Pheochromocytoma associated with adrenocortical adenoma: Case report and literature review.

Inoue, Junnosuke; Oishi, Seiichi; Naomi, Syojiro; Umeda, Teruhisa; Satô, Tatsuo

doi:10.1507/endocrj1954.33.67

Cited by 32 publications

(14 citation statements)

References 14 publications

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“…[1][2][3][4] Our case differs substantially from others reported in the literature, in as much as bilateral adrenal mass were detected incidentally on imaging studies, in a patient with very few symptoms or findings typical of secreting pheochromocytoma or hyperaldosteronism. In fact, only transient hypokalemia and gradual development of resistant hypertension oriented us towards an endocrine hypertensive disorder.…”

Section: Discussionmentioning

confidence: 57%

“…[1][2][3][4] In such cases, the diagnostic pathway is often very challenging requiring a strict multidisciplinary cooperation and advanced lab and radiological tests and techniques. We present a case of pheochromocytoma and aldosterone-producing adenoma in the same adrenal gland, which were found incidentally and were documented by biochemical studies and pathological examination.…”

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confidence: 99%

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Incidentally discovered pheochromocytoma and aldosterone-producing adenoma in the same adrenal gland

Negro¹,

Santi²,

Giunta³

et al. 2015

Ital J Med

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The simultaneous occurrence of pheochromocytoma and aldosterone-producing adrenal cortical adenoma is extremely rare. [1][2][3][4] In such cases, the diagnostic pathway is often very challenging requiring a strict multidisciplinary cooperation and advanced lab and radiological tests and techniques. We present a case of pheochromocytoma and aldosterone-producing adenoma in the same adrenal gland, which were found incidentally and were documented by biochemical studies and pathological examination. Case ReportA 65-year-old female was referred for the evaluation of bilateral adrenal masses, which had been found incidentally at abdominal ultrasonography performed for a clinical suspicion of gallbladder stones, and subsequently studied with magnetic resonance imaging at another institution (imaging unavailable).She had been diagnosed with grade 2 hypertension at age 40, and her blood pressure values had become progressively resistant to antihypertensive therapy (ramipril 10 mg/day, amlodipine 10 mg/day and doxazosin 8 mg/day) in the last four years. During this period, routine blood chemistries revealed sporadically only mild hypokalemia (3 to 3.5 m/Eq/L) with normal renal function and blood glucose values. Therefore, spironolactone 50 mg/day was added to her drug therapy by general practitioner, with improvement in the control of her blood pressure values. She had family history of hypertension and coronary artery disease (both parents); neoplasms were not reported in any family members. Her past medical history included intolerance to statins prescribed for familial hypercholesterolemia. In the last five months, the patient had been complaining of epigastric and right flank pain besides mild anxiety and weakness; she denied palpitations, pallor, headache, sweating, tremor, leg cramps or polyuria. At physical examination, blood pressure was 162/94 mmHg and the heart rate was 78 bpm and no orthostatic pressure gradient was detected. She was still on treatment with ramipril, amlodipine, doxazosin and spironolactone. Blood cell count was within normal limits. Serum sodium was 143 mEq/L, potassium 3.7 mEq/L, chloride 101 mEq/L and bicarbonate 27.3Incidentally discovered pheochromocytoma and aldosterone-producing adenoma in the same adrenal gland ABSTRACTSimultaneous occurrence of pheochromocytoma and aldosterone-producing adrenocortical tumor has been rarely reported in patients with symptoms or findings suggestive for both neoplasms. Herein, we report and discuss on a challenging case of synchronous pheochromocytoma and aldosterone-producing adenoma incidentally detected in the same adrenal gland and documented by biochemical studies and pathological examination.

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Section: Discussionmentioning

confidence: 57%

mentioning

confidence: 99%

Incidentally discovered pheochromocytoma and aldosterone-producing adenoma in the same adrenal gland

Negro¹,

Santi²,

Giunta³

et al. 2015

Ital J Med

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“…One of the other cases included a para-aortic pheochromocytoma; in the others, the two tumors were found in the same adrenal gland. Most reported simultaneous pheochromocytomas and adrenocortical adenomas [4] as well as corticomedullary mixed tumors of the adrenal gland [5] arose in the context of the ectopic ACTH syndrome. The simultaneous occurrence of pheochromocytoma and aldosterone-producing adenoma has been considered coincidental.…”

Section: Discussionmentioning

confidence: 99%

Hypertension Due to Coexisting Pheochromocytoma and Aldosterone-Producing Adrenal Cortical Adenoma

Miyazawa¹,

Kigoshi

Nakano

et al. 1998

Am J Nephrol

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A 49-year-old male was diagnosed as having primary aldosteronism at age 39, and he was treated with antihypertensive drugs. In 1995, a computed tomogram revealed a mass in the right adrenal gland. Radiological examinations and endocrinological data revealed the presence of a pheochromocytoma in the right and an adrenocortical tumor in the left adrenal gland. Right adrenalectomy and left partial adrenalectomy were performed. Histologically, the right adrenal mass was compatible with pheochromocytoma, and the left adrenal mass was an adrenocortical adenoma. Endocrinological data as well as blood pressure returned to normal after operation.

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“…Coexistence of adrenocortical adenoma and pheochromocytoma in the same gland is extremely rare. Only few cases have been reported in the English literature [1][2][3][4][5][6][7][8][9]. Herein, we report another case of adrenal collision tumor comprised of an adrenocortical adenoma and a pheochromocytoma in the same adrenal gland and emphasize the importance of conducting biochemical tests for pheochromocytoma before performing surgery to avoid intraoperative and postoperative complications of adrenal masses.…”

Section: Introductionmentioning

confidence: 91%

A Rare Case of Collision Tumor: Coexistence of Adrenocortical Adenoma and Pheochromocytoma in the Same Adrenal Gland

Abdullazade

2012

J Med Cases

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Simultaneous occurrence of both adrenocortical adenoma and pheochromocytoma in the same adrenal gland is extremely rare in the literature. We report a 38-year-old female who presented with palpitation, chest pain and tremor with a right adrenal mass consistent with adrenocortical adenoma on computed tomography. Both metanephrine and normetanephrine levels were high in the urine. The biochemical tests strongly suggested the diagnosis of pheochromocytoma. Pathological examination of the adrenalectomy specimen revealed a collision tumor composed of an adrenocortical adenoma and a pheochromocytoma. Although rare, the present case is noteworthy in highlighting the importance of conducting biochemical tests to rule out pheochromocytoma for any adrenal mass prior to surgery.

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Pheochromocytoma associated with adrenocortical adenoma: Case report and literature review.

Abstract: The case of a 60-year

Cited by 32 publications

References 14 publications

Incidentally discovered pheochromocytoma and aldosterone-producing adenoma in the same adrenal gland

Incidentally discovered pheochromocytoma and aldosterone-producing adenoma in the same adrenal gland

Hypertension Due to Coexisting Pheochromocytoma and Aldosterone-Producing Adrenal Cortical Adenoma

A Rare Case of Collision Tumor: Coexistence of Adrenocortical Adenoma and Pheochromocytoma in the Same Adrenal Gland

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