PHLDA1 (Pleckstrin Homology-Like Domain, Family A, Member 1)

Abstract

Short communication on PHLDA1, with data on DNA/RNA, on the protein encoded and where the gene is implicated. IdentityOther names: DT1P1B11, PHRIP, TDAG51 HGNC (Hugo): PHLDA1 Location: 12q21.2 Local order: Minus strand. DNA/RNA Description PseudogeneNot identified. Protein DescriptionThe PHLDA1 gene encodes for a 401 amino acid protein that is a member of the evolutionarily conserved pleckstrin homology-like domain family. PHLDA1 protein has a modular structure containing a central pleckstrin homology-like domain (PHL) and prolin-glutamine (PQ) and proline-histidine (PH) repeats in the C-terminal region (see figure above). ExpressionPHLDA1 is widely expressed in mammalian tissues displaying cytoplasmic, vesicle membrane, plasma membrane and nuclear subcellular localization. PHLDA1 expression is up-regulated by estrogen, IGF-1 (insulin-like growth factor 1), FGF (fibroblast growth factor), TPA (phorbol ester), and ER (endoplamic reticulum)-stress agents such as homocysteine, tunicamicyne, and farnesol. LocalisationCytoplasm, vesicle membrane, plasma membrane, nucleus. FunctionProtein binding. Several evidences have implicate PHLDA1 as a potential transcriptional activator that acts as a pro-apoptotic and antiproliferative factor, however the mechanisms by which PHLDA1 mediates cell survival is still under investigation. HomologyPHLDA2 (pleckstrin homology-like domain, family A, member 2) and PHLDA3 (pleckstrin homologylike domain, family A, member 3) are paralogs for PHLDA1.