Phlomoides umbrosa (Turcz.) Kamelin &amp; Makhm: A review of its traditional uses, botany, phytochemistry, pharmacology and clinical research

Li, Hang; Liu, Qiansong; Zhou, Xuehong; Fu, Xueyan

doi:10.1016/j.jep.2021.114252

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…In previous reports, P. umbrosa was found to possess various properties, including anti-allergic, anti-inflammatory, and anti-nociceptive effects [52]. These effects are likely attributed to the presence of various active compounds, such as sesamoside, shanzhiside methyl ester, chlorogenic acid, and barlerin [53]. When administered orally at doses of 100 and 300 mg/kg for 10 consecutive days, P. umbrosa root 70% ethanol extracts markedly increased longitudinal bone growth within the proximal tibial growth plate in adolescent SD female rats (5-weeks-old), consistent with findings showing a significant increase in the number of BrdU-labeled chondrocytes in the P. umbrosa groups at doses of 100 and 300 mg/kg.…”

Section: Phlomis Umbrosamentioning

confidence: 98%

The Effects of Natural Product-Derived Extracts for Longitudinal Bone Growth: An Overview of In Vivo Experiments

Lim,

Lee

2023

IJMS

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Approximately 80% of children with short stature are classified as having Idiopathic Short Stature (ISS). While growth hormone (GH) treatment received FDA approval in the United States in 2003, its long-term impact on final height remains debated. Other treatments, like aromatase inhibitors, metformin, and insulin-like growth factor-1 (IGF-1), have been explored, but there is no established standard treatment for ISS. In South Korea and other Asian countries, East Asian Traditional Medicine (EATM) is sometimes employed by parents to potentially enhance their children’s height growth, often involving herbal medicines. One such product, Astragalus membranaceus extract mixture HT042, claims to promote height growth in children and has gained approval from the Korean Food and Drug Administration (KFDA). Research suggests that HT042 supplementation can increase height growth in children without skeletal maturation, possibly by elevating serum IGF-1 and IGF-binding protein-3 levels. Preclinical studies also indicate the potential benefits of natural products, including of EATM therapies for ISS. The purpose of this review is to offer an overview of bone growth factors related to ISS and to investigate the potential of natural products, including herbal preparations, as alternative treatments for managing ISS symptoms, based on their known efficacy in in vivo studies.

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Section: Phlomis Umbrosamentioning

confidence: 98%

The Effects of Natural Product-Derived Extracts for Longitudinal Bone Growth: An Overview of In Vivo Experiments

Lim,

Lee

2023

IJMS

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Chemical constituents, anti-inflammatory and analgesic activities of iridoids preparation from Phlomoides labiosa bunge

Usmanov

Azamatov

Baykuziyev

et al. 2022

Natural Product Research

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An analysis method was developed for the separation and quantification of hesperidin, neohesperidin, neohesperidin dihydrochalcone and hesperetin by using HPLC-UV. Single factor experiments and Box-Behnken Designs were used to optimize separation of four flavonoids, in which a gradient elution method was adopted with 99% acetonitrile and 0.1% formic acid as mobile phases at a flow rate of 0.9 mL/min. A C18 column was used with a column temperature of 35℃. LODs and LOQs were below 0.84 µg/mL and 2.84 µg/mL, respectively. Linearity with good correlation coefficients (r>0.99, n=5) was attained, recovery rate of four flavonoids ranged from 88% to 130%, the RSD indicating results precision for analyzing hesperidin, neohesperidin, neohesperidin dihydrochalcone and hesperetin ranged from 1.2% to 4.6%. Finally, the 2 present method could be successfully applied to identify and quantify hesperidin, neohesperidin and hesperetin in Fructus Aurantii Immaturus and Pericarpium Citri Reticulatae.

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Phlomoides umbrosa (Turcz.) Kamelin & Makhm: A review of its traditional uses, botany, phytochemistry, pharmacology and clinical research

Cited by 2 publications

References 38 publications

The Effects of Natural Product-Derived Extracts for Longitudinal Bone Growth: An Overview of In Vivo Experiments

The Effects of Natural Product-Derived Extracts for Longitudinal Bone Growth: An Overview of In Vivo Experiments

Chemical constituents, anti-inflammatory and analgesic activities of iridoids preparation from Phlomoides labiosa bunge

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