Pheochromocytoma Presenting as Acute Severe Congestive Heart Failure, Dilated Cardiomyopathy, and Severe Mitral Valvular Regurgitation: A Case Report and Review of the Literature

Kelley, Scott R.; Goel, Tarun K.; Smith, James M.

doi:10.1016/j.jsurg.2008.11.004

Cited by 6 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our patient had global hypokinesis that has rarely been observed in patients with pheochromocytoma 11 12. Autopsy findings in patients with pheochromocytoma and cardiomyopathy demonstrate multifocal myocarditis and replacement fibrosis with mixed inflammatory cells and contraction band necrosis 4 13 14. The interstitial mononuclear inflammation seen on autopsy is distinct from the polymononuclear inflammation seen in ischaemic cardiomyopathy.…”

Section: Discussionmentioning

confidence: 58%

“…The majority of cases of heart failure in patients with pheochromocytomas demonstrate a stress-induced cardiomyopathy called Takotsubo cardiomyopathy or broken-heart syndrome 4 9–11. In these patients echocardiograms demonstrate transient left ventricular apical ballooning with midventricular dyskinesis that extends beyond the distribution of any single coronary artery 9 11.…”

Section: Discussionmentioning

confidence: 99%

“…This was then changed to carvedilol and phenoxybenzamine as per current recommendations 4. She was slowly hydrated with intravenous fluids.…”

Section: Treatmentmentioning

confidence: 99%

See 2 more Smart Citations

Pheochromocytoma presenting as acute decompensated heart failure reversed with medical therapy

Mulla

Marik²

2012

BMJ Case Reports

View full text Add to dashboard Cite

A 26-year-old woman presented to hospital with acute chest pain, hypertension, tachycardia and an elevated serum creatinine. She developed respiratory distress requiring endotracheal intubation and mechanical ventilation. She progressed to multiorgan failure due to decompensated congestive heart failure. Echocardiography demonstrated global hypokinesis and an ejection fraction of <10%. Her cardiac function improved with fluid resuscitation and β blockade, and she was eventually discharged home. She was readmitted a few days later with pancreatitis after presenting with nausea, abdominal pain and hypertension. During hospitalisation she had paroxysms of headache, nausea and diaphoresis associated with hypertension and tachycardia. A CT scan of her abdomen revealed an adrenal mass and serum metanephrine studies confirmed the diagnosis of pheochromocytoma. After fluid resuscitation and sympathetic blockade her ejection fraction improved to 55%. The patient underwent an uneventful adrenalectomy and made a complete recovery.

show abstract

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pheochromocytoma presenting as acute decompensated heart failure reversed with medical therapy

Mulla

Marik²

2012

BMJ Case Reports

View full text Add to dashboard Cite

show abstract

“…The prevalence of pheochromocytoma in the general population is estimated to be 0.3–1.9% 12 13. Its diverse manifestations can make the diagnosis difficult, especially when classic symptoms are absent 14…”

Section: Discussionmentioning

confidence: 99%

Transient cardiogenic shock during a crisis of pheochromocytoma triggered by high-dose exogenous corticosteroids

et al. 2015

View full text Add to dashboard Cite

SUMMARYWe report a case of a 39-year-old woman who presented to the emergency department (ED) with symptoms of pharyngitis and fever. Diagnosed with streptococcal pharyngitis, she received antibiotics and dexamethasone, and was discharged. Within 24 h she returned to the ED with signs and symptoms of an acute coronary syndrome; she was thus given β-blockers. Her coronary angiogram was normal. She developed cardiogenic shock with an ejection fraction (EF) of 10% and apical ballooning on echocardiography. Her condition improved with optimal medical therapy. Subsequent testing weeks later confirmed the presence of a pheochromocytoma. Following prazosin and an adrenalectomy, all her antihypertensive medications were weaned and her EF normalised. We believe the high-dose exogenous corticosteroids triggered a pheochromocytoma crisis. The concomitant use of β-blockers without preceding α blockade resulted in cardiovascular collapse. Pheochromocytoma crisis must be included in the differential diagnosis of any dramatic haemodynamic collapse after administration of exogenous corticosteroid or β-blockers. BACKGROUND

show abstract

“…The hypoxic state stimulates catecholamine secretion from the adrenal medulla, and chronic endocrine hyperreactivity may lead to hyperplasia and neoplasia [9]. Several cases have reported the association of pheochromocystoma and heart disease [10]. …”

Section: Discussionmentioning

confidence: 99%

Extra-adrenal pheochromocytoma after operation of congenital heart disease: a case report of 18-year-old boy

et al. 2012

View full text Add to dashboard Cite

Extra-adrenal pheochromocytoma is rare and presents variable symptoms. Its difficulty to diagnosis delays appropriate treatment. We would like to report an unusual case of extra-adrenal pheochromocytoma. The patient came to the emergency room with dyspnea, palpitation, and cyanosis. He had a history of hospitalization for Fontan operation due to congenital heart disease. Despite medication, his blood pressure remained high. After additional laboratory and image exams, he was diagnosed with extra-adrenal pheochromocytoma and had surgical treatment. The final pathology report was extra-adrenal pheochromocytoma with high risk of malignancy. The postoperative course was uneventful and showed normal laboratory results even after 3 months of outpatient follow-up. Extra-adrenal pheochromocytoma presents variable symptoms. We should consider endocrinologic diseases like extra-adrenal pheochromocytoma in cases presenting with palpitation and high blood pressure, even with a past history of cardiac surgery.

show abstract

Pheochromocytoma Presenting as Acute Severe Congestive Heart Failure, Dilated Cardiomyopathy, and Severe Mitral Valvular Regurgitation: A Case Report and Review of the Literature

Cited by 6 publications

References 30 publications

Pheochromocytoma presenting as acute decompensated heart failure reversed with medical therapy

Pheochromocytoma presenting as acute decompensated heart failure reversed with medical therapy

Transient cardiogenic shock during a crisis of pheochromocytoma triggered by high-dose exogenous corticosteroids

Extra-adrenal pheochromocytoma after operation of congenital heart disease: a case report of 18-year-old boy

Contact Info

Product

Resources

About