Phloretin loaded chitosan nanoparticles augments the pH-dependent mitochondrial-mediated intrinsic apoptosis in human oral cancer cells

Mariadoss, Arokia Vijaya Anand; Vinayagam, Ramachandran; Senthilkumar, Vijayalakshmi; Paulpandi, Manickam; Murugan, Kadarkarai; Xu, Baojun; Gothandam, Kodiveri Muthukaliannan; Kotakadi, Venkata Subbaiah; Ernest, David

doi:10.1016/j.ijbiomac.2019.03.031

Cited by 75 publications

(58 citation statements)

References 46 publications

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“…Nanomedicine is an emerging form of treatment that is dedicated to alternative drug delivery and improved therapeutic efficacy, while reducing harmful side Oxidative Medicine and Cellular Longevity effects on normal tissues. New nanoparticle systems with highly flexible and rapid drug design and production capabilities can be created, which can be designed based on the genetic characteristics of tumors; therefore, making the drug selection for individual patient treatment and overcoming multiple forms of multidrug resistance look promising and open up new prospects for cancer treatment [262][263][264][265][266][267][268]. The effect of metal nanoparticles on ROS concentration has been shown to play a role in both radiosensitization and radioprotection.…”

Section: Application Of the Nanoparticle System Based On Rosmentioning

confidence: 99%

ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer

Huang

Pan

2020

Oxidative Medicine and Cellular Longevity

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Head and neck cancer is a highly genetic and metabolic heterogeneous collection of malignancies of the lip, oral cavity, salivary glands, pharynx, esophagus, paranasal sinuses, and larynx with five-year survival rates ranging from 12% to 93%. Patients with head and neck cancer typically present with advanced stage III, IVa, or IVb disease and are treated with comprehensive modality including chemotherapy, radiotherapy, and surgery. Despite advancements in treatment modality and technique, noisome recurrence, invasiveness, and resistance as well as posttreatment complications severely influence survival rate and quality of life. Thus, new therapeutic strategies are urgently needed that offer enhanced efficacy with less toxicity. ROS in cancer cells plays a vital role in regulating cell death, DNA repair, stemness maintenance, metabolic reprogramming, and tumor microenvironment, all of which have been implicated in resistance to chemo-/radiotherapy of head and neck cancer. Adjusting ROS generation and elimination to reverse the resistance of cancer cells without impairing normal cells show great hope in improving the therapeutic efficacy of chemo-/radiotherapy of head and neck cancer. In the current review, we discuss the pivotal and targetable redox-regulating system including superoxide dismutases (SODs), tripeptide glutathione (GSH), thioredoxin (Trxs), peroxiredoxins (PRXs), nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/keap1), and mitochondria electron transporter chain (ETC) complexes and their roles in regulating ROS levels and their clinical significance implicated in chemo-/radiotherapy of head and neck cancer. We also summarize several old drugs (referred to as the non-anti-cancer drugs used in other diseases for a long time) and small molecular compounds as well as natural herbs which effectively modulate cellular ROS of head and neck cancer to synergize the efficacy of conventional chemo-/radiotherapy. Emerging interdisciplinary techniques including photodynamic, nanoparticle system, and Bio-Electro-Magnetic-Energy-Regulation (BEMER) therapy are promising measures to broaden the potency of ROS modulation for the benefit of chemo-/radiotherapy in head and neck cancer.

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Section: Application Of the Nanoparticle System Based On Rosmentioning

confidence: 99%

ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer

Huang

Pan

2020

Oxidative Medicine and Cellular Longevity

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“…[ 46 ] Interestingly, phytochemicals, such as 6‐paradol and phloretin, enhance antioxidants and modulate several signaling molecules in DMBA‐exposed oral cancer models. [ 47‐49 ]…”

Section: Discussionmentioning

confidence: 99%

Betulin ameliorates 7,12‐dimethylbenz(a)anthracene‐induced rat mammary cancer by modulating MAPK and AhR/Nrf‐2 signaling pathway

Zhang

Zhou

Sun

et al. 2021

J Biochem & Molecular Tox

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The aim of the present study is to explore the preventive efficacy of betulin (BE) in 7,12-dimethylbenz(a)anthracene (DMBA)-administered mammary cancer by modulating Ahr/Nrf2 signaling in experimental models. The mammary cancer was stimulated by the addition of DMBA (25 mg/kg/b.Wt) mixed in 1 ml of vehicle solution (sunflower oil and saline 1:1) through subcutaneous injection. The DMBA-exposed mammary tumor models showed low bodyweight, elevated quantities of lipid peroxidation molecules (TBARS and LOOH), and low enzymatic (GPx, SOD, and CAT), and nonenzymatic (GSH, vitamin C, and vitamin E) antioxidant activities in plasma and mammary tissues. Moreover, histopathological studies confirmed that invasive ductal carcinoma was observed in DMBA-induced mammary tissue of the experimental model. Dietary oral supplementation of BE prevents the loss of bodyweight, overproduces lipid peroxidation, and restores the antioxidant activities in DMBA-exposed experimental animals. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a crucial antioxidant protein that involves preventing numerous cancers. Therefore, Nrf2-associated signaling concern is a significant target for preventing mammary cancer. This study observed an increased expression of MAPKs, Keap1, ARNT, AhR, and CYP1A1, whereas decreased expression of HO-1 and Nrf2 in DMBA-induced cancer-bearing experimental animals. The oral supplementation of BE effectively modulates the expression of MAPKs, AhR/Nrf2-associated protein expressions in DMBA-exposed experimental animals. This current study concluded that BE is a strong antioxidant, which triggers the MAPKs-mediated oxidative stress and inhibits proliferative markers by restoring the activity of Nrf2 signaling.

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“…Around half a million people are diagnosed with oral cancer worldwide, and approximately 150,000 patients pass away yearly [ 203 ]. Early and accurate diagnosis allows a proper treatment, resulting in less morbidity and better prognosis [ 204 ].…”

Section: Head Neck and Oral Cancermentioning

confidence: 99%

“…A wide variety of NPs were proven to be effective against a number of oral cancer cell lines, including human Caucasian dysplastic oral keratinocytes (DOK) [ 205 , 207 ], mouth epidermoid carcinoma (KB) [ 203 , 208 , 209 , 210 , 211 , 212 ], murine AT-84 oral squamous carcinoma cells [ 213 ], oral squamous cancer cell lines of Asian origin (ORL-48 and ORL-115) [ 214 ], human oral squamous cell carcinoma lines (PE/CA-PJ15 [ 215 ], OEC-M1 [ 216 ], HSC2 [ 217 ], YD-9 [ 218 ], SAS [ 219 , 220 ], HSC4 [ 1 , 220 ], KOSC [ 220 ], HSC3 [ 204 , 221 , 222 ], HSC-3-M3 [ 7 ], Ca9-22 [ 223 ], CAL 27 [ 222 , 223 , 224 , 225 , 226 , 227 ], SCC131 [ 228 ], SCC4 [ 222 , 228 ], VB6 [ 229 ], and H357 [ 229 , 230 , 231 ]), human tongue carcinoma cell lines (SCC-9 [ 232 , 233 , 234 ], SCC-25 [ 224 , 230 , 233 , 235 ], SCC-15 […”

Section: Head Neck and Oral Cancermentioning

confidence: 99%

Nanoparticles in Dentistry: A Comprehensive Review

2021

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In recent years, nanoparticles (NPs) have been receiving more attention in dentistry. Their advantageous physicochemical and biological properties can improve the diagnosis, prevention, and treatment of numerous oral diseases, including dental caries, periodontal diseases, pulp and periapical lesions, oral candidiasis, denture stomatitis, hyposalivation, and head, neck, and oral cancer. NPs can also enhance the mechanical and microbiological properties of dental prostheses and implants and can be used to improve drug delivery through the oral mucosa. This paper reviewed studies from 2015 to 2020 and summarized the potential applications of different types of NPs in the many fields of dentistry.

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Phloretin loaded chitosan nanoparticles augments the pH-dependent mitochondrial-mediated intrinsic apoptosis in human oral cancer cells

Cited by 75 publications

References 46 publications

ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer

ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer

Betulin ameliorates 7,12‐dimethylbenz(a)anthracene‐induced rat mammary cancer by modulating MAPK and AhR/Nrf‐2 signaling pathway

Nanoparticles in Dentistry: A Comprehensive Review

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