Phenytoin induced sinoatrial bradyarrhythmia in the perioperative period

Kakkar, Aanchal; Chilkoti, Gitanjali; Mohta, Medha; Sethi, Ashwani; Arora, Mansi

doi:10.4103/0019-5049.123347

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…The concomitant therapy can displace phenytoin from conventional protein carriers in vitro and in vivo. This interaction has also been reported before [18,19] and could lead to increased serum phenytoin concentrations. It has been recommended to monitor free phenytoin concentration to avoid any toxic reactions in patients, especially in hypo-albuminemic situations [18].…”

Section: Discussionsupporting

confidence: 76%

A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan

et al. 2022

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Purpose: Several studies have shown that polypharmacy is the main cause of drug interactions, and the prevalence and the level of the severity varied with the duration of stay in the hospital, sex and race of the patients. The aims of this investigation were to identify the drug-drug interactions in hospitalized pediatric patients associated with polypharmacy, and to categorize the drug interactions in pharmacokinetic or pharmacodynamic interactions according to their level of severity. Methods: A cross-sectional, prospective analytical study was performed at a pediatric tertiary care hospital in Lahore, Pakistan for the duration of 4 months, which included prescription orders for 300 patients. Data were collected from patient medical files about previous and current medication history. Drug interactions were analyzed using interaction checker on Medscape and categorized according to the severity levels. Results: Out of 300 patients, the occurrence of drug interactions was found in 157 (52.3%) patients, while in 143 (47.7%), no interaction was found. Among these interactions, 50.7% were pharmacodynamic interactions, and 49.30% were pharmacokinetic interactions. Eighty-one percent of prescription orders with drug interactions contained more than three drugs, and 11.9% of interactions were severe. The majority of interactions were of amikacin-vancomycin, piroxicam-captopril and captopril-ciprofloxacin. Conclusion: Most of the interactions were moderate among patients with multiple drug prescriptions. The drug interactions can be minimized by providing special patient monitoring and adequate management with prior knowledge of these drug interaction.

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Section: Discussionsupporting

confidence: 76%