Pheophorbide a , a compound isolated from the leaves of Arrabidaea chica , induces photodynamic inactivation of Trypanosoma cruzi

Miranda, Nathielle; Gerola, Adriana P.; Novello, Cláudio Roberto; Ueda-Nakamura, Tânia; Silva, Sueli de Oliveira; Dias-Filho, Benedito Prado; Hioka, Noboru; Mello, João Carlos Palazzo de

doi:10.1016/j.pdpdt.2017.05.004

Cited by 32 publications

(17 citation statements)

References 45 publications

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“…PhA is a known product of chlorophyll breakdown, with the chemical formula C 35 H 36 N 4 O 5 and a molecular weight of 592.70. The IUPAC chemical name of PhA is [3S,4S]‐9‐ethenyl‐14‐ethyl‐21‐[methoxycarbonyl]‐4,8,13,18‐tetramethyl‐20‐oxo‐3‐phorbinepropanoic acid; it contains a hydroxyl group in the chemical structure (Miranda et al, ). It was reported that the hydroxyl group in the chemical structure might bind to the allosteric or active site of the enzyme and inhibit the activity of the enzyme (Ali et al, ; Stern, Hagerman, Steinberg, & Mason, ).…”

Section: Discussionmentioning

confidence: 99%

“…In particular, at 50 μM, PhA exerted stronger inhibitory effects on α-amylase than 100-μM acarbose. PhA is a known product of chlorophyll breakdown, with the chemical formula 4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid; it contains a hydroxyl group in the chemical structure (Miranda et al, 2017). It was reported that the hydroxyl group in the chemical structure might bind to the allosteric or active site of the enzyme and inhibit the activity of the enzyme (Ali et al, 2016;Stern, Hagerman, Steinberg, & Mason, 1996).…”

Section: Figure 4 Effect Of Pheophorbide a On Cell Viability In 3t3-l1mentioning

confidence: 99%

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Pheophorbide A from Gelidium amansii improves postprandial hyperglycemia in diabetic mice through α‐glucosidase inhibition

Kim

Han

2019

Phytotherapy Research

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This study was designed to determine the inhibitory effects of pheophorbide A on carbohydrate digesting enzymes and its ability to improve postprandial hyperglycemia in streptozotocin (STZ)‐induced diabetic mice. Pheophorbide A caused noticeable inhibitory effects on α‐glucosidase and α‐amylase, with half‐maximal inhibitory concentrations (IC50) of 80.65 ± 5.90 and 76.48 ± 6.31 μM, respectively. The pheophorbide‐mediated inhibition of α‐glucosidase and α‐amylase was significantly more effective than that of the positive control, acarbose. The increase in postprandial blood glucose levels was more significantly suppressed in the pheophorbide A group than in the control group of STZ‐induced diabetic mice. In addition, the area under the curve was decreased by pheophorbide A intake in STZ‐induced diabetic mice. Our results suggested that pheophorbide A may help to improve postprandial hyperglycemia by inhibiting the activity of carbohydrate digesting enzymes.

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Section: Discussionmentioning

confidence: 99%

Section: Figure 4 Effect Of Pheophorbide a On Cell Viability In 3t3-l1mentioning

confidence: 99%

Pheophorbide A from Gelidium amansii improves postprandial hyperglycemia in diabetic mice through α‐glucosidase inhibition

Kim

Han

2019

Phytotherapy Research

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“…The parasitic euglenoid Trypanosoma cruzi causes Chagas disease [ 49 ]. This disease can be transferred to humans by triatomine bugs and sometimes orally.…”

Section: Apdt Targeting Diseases and Organismsmentioning

confidence: 99%

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

Polat

Kang

2021

Biomedicines

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Health problems and reduced treatment effectiveness due to antimicrobial resistance have become important global problems and are important factors that negatively affect life expectancy. Antimicrobial photodynamic therapy (APDT) is constantly evolving and can minimize this antimicrobial resistance problem. Reactive oxygen species produced when nontoxic photosensitizers are exposed to light are the main functional components of APDT responsible for microbial destruction; therefore, APDT has a broad spectrum of target pathogens, such as bacteria, fungi, and viruses. Various photosensitizers, including natural extracts, compounds, and their synthetic derivatives, are being investigated. The main limitations, such as weak antimicrobial activity against Gram-negative bacteria, solubility, specificity, and cost, encourage the exploration of new photosensitizer candidates. Many additional methods, such as cell surface engineering, cotreatment with membrane-damaging agents, nanotechnology, computational simulation, and sonodynamic therapy, are also being investigated to develop novel APDT methods with improved properties. In this review, we summarize APDT research, focusing on natural photosensitizers used in in vitro and in vivo experimental models. In addition, we describe the limitations observed for natural photosensitizers and the methods developed to counter those limitations with emerging technologies.

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“…Bignonia species exhibited various biological activities including; cytotoxic [54] antiprotozoal [51], analgesic [55], insect repellant [15], anti-inflammatory [37] and cholinergic activities [43] as demonstrated in (Table 3).…”

Section: Biological Activities Of Genus "Bignonia"mentioning

confidence: 99%

Phytochemical and biological overview of genus "Bignonia" (1969-2018)

Mahmoud

Hamed

Samy

et al. 2019

Journal of advanced Biomedical and Pharmaceutical Sciences

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Bignonia L. is the fifth largest genus in the tribe Bignonieae, with 31 lianas species. Bignonia plants are widely used in traditional medicine as skin ailments like fungal infections, postpartum haemorrhage, malaria, diabetes and pneumonia. Many literature reported that Bignonia species contained different classes of active constituents as phenylethanoids, phenolics, lignans, flavonoids, coumarins and xanthones. Additionally, they demonstrated a wide range of biological activities as cytotoxic, wound healing, antidiabetic, sleep induction, gastroprotection, anti-obesity and insecticidal activities. This review revealed that only 15 species have been reported in the literature. Moreover, Bignonia plants need further studies as they are considered a good source for bioactive natural products.

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Pheophorbide a , a compound isolated from the leaves of Arrabidaea chica , induces photodynamic inactivation of Trypanosoma cruzi

Cited by 32 publications

References 45 publications

Pheophorbide A from Gelidium amansii improves postprandial hyperglycemia in diabetic mice through α‐glucosidase inhibition

Pheophorbide A from Gelidium amansii improves postprandial hyperglycemia in diabetic mice through α‐glucosidase inhibition

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

Phytochemical and biological overview of genus "Bignonia" (1969-2018)

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