Phlegcarines A-C, three Lycopodium alkaloids from Phlegmariurus carinatus (Desv. ex Poir.) Ching

Obscurinin A, a unique Lycopodium alkaloid possessing an 8/6/6/6/5 pentacyclic system isolated from Lycopodium obscurum L.

“…Fortunately, the single crystal was successfully obtained in methanol solvent at room temperature, which enabled the single-crystal X-ray diffraction analysis (Cu Kα) to confirm the planar structure and the absolute configuration (Fig. 3) as 5R,7S,12S,13S,14S,15R with a Flack's parameter of 0.06 (6).…”

“…3,4 This discovery has encouraged scientists to explore more structural and bioactive Lycopodium alkaloids. [5][6][7][8][9] Up to now, more than 500 Lycopodium alkaloids have been reported worldwide. 1,2,[10][11][12] Meanwhile, these complex N-heterocyclic frameworks have also been challenging targets for synthesis 13,14 and biosynthesis 15,16 studies.…”

Lycocasine A, a Lycopodium Alkaloid from Lycopodiastrum casuarinoides and Its Acid-Sensing Ion Channel 1a Inhibitory Activity

“…Lycopodiastrum casuarinoides is a perennial evergreen herb traditionally used for rheumatism treatment [7]. L. casuarinoides produces Lycopodium alkaloids, the characteristic metabolites of the Lycopodiaceae family [8][9][10], known for their diverse structures and unique skeletons [9,[11][12][13][14]. Studies have indicated that L. casuarinoides is particularly rich in lycodine-type Lycopodium alkaloids [15][16][17][18][19][20], some exhibiting significant anti-cholinesterase [21,22], neuroprotective [23], and cytotoxic activities [21].…”

Lycopodium Alkaloids from Phlegmariurus carinatus with Cytotoxic and Neuroprotective Effects

“…[9,10] Previous phytochemical studies on P. Carinatus identified a series of LAs and serratene triterpenes. [11][12][13][14] Some of these compounds showed various degrees of cytotoxic, anti-AChE, and anti-Parkinson's disease activities. In our previous study, seventeen abietane diterpenoids were isolated from this species, and their neuroprotective and cytotoxic activities were discussed.…”

“…The whole plant of P. Carinatus has long been used as a folk medicine for treating swelling, rheumatism, and pain [9,10] . Previous phytochemical studies on P. Carinatus identified a series of LAs and serratene triterpenes [11–14] . Some of these compounds showed various degrees of cytotoxic, anti‐AChE, and anti‐Parkinson's disease activities.…”