Phenytoin-Induced Erythroderma

Abstract

Phenytoin is a frequently prescribed anticonvulsant/antiseizure drug due to its high efficacy. Erythroderma is an intense and widespread reddening of the skin due to inflammation which may often be associated with peeling of skin termed as exfoliative dermatitis. Erythroderma is a rare but severe Adverse Drug Reaction (ADR) of phenytoin. Here, we report a case of a patient who developed erythrodema during the treatment regimen including phenytoin prescribed for the treatment of alcoholic withdrawal seizures. ADR was confirmed by using the World Health Organization (WHO) and Naranjo's causality assessment scale. The erythroderma condition was managed clinically by withdrawing the causal medication and administration of anti-histamines and corticosteroids with other supportive therapy. This case explains the adverse drug reaction occurring drugs used for cure. Hence there is a strong need for a pharmacovigilance programme and its awareness all over the nation.

Association of HLA-B*51:01, HLA-B*55:01, CYP2C9*3, and Phenytoin-Induced Cutaneous Adverse Drug Reactions in the South Indian Tamil Population

“…The RegiSCAR criteria were used to diagnose DRESS and DHS, which included an acute skin rash with at least one internal organ lymphadenopathy; hematologic abnormalities, such as eosinophilia and atypical lymphocytosis; and fever [ 25 ]. Patients with erythematic inflammatory skin disease, scaling on the cutaneous surface of the skin, thickened skin, itching, swollen lymph nodes, fever, and fluid loss were considered as PHT-ED [ 31 ].…”

Implementing Hospital Pharmacy Service Guideline in Nepal: A Critical Analysis

“…However, PharmD graduates as first professional degree holders are also entitled clinical pharmacists. [8][9][10][11] Though the guideline elaborates on setting appropriate prices for therapeutic agents, there is a need for a uniform pricing policy for people so that patients can bear out-ofpocket expenses for the regular use of medicines. The continuous availability of medicines that are freely obtainable from the Government of Nepal must be assured by all government hospitals at any cost.…”

Cisplatin-Induced Peripheral Neuropathy: An Observational Descriptive Study

“…Adverse drug reactions are unwanted and noxious effects due to therapy which complicates the dis-ease burden (Rachana et al, 2019;Anusha et al, 2018). Adverse drug reactions may range from mild to severe and may increase the length of hospital stay (Chand et al, 2019;Voora et al, 2019). Peripheral neuropathy is outlined as a condition where the peripheral nerves such as motor, sensory and involuntary nerves get damaged (Kannarkat et al, 2008).…”