Phenylthiourea and Endemic Goitre

Luca, Federico de; Cramarossa, L

doi:10.1016/s0140-6736(65)92205-1

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…Lack of PTC tasting ability seems to be more frequent among athyroid cretins and their normal parents and siblings than in the general population [11,23]. A higher ratio of tasters has been reported among subjects showing toxic diffuse goitre than among normal subjects [5].…”

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confidence: 96%

“…Associations have been de m onstrated between the PTC-taster phenotype and thyroid patho logy. However, there is no consensus of opinion as to whether non tasters of PTC run a greater risk than tasters of developing nodular goitre [3,5,7,10,15,16]. Lack of PTC tasting ability seems to be more frequent among athyroid cretins and their normal parents and siblings than in the general population [11,23].…”

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confidence: 99%

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Phenylthiocarbamide Tasting Ability among Lapps and Finns

Eriksson¹,

Fellman²,

Forsius³

et al. 1970

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Using serial dilutions in the sorting test the taste thresholds for phenylthiocarbamide (PTC) were determined in Lapp populations in the region of Inari (Enare) in NE Finland and in unrelated Finns whose parents mainly came from the two northernmost Finnish counties, Lapland and Oulu (Uleåborg). A high frequency of non-tasters was noted among the highly related Skolt Lapp populations both at Sevettijärvi and Nellim, 28.3 and 29.7% respectively. The frequency of non-tasters among the Nellim Fisher Lapps was low, 10.5%, which is in good agreement with earlier measurements of taste sensitivity to PTC among Lapps.The frequency of non-tasters among the Finns was 22.1%. The frequency of PTC non-tasters among the Finns in North Finland seems to be lower than the figures reported by other authors for the Finns in South Finland. In all the populations studied a higher frequency of non-tasters and a lower average taste sensitivity for PTC were observed among males than among females. The Skolt males showed a marked reduction of the PTC taste sensitivity with age.

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confidence: 96%

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confidence: 99%

Phenylthiocarbamide Tasting Ability among Lapps and Finns

Eriksson¹,

Fellman²,

Forsius³

et al. 1970

Hum Hered

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“…In the past the association of phenylthiocarbamide (PTC) taste sensitiv ity with goitre has been studied, but the re suits have been inconclusive since the first report of an excess of non-tasters among subjects with adenomatous goitre [Harris et al, 1949]. Most of the later studies could not confirm the association of PTC taste sensitivity with endemic goitre [Brand, 1963;Hollingworth, 1963;Covarrubias et al, 1965;de Luca and Cramarossa, 1965;Malamos et al, 1966;Paolucci et al, 1971;Mendez et al, 1972], though positive asso ciations have ben reported [Kitchin et al, 1959;Azevedo et al, 1965].…”

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confidence: 99%

Study of Possible Genetic Predisposition to Endemic Goitre among the Fur and Baggara Tribes of the Sudan

1988

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The overall prevalence rate of endemic goitre among the Fur and Baggara tribes of Western Sudan was found to be 74%. Family studies in 60 nuclear families showed a significantly higher incidence of endemic goitre among the offspring of affected parents than among the offspring of normal parents. This suggests a possible genetic predisposition to endemic goitre. The proportion of phenylthiocarbamide (PTC) non-tasters was found to be 13% among the goitrous subjects compared to 17.5% among the non-goitrous subjects. However, the association with PTC as well as with 6 bloodgenetic markers, was not statistically significant.

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“…This fact has not been confirmed though there are indica tions of a greater risk for nodular goiter for individuals who are non-tasters [2,6,9], Taste sensitivity for PTC is also important in anthropological studies because of racial differences in the gene frequency. Thus, Eriksson et al [4] reported non-taster frequencies of 28.3, 29.7, 10.5, and 22.1% among dif ferent groups (Lapps and Finns) in Finland.…”

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Genetic Variation in Nigeria

Scott-Emuakpor¹,

Uviovo²,

Warren³

1975

Hum Hered

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Phenylthiourea (PTC) taste sensitivity thresholds have been measured for 2,013 Nigerians using a modified sorting technique. The frequency of non-tasters was observed to be 12.5% and the t gene frequency was 0.354. There was a significant difference between the sexes at the 0.01 level for the overall population. However, when the data are analyzed according to the geographical origin of the subject, the sex difference is found only in one of three geographical regions. Also, there may be geographical influences on PTC taste sensitivity, although this was not statistically significant. The estimates reported in this population differ considerably from some of the previously published estimates for black populations.

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Phenylthiourea and Endemic Goitre

Cited by 7 publications

References 15 publications

Phenylthiocarbamide Tasting Ability among Lapps and Finns

Phenylthiocarbamide Tasting Ability among Lapps and Finns

Study of Possible Genetic Predisposition to Endemic Goitre among the Fur and Baggara Tribes of the Sudan

Genetic Variation in Nigeria

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