2022
DOI: 10.1038/s41419-022-04940-4
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PHF13 epigenetically activates TGFβ driven epithelial to mesenchymal transition

Abstract: Epigenetic alteration is a pivotal factor in tumor metastasis. PHD finger protein 13 (PHF13) is a recently identified epigenetic reader of H3K4me2/3 that functions as a transcriptional co-regulator. In this study, we demonstrate that PHF13 is required for pancreatic-cancer-cell growth and metastasis. Integrative analysis of transcriptome and epigenetic profiles provide further mechanistic insights into the epigenetic regulation of genes associated with cell metastasis during the epithelial-to-mesenchymal trans… Show more

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Cited by 4 publications
(3 citation statements)
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“…During development, the expression of EMT genes have been shown to be regulated via both histone modifications and the local enhancer-promoter looping 55 . Similar regulatory mechanisms to the EMT genes have also been shown to exist in cancer cells 51 , 52 , 56 , 57 . The 3D genome hierarchical orders, together with histone modifications and local DNA looping, establishes the architectural backbone of the genome in response to any functional ques during EMT or cell fate determination during development and in cancer cells 53 , 58 .…”
Section: Reconstructing the 3d Genome In Emt Modelsmentioning
confidence: 64%
“…During development, the expression of EMT genes have been shown to be regulated via both histone modifications and the local enhancer-promoter looping 55 . Similar regulatory mechanisms to the EMT genes have also been shown to exist in cancer cells 51 , 52 , 56 , 57 . The 3D genome hierarchical orders, together with histone modifications and local DNA looping, establishes the architectural backbone of the genome in response to any functional ques during EMT or cell fate determination during development and in cancer cells 53 , 58 .…”
Section: Reconstructing the 3d Genome In Emt Modelsmentioning
confidence: 64%
“…FGF13 has been found to play a role in cancer progression and treatment resistance. It has been shown to be associated with tumor growth and metastasis in pancreatic cancer (56). In human pluripotent stem cells, disrupting TJP1 leads to the activation of bone morphogenic protein-4 (BMP4) signaling and loss of patterning phenotype (57).…”
Section: Discussionmentioning
confidence: 99%
“…Alterations in activating H3K4me3 marks (or the epigenetic enzymes) are tightly related to PDAC metastasis. For instance, PHD finger protein 13 (PHF13) induces increased deposition of the activating epigenetic marks H3K4me3 on genes critical to pancreatic cancer cell migration and invasion [ 68 ]. Hypoxia causes inactivation of lysine demethylase 5A (KDM5A), increasing the H3K4me3 level and regulating the expression of EMT-associated genes [ 43 ].…”
Section: Discussionmentioning
confidence: 99%