Phlebography as the Gold Standard in Thromboprophylactic Studies?

Wille-Jørgensen, P.; Borris, L.; Jørgensen, L. N.; Hauch, O.; Lassen, M. R.; Nehen, A. M.; Kjær, L.; Jensen, R.

doi:10.3109/02841859209173121

Cited by 5 publications

(3 citation statements)

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“…Moreover, a bilateral venography is necessary for complete information. The evaluation of venograms proves to be a factor of uncertainty since the agreements on positive diagnosis among different investigators can vary between 65% and 83% [16]. New non-invasive and accurate methods have been developed over the past two decades [17].…”

Section: Discussionmentioning

confidence: 99%

Prevention of deep vein thrombosis in patients with hip fractures: Low molecular weight heparin versus dextran

et al. 1992

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A randomized open trial was undertaken to compare the antithrombotic efficacy of a low molecular weight heparin (LMWH; Sandoparin) with that of dextran 70 in patients undergoing surgery for hip fracture. One hundred thirteen patients received LMWH once daily subcutaneously at a fixed dosage while 103 patients received intravenous dextran 70. Postoperative deep vein thrombosis (DVT) was assessed by a diagnostic algorithm using the 125Iodine fibrinogen uptake test as screening and Duplex ultrasonography and/or ascending venography as confirming techniques for suspected DVT. The frequency of DVT was significantly lower in the LMWH group than in the dextran group (15.5 versus 32.6%, p less than 0.005). Proximal DVT was rare in both groups (LMWH: 2%, Dextran: 1%). Only one case of fatal fat pulmonary embolism was observed during the 10 day prophylaxis period in a patient receiving Dextran. Three cases of pulmonary embolism occurred later; one fatal event in the dextran group on day 14, and two cases in the LMWH group (one fatal and one non-fatal event) on day 14 and 17, respectively. There was no major bleeding complication in either group. We conclude that the LMWH we used is safe, was well tolerated, and has a significantly better thromboprophylactic effect than dextran 70.

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Section: Discussionmentioning

confidence: 99%

Prevention of deep vein thrombosis in patients with hip fractures: Low molecular weight heparin versus dextran

et al. 1992

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“…71 These factors can also lead to significant discrepancies in diagnosis, even among experienced radiologists. 71 These factors can also lead to significant discrepancies in diagnosis, even among experienced radiologists.…”

Section: Limitations and Pitfallsmentioning

confidence: 99%

Deep Vein Thrombosis and Its Diagnosis

Saeed¹

2004

Techniques in Orthopaedics

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“…There is no absolute method to confirm the accuracy of venography and therefore kappa analysis of interobserver and intraobserver reproducibility is used. The diagnosis of venographic DVT is only modestly reproducible [16][17][18] and this interobserver variability influences the reliability of meta-analyses based on venographic data.…”

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confidence: 99%