Pheochromocytoma and Essential Hypertensive Vascular Disease

Goldenberg, Marcel; Aranow, Henry; Smith, Alvy Ray; Faber, Mogens

doi:10.1001/archinte.1950.00230180028003

Cited by 97 publications

(20 citation statements)

References 14 publications

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“…As mentioned, isoproterenol has a power ful action on all p-receptors and almost no action on a-receptors [1][2][3][4][5]. Its main actions are on the heart, the smooth muscle of bron chi.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Adrenoceptor Agonists and Antagonists on Cardiovascular Functional Parameters in Rats

Young

Lin²,

Lin³

1992

Pharmacology

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The effects of intravenous administration of adrenoceptor agonists and antagonists on electrocardiographic or blood pressure (BP) functional parameters were assessed in urethane-anesthetized rats. The responses of cardiovascular functional parameters produced by these drugs included: (1) isoproterenol decreased the duration of a whole BP cycle (Wd), duration of the diastolic wave (Dd), peak amplitude of the systolic wave (SYa), amplitude of the diastolic notch (DNa), amplitude of the diastolic wave (DWa), pulse pressure (dp) and mean arterial pressure (mp) but increased the heart rate (HR) accompanied by prolonged R-R (RR) or P-P interval (PP) (2) propranolol decreased SYa, DNa, dp, mp, HR, the amplitude of the P wave (Pa) and amplitude of the S wave (Sa) but increased the duration of the QRS wave, P-R interval, duration of the R wave (Rd) and duration of the P wave (Pd); (3) adrenaline decreased HR (accompanied by prolonged RR and PP), Rd, Pa and amplitude of the T wave (Ta) but increased Pd, Wd, Dd, DNA, the time interval between aortic valve opening and closure (Dw), dp, mp, amplitude of the Q wave and amplitude of the R wave (Ra); (4) noradrenaline decreased HR (accompanied by prolonged RR and PP) and Pa but increased Wd, Pd, SYa, DNa, Dw, dp, mp, Ra and Ta; (5) phenylephrine decreased HR (accompanied by prolonged RR and PP) and Pa but increased Wd, Dd, DNa, mp and Ra; (6) phentolamine decreased SYa, DNa, DWa, Dw, dp and mp. This study illustrates the utility of the automated electrocardiogram (ECG) and BP analysis system for investigation of adrenoceptor agonists and antagonists. The use of this methodology not only reproduced most of cardiovascular functional parameter effects produced by these drugs using the conventional methodology but also realizes some new information about the drug-induced ECG or BP waveform effects.

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Section: Discussionmentioning

confidence: 99%

“…The actions of noradrenaline and adrena line have been extensively compared in vivo and in vitro [4][5][6][7][8][9]. Noradrenaline is a potent agonist at a-recepotrs and has little action on ßi-rcceptors; however, it is somewhat less po tent than adrenaline on the a-receptors of most organs.…”

Section: Discussionmentioning

confidence: 99%

Effects of Adrenoceptor Agonists and Antagonists on Cardiovascular Functional Parameters in Rats

Young

Lin²,

Lin³

1992

Pharmacology

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“…Performing mental work increases adrenaline output, whereas effects on noradrenaline are less marked and less consistent [7], Injection of ad renaline increases the heart rate whereas noradrenaline decreases it [8], Increase of heart rate may be due to either an increase of sympathetic ac tivity or a decrease of vagal tone. In our experiment, an indirect proof of adrenergic activity during the task was given by the blockage of the in crease of heart rate in the propranolol session.…”

Section: Discussionmentioning

confidence: 99%

Effect of Propranolol on Monosynaptic Reflex Activity during a Task

Brunia¹

1979

Stereotact Funct Neurosurg

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20 normal healthy subjects in a double-blind crossover experiment were given a tablet of either 40 mg propranolol or placebo half an hour before the beginning of the experiment. At rest and during the performance of a task, heart rate, Achilles tendon (T) and Hoffmann (H) reflexes were recorded. No increase in heart rate occurred during the task in the propranolol session. The increase of T-reflex amplitude, a common finding during the task under consideration, was larger in the propranolol session. No difference with H reflexes was found. It is concluded that the increase of T-reflex amplitudes during the task is caused only by fusimotor and not by sympathetic activity. It is speculated that if the sympathetic system plays a role at all, the effect on the T reflex is depressive rather than facilitating.

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“…1,2 The sequelae are predictable on the basis of continuous infusion of agonists that activate ␤ and ␣ adrenergic receptors (ARs). These monoamine agonists, however, are not the only means by which ␤-ARs can be activated.…”

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confidence: 99%