Phoenix dactylifera linn as a potential novel anti-oxidant in treating major opioid toxicity.

Sani, Ibrahim; Bakar, Nor Hidayah Abu; Rohin, Mohd Adzim Khalili; Idris, Suleiman; Umar, Maryam Ibrahim; Mohamad, Nasir

doi:10.7324/japs.2015.50826

Cited by 14 publications

(12 citation statements)

References 44 publications

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“…Dates also exhibit strong potential against chronic inflammatory diseases and are used to cure anti‐inflammatory disorders including arthritis, asthma, chronic obstructive pulmonary diseases, and gastrointestinal disturbances (Yasin, El‐Fawal, & Mousa, 2015). Due to anti‐inflammatory potential, various constituents of date fruits are also used in the pharmaceutical industry in the manufacturing of pain relief medicine such as part of paracetamol and ibuprofen (El‐Far et al., 2019; Sani et al., 2015). These biologically active substances exert anti‐inflammatory potential by inhibiting unwanted biochemical reactions.…”

Section: Biological and Therapeutic Potential Of Datesmentioning

confidence: 99%

Functional food and nutra‐pharmaceutical perspectives of date ( Phoenix dactylifera L.) fruit

et al. 2020

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Date palm counts among the oldest fruit crops of the world and is mainly cultivated for its highly nutritious fruits consumed as a staple food in many countries, especially in the Gulf region. Dates are enriched with numerous therapeutic bioactives and functional compounds such as phenolics, flavonols, carotenoids, minerals, and vitamins that not only provide an appreciable amount of energy required for the human body but also act as an effective therapeutic agent against several diseases. This review aimed to provide a deep insight into the nutritional as well as phytochemicals profile of date fruit and its seeds in order to explore their biological (anti‐cancer, anti‐diabetic, cardio‐protective, anti‐inflammatory properties), functional food, and nutra‐pharmaceutical attributes. Practical applications This review provides updated information regarding the date fruits and seeds phytochemicals composition together with highlighting dates potential as a natural therapeutic agent against several diseases. The study also urges the importance of consuming dates as a great package to live a healthy life due to the functional food and nutraceutical properties of this valuable fruit. The study also provides information first time as recommending dates to cope with the hidden hunger or micronutrient deficiency faced by the third world inhabitants. Hence, the review may further help the industry and researchers to explore the potential of dates for future medicinal and nutra‐pharmaceutical applications.

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Section: Biological and Therapeutic Potential Of Datesmentioning

confidence: 99%

Functional food and nutra‐pharmaceutical perspectives of date ( Phoenix dactylifera L.) fruit

et al. 2020

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“…dactylifera are popularly used to manage a variety of ailments, including neurological diseases, memory deterioration, paralysis, hyperthermia, and coma. 13 Date fruits and seeds, in the form of powder, pulp, and infusion, are commonly used in research to treat atherosclerosis, malignancy, asthenia, pulmonary ailments, and throat infections. Date fruits and seeds are also used as an antidiarrheic, hypoglycemic, expectorant, tonic, aphrodisiac, and mouthwash.…”

Section: Introductionmentioning

confidence: 99%

Ajwa seeds (Phoenix dactylifera L.) suspension exerted antidiabetic and antihyperlipidemic effects against streptozotocin-induced diabetes in rats by downregulating insulin expression in the pancreatic beta islets

Alahmadi

Banayah

2021

J. contemp. med. sci.

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Objectives: This study investigated the antidiabetic and antihyperlipidemic effects of the powdered seeds of Ajwa Al-Madina in streptozotocin (STZ)-induced diabetes in rats. Besides investigating the possible underlying mechanisms. Methods: Rats were assigned to one of six groups (n = 5) as follows: normal control, vehicle control, Ajwa seeds control, diabetic control, Diabetic + Metformin, and Diabetic + Ajwa seeds. Metformin and Ajwa seeds were injected into rats orally via oral gavage 6 days/week along 4 weeks period Results: Ajwa seeds decreased fasting serum glucose, increased fasting serum insulin and decreased fasting serum triglycerides cholesterol, low-density lipoprotein, and increased fasting serum high-density lipoprotein. Besides, it upregulated insulin protein immunoexpression in the beta cells of Langerhans islets. Ajwa seed also preserved the normal histological structure of the pancreatic beta cells tissue. Conclusion: Ajwa seeds produced significant hypoglycemic and hypolipidemic effects in diabetic rats mainly through enhancement of insulin secretion. The plant is a promising adjunctive therapy in diabetes mellitus treatment.

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“…The maceration extraction method was chosen because the cold extraction technique is expected to attract more antioxidant compounds (polyphenols) where polyphenols are compounds that are not resistant to heat, so it is hoped that the extraction process will not damage the active compounds. (Sani et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Synergism Test of Date (Phoenix Dactylifera L.) and Raw Tempe on Antioxidant Activity

Putri¹,

Rani²

2021

Jurnal Mitra Kesehatan

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Introduction: Dates and tempeh are foods that both contain antioxidant compounds. Antioxidant compounds such as flavonoids and isoflavones are known to be found in dates and tempeh. This study was conducted to see how much antioxidant activity contained in dates and tempeh and how the effect of dates and tempeh consumed simultaneously on the increase in total antioxidant activity. Method: This study uses a direct experimental design with prospective data collection. The selected samples were dates with the type of sukkari and tempeh wrapped in plastic. Data processing was carried out using a simple linear regression statistical method. Results: The DPPH test method with UV-Visible Spectrophotometry instrument showed the results of the % inhibition value of dates fruit of 39.99% and tempeh of 24.52%. Testing the synergistic effect using 7 treatments showed that the treatment with a ratio of 50:50 had a higher % inhibition value than the other treatments, which showed that consuming dates and tempeh in a ratio of 50:50 could provide a synergistic effect on antioxidant activity. Conclusion The results obtained indicate that both samples, both dates and tempeh have high antioxidant activity, consuming both simultaneously can increase antioxidant activity. So it can be concluded that there is an effect on the synergistic effect of antioxidant activity of dates and tempeh which are consumed simultaneously. It is recommended to conduct research on the antioxidant activity of dates and tempeh using other test methods, and further research on the formulation of the preparation or clinical trials using mice.

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Phoenix dactylifera linn as a potential novel anti-oxidant in treating major opioid toxicity.

Cited by 14 publications

References 44 publications

Functional food and nutra‐pharmaceutical perspectives of date ( Phoenix dactylifera L.) fruit

Functional food and nutra‐pharmaceutical perspectives of date ( Phoenix dactylifera L.) fruit

Ajwa seeds (Phoenix dactylifera L.) suspension exerted antidiabetic and antihyperlipidemic effects against streptozotocin-induced diabetes in rats by downregulating insulin expression in the pancreatic beta islets

Synergism Test of Date (Phoenix Dactylifera L.) and Raw Tempe on Antioxidant Activity

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