Phenytoin induced severe agranulocytosis and hepatitis

Neki, N.S.; Shah, Dharmen

doi:10.3126/jcmc.v6i3.16703

Cited by 1 publication

(1 citation statement)

References 8 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, subjects presenting with alopecia during PHT therapy should be assessed for other clinical manifestations suggesting autoimmune diseases. There are two other cases in the literature with alopecia secondary to PHT-induced lupus erythematosus [ 77 , 78 ].…”

Section: Antiseizure Medicationsmentioning

confidence: 99%

Antiseizure Medication-Induced Alopecia: A Literature Review

et al. 2023

View full text Add to dashboard Cite

Background: Adverse effects of antiseizure medications (ASMs) remain one of the major causes of non-adherence. Cosmetic side effects (CSEs) are among the most commonly reported side effects of ASMs. In this context, alopecia is one of the CSEs that has a high intolerance rate leading to poor therapeutical compliance. Methods: We performed a literature review concerning alopecia as a secondary effect of ASMs. Results: There are 1656 individuals reported with ASM-induced alopecia. Valproate (983), lamotrigine (355), and carbamazepine (225) have been extensively reported. Other ASMs associated with alopecia were cenobamate (18), levetiracetam (14), topiramate (13), lacosamide (7), vigabatrin (6), phenobarbital (5), gabapentin (5), phenytoin (4), pregabalin (4), eslicarbazepine (3), brivaracetam (2), clobazam (2), perampanel (2), trimethadione (2), rufinamide (2), zonisamide (2), primidone (1), and tiagabine (1). There were no reports of oxcarbazepine and felbamate with drug-induced alopecia. Hair loss seen with ASMs was diffuse and non-scarring. Telogen effluvium was the most common cause of alopecia. A characteristic feature was the reversibility of alopecia after ASM dose adjustment. Conclusions: Alopecia should be considered one important adverse effect of ASMs. Patients reporting hair loss with ASM therapy should be further investigated, and specialist consultation is recommended.

show abstract

Section: Antiseizure Medicationsmentioning

confidence: 99%