Phenytoin for the prevention of motion sickness

Managing motion sickness

“…33 At the dose that is appropriate for treatment of epilepsy (approx 4-7 mg/kg daily for adults) the adverse effects of phenytoin are well known, including nausea, dizziness, constipation, mood changes, and blood dyscrasias. However, the doses required to prevent motion sickness would be smaller (previous studies used from 200 mg up to levels used for anticonvulsant treatment) and less frequent, which may be more tolerable.…”

Epitaph for the EBM in action series

“…This issue of the Journal https://doi.org/10.5694/j.1326-5377.2003.tb05362.x features the last article of the EBM in action series, 1 conceived to show how clinicians can effectively look for the best available evidence to answer clinical questions. In the current medical climate, clinicians clearly need systems to obtain the best available evidence, and the responsibility for creating these systems falls on both individual clinicians and the organisations for which they work 2 .…”