Pheromones of Marine Invertebrates and Algae

Kita, Masakazu; Kikuchi, Makoto; Uemura, Daisuke

doi:10.1016/b978-008045382-8.00097-6

Cited by 3 publications

(1 citation statement)

References 140 publications

(86 reference statements)

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“…6,10,11 Sea anemone neurotoxins are polypeptides with molecular weights ranging from 3,000 to 6,500 Da, and previous reports support their capacity to block K + and Na + channels. 6,[12][13][14][15][16][17] The neurotoxins ShK and BgK, derived from Stichodactyla helianthus and Bunodosoma granulifera, respectively, act on more than six binding sites of the Kv1.3 channel. 18 It is important to note that the study of the conformational properties could provide an opportunity to deduce the structural determinants of each mode of action.…”

Section: Bioinformatics and Biology Insights Introductionmentioning

confidence: 99%

Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel

Sabogal-Arango

Barreto

Ramírez-Sánchez

et al. 2014

Bioinform Biol Insights

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Sea anemone neurotoxins are peptides that interact with Na+ and K+ channels, resulting in specific alterations on their functions. Some of these neurotoxins (1ROO, 1BGK, 2K9E, 1BEI) are important for the treatment of about 80 autoimmune disorders because of their specificity for Kv1.3 channel. The aim of this study was to identify the common residues among these neurotoxins by computational methods, and establish whether there is a pattern useful for the future generation of a treatment for autoimmune diseases. Our results showed eight new key common residues between the studied neurotoxins interacting with a histidine ring and the selectivity filter of the receptor, thus showing a possible pattern of interaction. This knowledge may serve as an input for the design of more promising drugs for autoimmune treatments.

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Section: Bioinformatics and Biology Insights Introductionmentioning

confidence: 99%

Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel

Sabogal-Arango

Barreto

Ramírez-Sánchez

et al. 2014

Bioinform Biol Insights

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Chemical Ecology of Chemosensation in Asteroidea: Insights Towards Management Strategies of Pest Species

et al. 2018

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Within the Phylum Echinodermata, the class Asteroidea, commonly known as starfish and sea stars, encompasses a large number of benthos inhabiting genera and species with various feeding modalities including herbivores, carnivores, omnivores and detritivores. The Asteroidea rely on chemosensation throughout their life histories including hunting prey, avoiding or deterring predators, in the formation of spawning aggregations, synchronizing gamete release and targeting appropriate locations for larval settlement. The identities of many of the chemical stimuli that mediate these physiological and behavioural processes remain unresolved even though evidence indicates they play pivotal roles in the functionality of benthic communities. Aspects of chemosensation, as well as putative chemically-mediated behaviours and the molecular mechanisms of chemoreception, within the Asteroidea are reviewed here, with particular reference to the coral reef pest the Crown-of-Thorns starfish Acanthaster planci species complex, in the context of mitigation of population outbreaks.

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Parasite-Modified Chemical Communication: Implications for Aquatic Community Dynamics

Friesen

Detwiler

2021

Front. Ecol. Evol.

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Chemical communication within an aquatic environment creates an intricate signaling web that provides species with information about their surroundings. Signaling molecules, like oxylipins, mediate a multitude of interactions between free-living members of a community including non-consumptive effects by predators. Parasites are another source of signaling molecules in aquatic communities and contribute directly by synthesizing them or indirectly by manipulating host chemical cues. If chemical cues of infected hosts are altered, then non-consumptive interactions between other members of the community may also be affected. Different cues from infected hosts may alter behaviors in other individuals related to foraging, competition, and defense priming. Here, we discuss how parasites could modify host chemical cues, which may have far reaching consequences for other community members and the ecosystem. We discuss how the modification of signaling molecules by parasites may also represent a mechanism for parasite-modified behavior within some systems and provide a mechanism for non-consumptive effects of parasites. Further, we propose a host-parasite system that could be used to investigate some key, unanswered questions regarding the relationship between chemical cues, parasite-modified behavior, and non-consumptive effects. We explain how trematode-gastropod systems can be used to test whether there are alterations in the diversity and amounts of signaling molecules available, and if habitat use, immune function, and behavior of other individuals and species are affected. Finally, we argue that changes to pathway crosstalk by parasites within communities may have broad ecological implications.

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Pheromones of Marine Invertebrates and Algae

Cited by 3 publications

References 140 publications

Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel

Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel

Chemical Ecology of Chemosensation in Asteroidea: Insights Towards Management Strategies of Pest Species

Parasite-Modified Chemical Communication: Implications for Aquatic Community Dynamics

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