2011
DOI: 10.4314/ijbcs.v4i6.64974
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Phenytoin-induced toxicity in the postnatal cerebellar development in rat: effect of calotropis procera on selective biochemical and haematological variables

Abstract: Phenytoin, an antiepileptic drug is used in managing seizures. Phenytoin-associated oxidative stress causes cellular damage by the generation of free radicals. Vitamin C, a standard antioxidant and Calotropis procera are believed to scavenge oxygen free radicals. The effect of C. procera extract on haematological and biochemical variables in an in-vivo model was studied. Pregnant rats were administered phenytoin (50 mg/kg body weight). Extracts of C. procera (300 mg/kg body weight) and vitamin C (200 mg/kg bod… Show more

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Cited by 4 publications
(3 citation statements)
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“…The human body has several mechanisms to counteract oxidative stress by producing antioxidants, which are either naturally produced in situ, or externally supplied through foods and/or supplements. These antioxidants act as free radical scavengers by preventing and repairing damages caused by ROS, and therefore can enhance the immune defenses and lower the risk of cancer and degenerative diseases (Imosemi et al, 2010). In the present study, cadmium induced oxidative stress as shown by significantly increased level of LPO and decreased level of SOD, CAT, GSH and GPx compared with control and Lycopersicon esculentum groups on day 21.…”
Section: Cerebellar Astrocyte Count Of Day 28 Pupssupporting
confidence: 48%
See 1 more Smart Citation
“…The human body has several mechanisms to counteract oxidative stress by producing antioxidants, which are either naturally produced in situ, or externally supplied through foods and/or supplements. These antioxidants act as free radical scavengers by preventing and repairing damages caused by ROS, and therefore can enhance the immune defenses and lower the risk of cancer and degenerative diseases (Imosemi et al, 2010). In the present study, cadmium induced oxidative stress as shown by significantly increased level of LPO and decreased level of SOD, CAT, GSH and GPx compared with control and Lycopersicon esculentum groups on day 21.…”
Section: Cerebellar Astrocyte Count Of Day 28 Pupssupporting
confidence: 48%
“…Ten (10) tablets of 100mg each (i.e. 1000mg) was dissolved in 2.5ml of tap water to a concentration of 2.5 mg/ml and then 0.5ml (200mg) was administered to the animals in group V(cadmium + Vitamin C) by using an oral cannula daily throughout gestation period till the postnatal day 21 of birthed pups (Imosemi et al, 2010;Uchendu, 2018).…”
Section: Standard Vitamin C Was Purchased From Kunlementioning
confidence: 99%
“…Calotropis procera leaf extract has been reported to posses antioxidant activity by increasing the glutathione levels and decreasing the rate at which lipid peroxidation occurred in the developing cerebellum (Imosemi et al, 2010), preventing delayed maturation of cells of the cerebellar cortex and depletion of Purkinje cells of the developing cerebellum in phenytoin-induced oxidative stress (Imosemi & Osinubi, 2011). And that the antioxidant property of Calotropis procera was comparable to standard antioxidants, vitamins C and E.…”
Section: Introductionmentioning
confidence: 91%