2005
DOI: 10.1021/tx0501031
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PhIP Carcinogenicity in Breast Cancer:  Computational and Experimental Evidence for Competitive Interactions with Human Estrogen Receptor

Abstract: Many carcinogens have been shown to cause tissue specific tumors in animal models. The mechanism for this specificity has not been fully elucidated and is usually attributed to differences in organ metabolism. For heterocyclic amines, potent carcinogens that are formed in well-done meat, the ability to either bind to the estrogen receptor and activate or inhibit an estrogenic response will have a major impact on carcinogenicity. Here, we describe our work with the human estrogen receptor alpha (ERalpha), the m… Show more

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Cited by 31 publications
(28 citation statements)
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“…We have previously reported the powerful E 2 -like activity of the cooked meat-derived carcinogen PhIP (16), which was subsequently confirmed by others (30). We showed that PhIP binding to ERa leads to transcriptional activation of E 2 -responsive genes.…”
Section: Discussionsupporting
confidence: 67%
“…We have previously reported the powerful E 2 -like activity of the cooked meat-derived carcinogen PhIP (16), which was subsequently confirmed by others (30). We showed that PhIP binding to ERa leads to transcriptional activation of E 2 -responsive genes.…”
Section: Discussionsupporting
confidence: 67%
“…À10 mol/L), PhIP is able to stimulate proliferation in estrogen receptor-positive human mammary carcinoma MCF-7 cells in a manner that is inhibited by the antiestrogen ICI 182,780 (19,51,52). More recently, Nakai et al (53) reported that whereas PhIP treatment of Big Blue rats resulted in increased mutation frequencies in all lobes of the prostate, increased proliferation was only observed in the ventral lobe, the area where PhIP specifically induces prostate cancer.…”
mentioning
confidence: 99%
“…This association was even more pronounced among never smokers than among smokers (Bennion et al 2005;Grover et al 1980;Lam et al 2009). …”
Section: Cigarette Smokementioning
confidence: 88%