Phlorotannin supplement decreases wake after sleep onset in adults with self‐reported sleep disturbance: A randomized, controlled, double‐blind clinical and polysomnographic study

Um, Min Young; Kim, Jin Young; Han, Jae Hyeon; Kim, Jin‐Kyung; Yang, Hyejin; Yoon, Minseok; Kim, Jiyoung; Kang, Seung Wan; Cho, Suengmok

doi:10.1002/ptr.6019

Cited by 32 publications

(35 citation statements)

References 31 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over the last decade, the biological properties of phlorotannins have been widely investigated, and research on phlorotannins is steadily growing. In our previous studies [ 11 , 17 ], the sleep-promoting effects and GABAergic signaling mechanisms of phlorotannins were demonstrated for the first time. Phlorotannin preparations have been shown to significantly decrease sleep latency and increase NREMS in C57BL/6N mice via the GABA A -BZD receptors [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…The sleep-promoting effects of phlorotannin supplements at 500 mg/kg were comparable to those of the positive control, diazepam at 6 mg/kg [ 11 ]. In addition, in a randomized, double-blind, placebo-controlled clinical trial of 20 volunteers [ 17 ], phlorotannin supplements significantly decreased wakefulness after sleep onset (phlorotannin vs. placebo, −25.5 ± 30.5 vs. −1.7 ± 14.9; p = 0.045) and total wake time (phlorotannin vs. placebo, −0.9 ± 3.0 vs. −6.1 ± 6.8; p = 0.048) compared to the placebo.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Triphlorethol A, a Dietary Polyphenol from Seaweed, Decreases Sleep Latency and Increases Non-Rapid Eye Movement Sleep in Mice

Yoon

Cho

2018

Marine Drugs

Self Cite

View full text Add to dashboard Cite

In our previous studies, we have demonstrated that marine polyphenol phlorotannins promote sleep through the benzodiazepine site of the gamma-aminobutyric acid type A (GABAA) receptors. In this follow-up study, the sleep-promoting effects of triphlorethol A, one of the major phlorotannin constituents, were investigated. The effect of triphlorethol A on sleep-wake architecture and profiles was evaluated based on electroencephalogram and electromyogram data from C57BL/6N mice and compared with the well-known hypnotic drug zolpidem. Oral administration of triphlorethol A (5, 10, 25, and 50 mg/kg) dose-dependently decreased sleep latency and increased sleep duration during pentobarbital-induced sleep in imprinting control region mice. Triphlorethol A (50 mg/kg) significantly decreased sleep latency and increased the amount of non-rapid eye movement sleep (NREMS) in C57BL/6N mice, without affecting rapid eye movement sleep (REMS). There was no significant difference between the effects of triphlorethol A at 50 mg/kg and zolpidem at 10 mg/kg. Triphlorethol A had no effect on delta activity (0.5–4 Hz) of NREMS, whereas zolpidem significantly decreased it. These results not only support the sleep-promoting effects of marine polyphenol phlorotannins, but also suggest that the marine polyphenol compound triphlorethol A is a promising structure for developing novel sedative hypnotics.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Triphlorethol A, a Dietary Polyphenol from Seaweed, Decreases Sleep Latency and Increases Non-Rapid Eye Movement Sleep in Mice

Yoon

Cho

2018

Marine Drugs

Self Cite

View full text Add to dashboard Cite

show abstract

“…The methods employed to measure sleep outcomes varied across studies. Seven studies used subjective measures (i.e., diaries/logbooks and sleep questionnaires) [31][32][33][34][35][36][37], while one study used PSG/EEG [38,39], and five studies used a combination of PSG/EEG or actigraphy, and subjective measures [39][40][41][42][43].…”

Section: Dietary Supplementsmentioning

confidence: 99%

“…However, the ingestion of pure resveratrol (a stilbenoid) elicited no effect on sleep in young adults over a 28-day period [36]. On the other hand, it was found that a group of poor sleepers who were administered phlorotannin (a supplement derived from brown seaweed) experienced decreased waking after sleep onset and total wake time compared with those administered the placebo [41].…”

Section: Polyphenolsmentioning

confidence: 99%

Effects of Diet on Sleep: A Narrative Review

et al. 2020

View full text Add to dashboard Cite

Many processes are involved in sleep regulation, including the ingestion of nutrients, suggesting a link between diet and sleep. Aside from studies investigating the effects of tryptophan, previous research on sleep and diet has primarily focused on the effects of sleep deprivation or sleep restriction on diet. Furthermore, previous reviews have included subjects with clinically diagnosed sleep-related disorders. The current narrative review aimed to clarify findings on sleep-promoting foods and outline the effects of diet on sleep in otherwise healthy adults. A search was undertaken in August 2019 from the Cochrane, MEDLINE (PubMed), and CINAHL databases using the population, intervention, control, outcome (PICO) method. Eligible studies were classified based on emerging themes and reviewed using narrative synthesis. Four themes emerged: tryptophan consumption and tryptophan depletion, dietary supplements, food items, and macronutrients. High carbohydrate diets, and foods containing tryptophan, melatonin, and phytonutrients (e.g., cherries), were linked to improved sleep outcomes. The authors posit that these effects may be due in part to dietary influences on serotonin and melatonin activity.

show abstract

“…In our previous studies [12,13,14], we reported the sleep-promoting effects and action mechanism of phlorotannins. A standardized phlorotannin supplement (PS, 500 mg/kg, administered per os (p.o.))…”

Section: Introductionmentioning

confidence: 99%

A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice

et al. 2019

Self Cite

View full text Add to dashboard Cite

In our previous studies, a standardized phlorotannin (brown seaweed polyphenol) supplement (PS) exhibited sleep-promoting effects via type A γ-aminobutyric acid-benzodiazepine receptors in mice. In addition, in human clinical trials, it decreased wake after sleep onset in adults with sleep disturbance. In this follow-up study, we investigated whether PS attenuates caffeine-induced sleep disruption in mice. The effects of PS were evaluated in a caffeine model by analyzing sleep architecture based on electroencephalogram and electromyogram findings, and were compared with the effects of a well-known sedative-hypnotic drug zolpidem (ZPD). As expected, oral administration of caffeine (25 mg/kg) significantly increased sleep latency and decreased the amount of non-rapid eye movement sleep (NREMS). In the caffeine + PS and caffeine + ZPD groups, PS (500 mg/kg) attenuated caffeine-induced sleep disruption, and its effects were comparable with those of ZPD (10 mg/kg). In particular, PS inhibited the arousal effects of caffeine without change in delta activity during NREMS, whereas ZPD produced a decrease in the delta activity. Considering global trends in coffee and energy drink consumption, our finding suggest that PS may be useful to relieve transitory insomnia symptoms caused by caffeine consumption, unlike the prescription drug ZPD.

show abstract

Phlorotannin supplement decreases wake after sleep onset in adults with self‐reported sleep disturbance: A randomized, controlled, double‐blind clinical and polysomnographic study

Cited by 32 publications

References 31 publications

Triphlorethol A, a Dietary Polyphenol from Seaweed, Decreases Sleep Latency and Increases Non-Rapid Eye Movement Sleep in Mice

Triphlorethol A, a Dietary Polyphenol from Seaweed, Decreases Sleep Latency and Increases Non-Rapid Eye Movement Sleep in Mice

Effects of Diet on Sleep: A Narrative Review

A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice

Contact Info

Product

Resources

About