Pheochrontocytoma: A rare cause of impairment of metabolic control in diabetes

Insulin-Requiring Diabetes mellitus, Hyperlipidemia, and Anginal Chest Pains as Prominent Features of Pheochromocytoma

“…Furthermore, in a large review of 60 patients with the diagnosis of pheochromocytoma, 24% were found to have diabetes mellitus as defined by fasting glu cose levels >7.0 mmol/1 [5]. There are also several case reports of frank diabetes in association with pheochromo cytoma, however, in only 1 case the course was compli cated with ketoacidosis [6][7][8][9][10]. The glucose intolerance in these patients has been attributed to catecholamineinduced suppression of insulin release which could be reversed by pharmacologic blockade of alpha-adrenergic receptors and remit with removal of the tumor, as well as catecholamine-induced glycogenolysis and peripheral re sistance to insulin action [10,11].…”