Phenytoin induces interleukin-1 production in vitro

Modéer, Thomas; Karsten, Johan; Weintraub, Andrej; Gidlund, Magnus; Kg, Sundqvist

doi:10.1016/0024-3205(89)90215-4

Cited by 15 publications

(2 citation statements)

References 17 publications

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“…In Seymour et al study [41], it has been shown that phenytoin is capable of influencing the cell cycle, and that phenytoin inhibits the process of Ca 2+ absorption in fibroblasts and also causes cell hyperplasia. Some researchers have expressed that rat gingival fibroblasts show resistance against phenytoin-induced overgrowth, probably because of their functional heterogeneity [42]. However, Pour Abbas et al, by investigating metabolic activity of proliferation in rat fibroblasts, have reached to contrary results [41].…”

Section: Discussionmentioning

confidence: 99%

Phenytoin Effects on Proliferation and Induction of IL1<i>β</i> and PGE2 in Pediatric and Adults’ Gingival Fibroblasts

Vahabi¹,

Moslemi²,

Nazemisalman³

et al. 2014

OJST

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Background: Gingival Overgrowth (GO) is a well documented and unwanted side effect that occurs mainly as a result of certain antiseizure, phenytoin. The aim of this study was to compare the effect of phenytoin on proliferation and production of IL1β and PGE2 in cultured human gingival fibroblasts (HGF) of children and adults. Materials and Methods: Normal HGFs were obtained from 4 healthy children and 4 adult and then were cultured with phenytoin (20 mg/ml). MTT test was used to evaluate the proliferation and ELISA to determine the level of IL1β and PGE2 production by HGFs. Analysis of proliferation were assessed by Independent T-Test and ANOVA analysis was used to assess the level of IL1β and PGE2 production with an a error level less than 0.05. Results: The proliferation of HGF was not affected significantly by phenytoin in both cultured fibroblast sources (P > 0.05). Phenytoin induced a significantly higher formation of IL1β and PGE2 in child's HGFs as compared to adult's HGFs (P < 0.05). Conclusion: The results suggest that different inflammatory responses and cytokine formation by child's and adult's HGFs are the probable key elements that cause different reactions of phenytoin therapy. More advanced and systematic studies are needed to verify these findings.

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Section: Discussionmentioning

confidence: 99%

Phenytoin Effects on Proliferation and Induction of IL1<i>β</i> and PGE2 in Pediatric and Adults’ Gingival Fibroblasts

Vahabi¹,

Moslemi²,

Nazemisalman³

et al. 2014

OJST

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“…As noted below, deregulated cytokine balances may contribute more significantly to the development and maintenance of gingival overgrowth. Several studies more consistently show that cultured human gingival fibroblasts treated with phenytoin, cyclosporin A, and nifedipine increase production of fibroblast cytokines and prostaglandin E 2 (Lerner et al, 1992;Modéer et al, 1992aModéer et al, ,b, 2000Brunius et al, 1993Brunius et al, , 1996, although lymphocytes and macrophages may be important sources of these factors in vivo (Modéer et al, 1989).…”

Section: Direct Effects Of Phenytoin Cyclosporin and Nifedipine On mentioning

confidence: 98%

Connective Tissue Metabolism and Gingival Overgrowth

Trackman

Kantarcı

2004

Critical Reviews in Oral Biology & Medicine

135

152

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Gingival overgrowth occurs mainly as a result of certain anti-seizure, immunosuppressive, or antihypertensive drug therapies. Excess gingival tissues impede oral function and are disfiguring. Effective oral hygiene is compromised in the presence of gingival overgrowth, and it is now recognized that this may have negative implications for the systemic health of affected patients. Recent studies indicate that cytokine balances are abnormal in drug-induced forms of gingival overgrowth. Data supporting molecular and cellular characteristics that distinguish different forms of gingival overgrowth are summarized, and aspects of gingival fibroblast extracellular matrix metabolism that are unique to gingival tissues and cells are reviewed. Abnormal cytokine balances derived principally from lymphocytes and macrophages, and unique aspects of gingival extracellular matrix metabolism, are elements of a working model presented to facilitate our gaining a better understanding of mechanisms and of the tissue specificity of gingival overgrowth.

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Modification of inflammatory processes by phenobarbital in rats

et al. 1991

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Enzyme-inducing drugs such as phenobarbital (PB) increase serum concentrations of an acute-phase protein, alpha 1-acid glycoprotein (AGP), in man, dogs, and rats via an unknown mechanism. We studied the effects of PB on components of an acute inflammatory reaction in rats in order to determine if PB acts only on this biological marker of inflammation or is capable of altering the clinical course of inflammatory processes. Local carrageenan injection induces a similar time-dependent plantar edema and increases serum AGP levels in Sprague-Dawley (SD) and Dark Agouti (DA) rats. Pretreatment with PB for seven days modified neither parameter in SD rats while plantar edema was aggravated and serum AGP levels were increased in DA rats. The sedative-hypnotic properties of PB were not involved, since a single administration of this drug had no action in DA rats. On the other hand, chronic PB administration reduced the severity of an autoimmune disease, type II collagen-induced arthritis, in DA rats. These data indicate that PB, a potent inducer a cytochrome P-450-dependent enzymes, modifies the course of the inflammatory process. Preliminary results with macrophage transfer experiments suggest that this response to PB could be mediated by stimulated macrophages.

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Phenytoin induces interleukin-1 production in vitro

Cited by 15 publications

References 17 publications

Phenytoin Effects on Proliferation and Induction of IL1<i>β</i> and PGE2 in Pediatric and Adults’ Gingival Fibroblasts

Phenytoin Effects on Proliferation and Induction of IL1<i>β</i> and PGE2 in Pediatric and Adults’ Gingival Fibroblasts

Connective Tissue Metabolism and Gingival Overgrowth

Modification of inflammatory processes by phenobarbital in rats

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Phenytoin induces interleukin-1 production in vitro

Cited by 15 publications

References 17 publications

Phenytoin Effects on Proliferation and Induction of IL1&lt;i&gt;β&lt;/i&gt; and PGE2 in Pediatric and Adults’ Gingival Fibroblasts

Phenytoin Effects on Proliferation and Induction of IL1&lt;i&gt;β&lt;/i&gt; and PGE2 in Pediatric and Adults’ Gingival Fibroblasts

Connective Tissue Metabolism and Gingival Overgrowth

Modification of inflammatory processes by phenobarbital in rats

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Product

Resources

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Phenytoin Effects on Proliferation and Induction of IL1<i>β</i> and PGE2 in Pediatric and Adults’ Gingival Fibroblasts

Phenytoin Effects on Proliferation and Induction of IL1<i>β</i> and PGE2 in Pediatric and Adults’ Gingival Fibroblasts