Phenytoin in traumatic brain injury

Hunt, Elizabeth A.

doi:10.1136/adc.86.1.62

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…16 This study, combined with evidence of efficacy in adults, has prompted the recommendation of phenytoin prophylaxis for children with moderate to severe blunt head trauma. [17][18][19] However, there has been no prospective, randomized, placebo-controlled trial of phenytoin for the prophylaxis of early posttraumatic seizures in children. A recent national practice parameter identified a need for research in this area.…”

Section: Introductionmentioning

confidence: 99%

A randomized, double-blinded, placebo-controlled trial of phenytoin for the prevention of early posttraumatic seizures in children with moderate to severe blunt head injury

Young

Okada

Sokolove

et al. 2004

Annals of Emergency Medicine

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Section: Introductionmentioning

confidence: 99%

A randomized, double-blinded, placebo-controlled trial of phenytoin for the prevention of early posttraumatic seizures in children with moderate to severe blunt head injury

Young

Okada

Sokolove

et al. 2004

Annals of Emergency Medicine

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“…These pharmacological and non-pharmacological interventions progress to minimize the extent of damage along the evolving process after HI brain injury [53,54,55,56,57,58]. …”

Section: Neuroprotective Therapiesmentioning

confidence: 99%

“…In these sense, up to the present moment, some of the most useful therapies have been appeared, such as N -acetylcysteine and allopurinol, magnesium sulfate, glutamate receptor blockers, erythropoietin and hypothermia [ 52 ]. These pharmacological and non-pharmacological interventions progress to minimize the extent of damage along the evolving process after HI brain injury [ 53 , 54 , 55 , 56 , 57 , 58 ].…”

Section: Neuroprotective Therapiesmentioning

confidence: 99%

Neuroprotective Therapies after Perinatal Hypoxic-Ischemic Brain Injury

et al. 2013

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Hypoxic-ischemic (HI) brain injury is one of the main causes of disabilities in term-born infants. It is the result of a deprivation of oxygen and glucose in the neural tissue. As one of the most important causes of brain damage in the newborn period, the neonatal HI event is a devastating condition that can lead to long-term neurological deficits or even death. The pattern of this injury occurs in two phases, the first one is a primary energy failure related to the HI event and the second phase is an energy failure that takes place some hours later. Injuries that occur in response to these events are often manifested as severe cognitive and motor disturbances over time. Due to difficulties regarding the early diagnosis and treatment of HI injury, there is an increasing need to find effective therapies as new opportunities for the reduction of brain damage and its long term effects. Some of these therapies are focused on prevention of the production of reactive oxygen species, anti-inflammatory effects, anti-apoptotic interventions and in a later stage, the stimulation of neurotrophic properties in the neonatal brain which could be targeted to promote neuronal and oligodendrocyte regeneration.

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Epilepsy

2006

Wiley Handbook of Current and Emerging Drug Therapies

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Phenytoin in traumatic brain injury

Cited by 5 publications

References 12 publications

A randomized, double-blinded, placebo-controlled trial of phenytoin for the prevention of early posttraumatic seizures in children with moderate to severe blunt head injury

A randomized, double-blinded, placebo-controlled trial of phenytoin for the prevention of early posttraumatic seizures in children with moderate to severe blunt head injury

Neuroprotective Therapies after Perinatal Hypoxic-Ischemic Brain Injury

Epilepsy

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