal species, including humans, cows, and pigs. Expressed both centrally in the hypothalamus and arcuate nucleus and peripherally in cardiac and gastrointestinal tissue, it appears to modulate reproductive hormone secretion in a gonadotrophin-releasing hormone–dependent manner and may also influence anxiety and memory. While there remains much to be described regarding its signaling, this review assesses the currently available literature in both animal and human studies to summarize our understanding of the physiological role of this novel neuropeptide, and its function in reproductive hormone release.

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“…injection exerted anxiolytic effects in mice [17] . In a more recent study, Schalla et al [18] reported that phoenixin by i.c.v. injection, but not intraperitoneally, exerted a centrally mediated orexigenic response in rats.…”

Section: A Signaling Molecule In the Nervous Systemmentioning

confidence: 95%

Phoenixin: a novel brain-gut-skin peptide with multiple bioactivity

et al. 2018

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In this brief review we summarize the current fndings relative to the discovery of a small peptide ligand, phoenixin (PNX). Using a bioinformatic approach, two novel peptides PNX-14 and PNX-20 containing 14 and 20 amino acids, respectively, were isolated from diverse tissues including the brain, heart, lung and stomach. Mass spectrometry analysis identified a major and minor peak corresponding to PNX-14 and PNX-20, in rat or mouse spinal cord extracts. With the use of a rabbit polyclonal antiserum, phoenixin immunoreactivity (irPNX) was detected in discrete areas of the rodent brain including several hypothalamic subnuclei and dorsal motor nucleus of the vagus. In addition, irPNX was detected in a population of sensory ganglion cells including dorsal root ganglion, nodose ganglion and trigeminal ganglion, and in cell processes densely distributed to the superficial layers of the dorsal horn, nucleus of the solitary tract and spinal trigeminal tract. irPNX cell processes were also detected in the skin and myenteric plexus, suggesting a brain-gut and/or brain-skin connection. Pharmacological studies show that PNX-14 injected subcutaneously to the nape of the neck of mice provoked dose-dependent repetitive scratching bouts directed to the back of the neck with the hindpaws. Our result suggests that the peptide PNX-14 and/or PNX-20, may serve as one of the endogenous signal molecules transducing itch sensation. Additionally, results from other laboratories show that exogenous PNX may affect a number of diverse behaviors such as memory formation, depression, reproduction, food-intake and anxiolytic-like behaviors.

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Phoenixin-14 injected intracerebroventricularly but not intraperitoneally stimulates food intake in rats

Cited by 58 publications

References 25 publications

Contingent role of phoenixin and nesfatin‐1 on secretions of the male reproductive hormones

Contingent role of phoenixin and nesfatin‐1 on secretions of the male reproductive hormones

Phoenixin and Its Role in Reproductive Hormone Release

Phoenixin: a novel brain-gut-skin peptide with multiple bioactivity

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