Pheromone Induces Programmed Cell Death in S. cerevisiae

Severin, Fedor F.; Hyman, Anthony A.

doi:10.1016/s0960-9822(02)00776-5

Cited by 208 publications

(203 citation statements)

References 15 publications

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“…Interaction of the pheromone with its receptor (Ste2p or Ste3p) results in activation of the MAP kinase-signaling cascade (which involves the key kinase Ste20p), subsequent increase of intracellular Ca 2 þ , and a rise in mitochondrial activity, followed by cytochrome c release and apoptosis. 12,36 In contrast, death caused by elevated concentrations of pheromone lacks certain hallmarks of apoptosis. 42 Of note, sporulation following meiosis of diploid cells is coupled to apoptosis as well.…”

Section: Triggering Yeast Apoptosismentioning

confidence: 99%

“…75 In addition, the kinase Ste20p has been shown to be necessary for pheromone-induced apoptosis in yeast. 12 Therefore, H2B epigenetics may constitute a functional link between replicative life-span control and the pheromone-associated MAPK cascade. 75 Mitochondrial factors: friends when in and foes when out.…”

Section: Proteins and Pathways Regulating Yeast Apoptosismentioning

confidence: 99%

“…During failed mating, mating-type pheromones trigger cell death to clean the culture from infertile or otherwise damaged haploid cells, thus guaranteeing the adaptive benefit of the diploid state, which allows meiotic recombination and the resulting genetic diversity. 12 However, apoptosis can also occur during meiosis of diploid cells, which might ensure that only genetic recombinants that are adapted to their surroundings survive. 13,14 Apoptosis resulting from these different physiological scenarios (Figure 2) ameliorates the long-term survival of the population and, consequently, increases the chances of spreading of the clone.…”

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Apoptosis in yeast: triggers, pathways, subroutines

et al. 2010

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A cell's decision to die is controlled by a sophisticated network whose deregulation contributes to the pathogenesis of multiple diseases including neoplastic and neurodegenerative disorders. The finding, more than a decade ago, that baker's yeast (Saccharomyces cerevisiae) can undergo apoptosis uncovered the possibility to investigate this mode of programmed cell death (PCD) in a model organism that combines both technical advantages and a eukaryotic 'cell room.' Since then, numerous exogenous and endogenous triggers have been found to induce yeast apoptosis and multiple yeast orthologs of crucial metazoan apoptotic regulators have been identified and characterized at the molecular level. Such apoptosis-relevant orthologs include proteases such as the yeast caspase as well as several mitochondrial and nuclear proteins that contribute to the execution of apoptosis in a caspase-independent manner. Additionally, physiological scenarios such as aging and failed mating have been discovered to trigger apoptosis in yeast, providing a teleological interpretation of PCD affecting a unicellular organism. Due to its methodological and logistic simplicity, yeast constitutes an ideal model organism that is efficiently helping to decipher the cell death regulatory network of higher organisms, including the switches between apoptotic, autophagic, and necrotic pathways of cellular catabolism. Here, we provide an overview of the current knowledge about the apoptotic subroutine of yeast PCD and its regulation.

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Section: Triggering Yeast Apoptosismentioning

confidence: 99%

Section: Proteins and Pathways Regulating Yeast Apoptosismentioning

confidence: 99%

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confidence: 99%

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Apoptosis in yeast: triggers, pathways, subroutines

et al. 2010

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“…1). While most of the upstream mechanisms remain still unknown, apoptosis induction by acetic acid, amiodarone, and α-factor has clearly been linked to hyperpolarisation of the mitochondrial membrane potential, reduction of cytochrome c oxidase (COX) activity, mitochondrial ROS formation, cytochrome c release, and eventually loss of mitochondrial membrane potential and cell death [13,[20][21][22].…”

Section: Drug-induced Cell Deathmentioning

confidence: 99%

“…Recent evidence suggests a regulated cross-talk between deacetylation and phosphorylation within Histone H2B tails required for apoptosis induction in yeast [9]. Physiological scenarios of yeast apoptosis have been demonstrated during ageing [10][11][12], the mating process [13], and development of yeast multicellular colonies [14]. Hence, a physiological finality for a unicellular suicide program has emerged (reviewed in Buttner et al [15]).…”

Section: Introductionmentioning

confidence: 99%

The mitochondrial pathway in yeast apoptosis

et al. 2007

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Mitochondria are not only important for the energetic status of the cell, but are also the fatal organelles deciding about cellular life and death. Complex mitochondrial features decisive for cell death execution in mammals are present and functional in yeast: AIF and cytochrome c release to the cytosol, mitochondrial fragmentation as well as mitochondrial hyperpolarisation followed by an oxidative burst, and breakdown of mitochondrial membrane potential. The easy accessibility of mitochondrial manipulations such as repression of respiration by growing yeast on glucose or deletion of mitochondrial DNA (rho 0 ) on the one hand and the unique ability of yeast cells to grow on nonfermentable carbon sources by switching on mitochondrial respiration on the other hand have made yeast an excellent tool to delineate the necessity for mitochondria in cell death execution. Yeast research indicates that the connection between mitochondria and apoptosis is intricate, as abrogation of mitochondrial function can be either deleterious or beneficial for the cell depending on the specific context of the death scenario. Surprisingly, mitochondrion dependent yeast apoptosis currently helps to understand the aetiology (or the complex biology) of lethal cytoskeletal alterations, ageing and neurodegeneration. For example, mutation of mitochondrial superoxide dismutase or CDC48/VCP mutations, both T. Eisenberg · S. Büttner · F. Madeo ( ) Institute of Molecular Biosciences, Universitaetsplatz 2, University of Graz, 8010 Graz, Austria e-mail: frank.madeo@uni-graz.at G. Kroemer Apoptosis, Cancer, and Immunity Unit, Institut Gustave Roussy, Faculté Paris Sud-Université, Institut National de la Santé et de la Recherche Médicale, Paris XI, France implicated in several neurodegenerative disorders, are associated with mitochondrial impairment and apoptosis in yeast.

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Phenoptosis: Programmed Death of an Organism

2018

Apoptosis and Beyond

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Pheromone Induces Programmed Cell Death in S. cerevisiae

Cited by 208 publications

References 15 publications

Apoptosis in yeast: triggers, pathways, subroutines

Apoptosis in yeast: triggers, pathways, subroutines

The mitochondrial pathway in yeast apoptosis

Phenoptosis: Programmed Death of an Organism

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