Phoenix dactylifera L. sap enhances wound healing in Wistar rats: Phytochemical and histological assessment

Abstract

16The sap of the date palm "Lagmi" is a clear liquid, rich in sugars and minerals, with a pleasant flavour. Folk 17 remedies based on the use of "Lagmi" for wound healing are still practiced. However, no studies investigated the 18 relevance of "Lagmi" for wound healing. Therefore, the aim of this study was to identify the in vivo healing 19properties of "lagmi" on mechanically wounded wistar rats. Injured rats were divided into three groups: a first 20 group treated by "lagmi", a second reference group processed by CICAFLORA® and a third untreated control

In vivo wound healing potential and HPLC-PDA-ESI-MS profiling ofZizyphus lotusL. (Desf.) leaves methanol extract

“…Flavonoids and other polyphenols appear to be responsible for the enhanced wound contraction rate and shortened period of epithelialization due to their astringent, antimicrobial, antioxidant, anti‐inflammatory, and antiallergic properties which can, to a great extent, promote the wound healing process (Abdennabi et al, ; Trevisanato & Kim, ). The wound healing activity observed for Z. lotus could be mainly attributable to its constituents; procyanidins, catechin, kaempferol‐3‐O‐rutinoside and quercetin‐3‐O‐rutinoside.…”

“…enhanced wound contraction rate and shortened period of epithelialization due to their astringent, antimicrobial, antioxidant, antiinflammatory, and antiallergic properties which can, to a great extent, promote the wound healing process(Abdennabi et al, 2016;Trevisanato & Kim, 2000). The wound healing activity observed for Z. lotus could be mainly attributable to its constituents; procyanidins, catechin, kaempferol-3-O-rutinoside and quercetin-3-O-rutinoside.Because procyanidins have been reported to stimulate skin cell activity procyanidin B2 from the aqueous extract of Combretum mucronatum leaves was tested concerning its influence on the keratinocytes differentiation.…”

Effectiveness of Traditional KSM Dressing and TJ Honey on Healing Acute Wounds in Rats

“…In Indonesia, the public utilizes the syrup from dates to treat several infectious diseases for instance, compressing chronic wounds [12,13]. The literature study reports that dates can accelerate wound healing while other studies report that dates are very effective as an antiinflammatory and antimicrobial agent in that they accelerate cell proliferation and contribute to the healing of wounds [14][15][16][17]. In the results of a chemical analysis on dates, several contents, including minerals, flavonoids and high polyphenols can kill bacteria such as staphylococcus aureus and pseudomonas aeruginosa [14].…”

“…The literature study reports that dates can accelerate wound healing while other studies report that dates are very effective as an antiinflammatory and antimicrobial agent in that they accelerate cell proliferation and contribute to the healing of wounds [14][15][16][17]. In the results of a chemical analysis on dates, several contents, including minerals, flavonoids and high polyphenols can kill bacteria such as staphylococcus aureus and pseudomonas aeruginosa [14]. The extensive characterization of phenolic compounds and flavonoids constitutes an important source of anti-inflammatory compounds and is quite supportive in the wound-healing process [18].…”

“…The extensive characterization of phenolic compounds and flavonoids constitutes an important source of anti-inflammatory compounds and is quite supportive in the wound-healing process [18]. Honey and dates are excellent sources of nutrition for bodily health as well as wound healing, the latter of which is a complex process that requires optimum wound care when considering an effective dressing product for the healing process that does not cause resistance to bacteria [9,14,15]. Wound care continues to evolve and wound care professionals are faced with several challenges.…”