Phlebotomy resulting in controlled hypovolemia to prevent blood loss in major hepatic resections (PRICE-1): A feasibility randomized controlled trial

The safety and efficacy of hypovolemic phlebotomy on blood loss and transfusion in liver surgery: a systematic review and meta-analysis

“…Thirty-nine articles were advanced to full text review, of which 8 met inclusion criteria. [11][12][13][21][22][23][24][25] Three studies were randomized control trials (RCT), 11,22,24 4 were retrospective cohort studies 12,21,23,25 and 1 was a case series. 13 Study characteristics are summarized in Table 1.…”

“…Included papers were published between 2006 and 2019 and involved 2255 patients, of which 57% underwent HP. [11][12][13][21][22][23][24][25] There were 1409 (63%) male participants with a weighted mean age of 55 years (6 studies). [11][12][13]21,23,24 One of the papers was published in Mandarin 22 while the remainder were in English.…”

“…[11][12][13][21][22][23][24][25] There were 1409 (63%) male participants with a weighted mean age of 55 years (6 studies). [11][12][13]21,23,24 One of the papers was published in Mandarin 22 while the remainder were in English. [11][12][13]21,[23][24][25] Two of the included studies were conference abstracts, 24,25 for which the full text manuscripts have not yet been published.…”

“…[11][12][13]21,23,24 One of the papers was published in Mandarin 22 while the remainder were in English. [11][12][13]21,[23][24][25] Two of the included studies were conference abstracts, 24,25 for which the full text manuscripts have not yet been published. Surgery indications included colorectal cancer liver metastases, hepatocellular carcinoma, cholangiocarcinoma, gall bladder cancers, primary liver malignancies, benign pathologies, as well as orthotopic liver transplantation and liver resection for living donor procurement.…”

“…Surgery indications included colorectal cancer liver metastases, hepatocellular carcinoma, cholangiocarcinoma, gall bladder cancers, primary liver malignancies, benign pathologies, as well as orthotopic liver transplantation and liver resection for living donor procurement. [11][12][13][21][22][23][24][25] Definition and description of intervention The nomenclature used to describe HP varied across studies (Table 1). Terms utilized included "hypovolemic phlebotomy," "acute hemodilution with low CVP," "ANH with controlled hypovolemia," "Intraoperative blood salvage," and "phlebotomy.…”