Phoenixin-14 concentrations are increased in association with luteinizing hormone and nesfatin-1 concentrations in women with polycystic ovary syndrome

Ullah, Kalim; Rahman, Tanzil Ur; Wu, Dandan; Lin, Xian-Hua; Liu, Ye; Guo, Xiaoyan; Leung, Peter C.K.; Zhang, Runju; Huang, He‐Feng; Sheng, Jian‐Zhong

doi:10.1016/j.cca.2017.06.013

Cited by 42 publications

(40 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The report showing that nesfatin‐1‐modulated PNX expression in the hypothalamic nuclei by affecting plasma LH levels might suggest as well that the two neuropeptides could work together to regulate HPGA (Palasz et al, ). Moreover, it has also been reported that there is a significant positive correlation of plasma PNX and nesfatin‐1 levels in women affected by polycystic ovarian syndrome (Ullah et al, ). Both PNX (Schalla & Stengel, ) and nesfatin‐1 (Pan, Hsuchou, & Kastin, ) can cross a relatively impermeable blood–brain barrier.…”

Section: Discussionmentioning

confidence: 94%

Contingent role of phoenixin and nesfatin‐1 on secretions of the male reproductive hormones

et al. 2019

View full text Add to dashboard Cite

Phoenixin (PNX) and nesfatin‐1 are localised in the hypothalamus and the pituitary gland. Moreover, the most of the PNX‐expressing neurons in the hypothalamus also co‐express nesfatin‐1. These outcomes may suggest that there is an interaction between PNX and nesfatin‐1, at least in terms of neuroendocrine‐mediated regulations. Hence, the study was planned to find out the effects of centrally delivered PNX and nesfatin‐1 on male sex hormones or to show the interactive association of intracerebroventricularly (ICV) injected PNX+nesfatin‐1 combination on the release of male hormones. PNX and nesfatin‐1, single or together, were delivered ICV to different male Wistar Albino rat groups. Both PNX and nesfatin‐1 induced a significant enhancement in plasma FSH, LH and testosterone without inducing any alteration in plasma GnRH in the rats. The central combinatorial treatment of both the neuropeptides produced a more potent rise in male plasma hormone levels than treating with single neuropeptide. In summary, our preliminary data show that centrally delivered PNX and nesfatin‐1 can affect plasma male hormone levels. Moreover, that the combinatorial treatment with both the neuropeptides in male rats leading to a more potent effect on the plasma male hormone levels might suggest that both these neuropeptides act synergistically in terms of regulation of male HPGA.

show abstract

Section: Discussionmentioning

confidence: 94%

Contingent role of phoenixin and nesfatin‐1 on secretions of the male reproductive hormones

et al. 2019

View full text Add to dashboard Cite

show abstract

“…One can therefore finally conclude that only brain-derived PNX can play a significant role in the central control of food intake. Noteworthy, an elevated plasma PNX-14 level in women with polycystic ovary syndrome (PCOS) suggests a potential involvement of PNX in the pathogenesis of this hormonally-related disease(Ullah et al 2017). A valuable study byJiang et al (2015a) proved that PNX-14 acts as a potent anxiolytic factor in male mice when administered centrally.…”

mentioning

confidence: 99%

The potential role of the novel hypothalamic neuropeptides nesfatin-1, phoenixin, spexin and kisspeptin in the pathogenesis of anxiety and anorexia nervosa

Pałasz

Janas–Kozik

Borrow

et al. 2018

Neurochemistry International

View full text Add to dashboard Cite

Due to the dynamic development of molecular neurobiology and bioinformatic methods several novel brain neuropeptides have been identified and characterized in recent years. Contemporary techniques of selective molecular detection e.g. in situ Real-Time PCR, microdiffusion and some bioinformatics strategies that base on searching for single structural features common to diverse neuropeptides such as hidden Markov model (HMM) have been successfully introduced. A convincing majority of neuropeptides have unique properties as well as a broad spectrum of physiological activity in numerous neuronal pathways including the hypothalamus and limbic system. The newly discovered but uncharacterized regulatory factors nesfatin-1, phoenixin, spexin and kisspeptin have the potential to be unique modulators of stress responses and eating behaviour. Accumulating basic studies revelaed an intriguing role of these neuropeptides in the brain pathways involved in the pathogenesis of anxiety behaviour. Nesfatin-1, phoenixin, spexin and kisspeptin may also distinctly affect the energy homeostasis and modulate food intake not only at the level of hypothalamic centres. Moreover, in patients suffered from anxiety and anorexia nervosa a significant, sex-related changes in the plasma neuropeptide levels occurred. It should be therefore taken into account that the targeted pharmacomodulation of central peptidergic signaling may be potentially helpful in the future treatment of certain neuropsychiatric and metabolic disorders. This article reviews recent evidence dealing with the hypothetical role of these new factors in the anxiety-related circuits and pathophysiology of anorexia nervosa.

show abstract

“…They observed that phoenixin-14 levels on days 2 to 3 of the spontaneous menstrual cycle were significantly higher in women with PCOS when compared with healthy controls. 10 Correlation analyses showed phoenixin-14 was positively correlated with LH, follicle-stimulating hormone, total testosterone, and BMI in women with PCOS (n ¼ 41). 10 Given that phoenixin signaling has been demonstrated at the level of the ovary, and that phoenixin delayed estrus, Nguyen and colleagues investigated the role of phoenixin and its receptor on folliculogenesis.…”

Section: Phoenixin and Its Role In Reproductionmentioning

confidence: 97%

“…10 Correlation analyses showed phoenixin-14 was positively correlated with LH, follicle-stimulating hormone, total testosterone, and BMI in women with PCOS (n ¼ 41). 10 Given that phoenixin signaling has been demonstrated at the level of the ovary, and that phoenixin delayed estrus, Nguyen and colleagues investigated the role of phoenixin and its receptor on folliculogenesis. 11 Using human ovarian tissue from women aged 19 to 32 years, undergoing surgery for cervical cancer, they demonstrated expression of phoenixin and its receptor, GPR173, in human ovarian follicles.…”

Section: Phoenixin and Its Role In Reproductionmentioning

confidence: 97%

Phoenixin and Its Role in Reproductive Hormone Release

Clarke

Dhillo

2019

Semin Reprod Med

View full text Add to dashboard Cite

Phoenixin is novel neuropeptide, recently identified following the description of a peptide sequence highly conserved across several animal species, including humans, cows, and pigs. Expressed both centrally in the hypothalamus and arcuate nucleus and peripherally in cardiac and gastrointestinal tissue, it appears to modulate reproductive hormone secretion in a gonadotrophin-releasing hormone–dependent manner and may also influence anxiety and memory. While there remains much to be described regarding its signaling, this review assesses the currently available literature in both animal and human studies to summarize our understanding of the physiological role of this novel neuropeptide, and its function in reproductive hormone release.

show abstract

Phoenixin-14 concentrations are increased in association with luteinizing hormone and nesfatin-1 concentrations in women with polycystic ovary syndrome

Cited by 42 publications

References 20 publications

Contingent role of phoenixin and nesfatin‐1 on secretions of the male reproductive hormones

Contingent role of phoenixin and nesfatin‐1 on secretions of the male reproductive hormones

The potential role of the novel hypothalamic neuropeptides nesfatin-1, phoenixin, spexin and kisspeptin in the pathogenesis of anxiety and anorexia nervosa

Phoenixin and Its Role in Reproductive Hormone Release

Contact Info

Product

Resources

About