Phloroglucinol derivatives from Hypericum japonicum

Ishiguro, Kyoko; Nagata, Satoko; Fukumoto, Hisae; Yamaki, Masae; Isoi, Koichiro

doi:10.1016/s0031-9422(00)94784-8

Cited by 42 publications

(38 citation statements)

References 7 publications

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“…The results of these studies add to growing knowledge of the antimicrobial properties of acylphloroglucinol metabolites. Other studies have reported acylphloroglucinol derivatives possessing antimicrobial activity against staphylococci (Ishiguro et al ., ; Schempp et al ., ; Winkelmann et al ., , ; Gibbons et al ., ; Pecchio et al ., ; Henry et al ., ). A study by Socolsky et al .…”

Section: Resultsmentioning

confidence: 99%

Inhibition of Bacterial Growth and Biofilm Production by Constituents from Hypericum spp.

Sarkisian

Janssen

Matta

et al. 2011

Phytotherapy Research

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Biofilm embedded bacterial pathogens such as Staphylococcus spp., Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii are difficult to eradicate and are major sources of bacterial infections. New drugs are needed to combat these pathogens. Hypericum is a plant genus that contains species known to have antimicrobial properties. However, the specific constituents responsible for the antimicrobial properties are not entirely known, nor have most compounds been tested as inhibitors of biofilm development. The investigation presented here tested seven secondary metabolites isolated from the species Hypericum densiflorum, Hypericumellipticum, Hypericum prolificum and Hypericum punctatum as inhibitors of bacterial growth and biofilm production. Assays were conducted against Staphylococcus epidermidis, Staphylococcusaureus, clinical methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Escherichia coli, and Acinetobacter baumannii. Five of the seven compounds demonstrated growth inhibition against the Gram-positive bacteria with minimum inhibitory concentrations (MIC) ranging from 1.95 μg/mL to 7.81 μg/mL. Four of the secondary metabolites inhibited biofilm production by certain Gram-positive strains at sub-MIC concentrations.

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Section: Resultsmentioning

confidence: 99%

Inhibition of Bacterial Growth and Biofilm Production by Constituents from Hypericum spp.

Sarkisian

Janssen

Matta

et al. 2011

Phytotherapy Research

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“…[1][2][3][4] The qualitative and quantitative distribution of hypericin and pseudohypericin, naturally occurring red pigments in this genus, have been very intensively studied, not only because of their antidepressive 5 and antiviral activities, but also because they are chemotaxonomically important for the infrageneric classification of Hypericum. [6][7][8][9] The most-studied species is H. perforatum; also, its essential oil was investigated in species harvested not only in France, Portugal and Italy [10][11][12][13][14] but also in India and Turkey.…”

Section: Introductionmentioning

confidence: 99%

Volatile constituents of the leaves and flowers of Hypericum triquetrifolium Turra

Bertoli

Menichini

Mazzetti

et al. 2003

Flavour & Fragrance J

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The flower and leaf oil of Hypericum triquetrifolium Turra (Guttiferae, Hypericoideae) from Calabria (Italy) were studied by GC and GC-MS. The major components identified in each oil were n-nonane (8%, 15%), β-pinene (8%, 4%), α-pinene (13%, 10%), myrcene (16%, 5%), β-caryophyllene (5%, 11%), germacrene-D (10%, 13%), sabinene (13%, 3%) and caryophyllene oxide (5%, 12%) in the leaf and flower oils, respectively. The aerial parts of the same plant were also analysed by SPME. The SPME analysis showed higher yields of undecane (14%, 10%) and β-caryophyllene (14%, 10%) in comparison with the corresponding hydrodistillation oils, in addition to α-pinene, β-pinene, sabinene and myrcene, amounting to (9%, 6%), (7%, 4%), (1%, 9%), (1%, 10%) for the leaves and flowers, respectively.

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“…Recently, antifungal [2], antibiotic [3], antiviral [4], and anticancer [5] compounds were isolated from these species.…”

Section: Introductionmentioning

confidence: 99%

Sub‐and Supercritical CO₂‐Extraction of Hypericum perforatum L.

Šmelcerović¹,

Lepojević

Djordjević³

2004

Chem Eng & Technol

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The extraction of Hypericum perforatum L. by liquid carbon dioxide (p = 80 bar, t = 15 C) gave almost the same extract yield (1 %, w/w) as by supercritical (p = 100 bar, t = 40 C) carbon dioxide, containing the same percentages of essential oil (about 6.4 %, w/w). The increase of the extract yield at higher pressure (250 to 350 bar) is due to the increase of extragent density, i.e., solubility. By increasing the grinding degree of the drug, a higher extract yield is obtained in the supercritical range under high pressure. GC-MS analysis of the extract composition showed that the non-terpene compounds have the highest contribution. The oil content in the drug, determined by steam distillation, was 0.058 %, w/w. The oil content in the extracts, calculated for the drug, was significantly higher (1.2 to 1.9 times).

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Phloroglucinol derivatives from Hypericum japonicum

Cited by 42 publications

References 7 publications

Inhibition of Bacterial Growth and Biofilm Production by Constituents from Hypericum spp.

Inhibition of Bacterial Growth and Biofilm Production by Constituents from Hypericum spp.

Volatile constituents of the leaves and flowers of Hypericum triquetrifolium Turra

Sub‐and Supercritical CO₂‐Extraction of Hypericum perforatum L.

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Phloroglucinol derivatives from Hypericum japonicum

Cited by 42 publications

References 7 publications

Inhibition of Bacterial Growth and Biofilm Production by Constituents from Hypericum spp.

Inhibition of Bacterial Growth and Biofilm Production by Constituents from Hypericum spp.

Volatile constituents of the leaves and flowers of Hypericum triquetrifolium Turra

Sub‐and Supercritical CO2‐Extraction of Hypericum perforatum L.

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Sub‐and Supercritical CO₂‐Extraction of Hypericum perforatum L.