Phenylpropanoids and tetrahydrofuran lignans from Piper solmsianum

Martins, Roberto Carlos Campos; Latorre, Leandro Ribeiro; Sartorelli, Patrı́cia; Kato, Massuo Jorge

doi:10.1016/s0031-9422(00)00295-8

Cited by 58 publications

(48 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A positive correlation between the production of phenylpropanoid (eg. elemicin, myristicin, and sarisan) and lignans/neolignans such as in case of P. regnellii 9 and P. solmsianum 12,23 was observed. In P. aduncum, which has the antifungal chromenes as major compound, the phenylpropanoid dillapiol has been detected as major constituent in the Amazonian species 4 but not in specimens occurring in southern region of Brazil.…”

Section: Resultsmentioning

confidence: 98%

Composition and antifungal activity of essential oils from Piper aduncum, Piper arboreum and Piper tuberculatum

Navickiene¹,

Morandim²,

Alécio³

et al. 2006

Quím. Nova

Self Cite

View full text Add to dashboard Cite

Recebido em 23/2/05; aceito em 16/9/05; publicado na web em 14/3/06The composition of essential oils from leaves, stems and fruits of Piper aduncum, P. arboreum and P. tuberculatum was examined by means of GC-MS and antifungal assay. There was a predominance of monoterpenes in P. aduncum and P. tuberculatum and of sesquiterpenes in P. arboreum. P. aduncum showed the richest essential oil composition, including linalool. The essential oils from fruits of P. aduncum and P. tuberculatum showed the highest antifungal activity with the MIC of 10 µg as determined against Cladosporium cladosporioides and C. sphaerospermum, respectively. This is the first report of the composition of essential oils from P. tuberculatum.

show abstract

Section: Resultsmentioning

confidence: 98%

Composition and antifungal activity of essential oils from Piper aduncum, Piper arboreum and Piper tuberculatum

Navickiene¹,

Morandim²,

Alécio³

et al. 2006

Quím. Nova

Self Cite

View full text Add to dashboard Cite

show abstract

“…Phytochemical studies revealed the presence of monoterpenes, sesquiterpenes, arylpropanoids, phenylpropanoids, lignans and neolignans, most of which showing biological activity against bacteria, fungus and the trypomastigote form of Trypanossoma cruzi (Moreira et al 1995;Martins et al 2000;Campos et al 2005;2007).…”

Section: Introductionmentioning

confidence: 99%

In vitro morphogenesis and cell suspension culture establishment in Piper solmsianum C. DC. (Piperaceae)

et al. 2009

View full text Add to dashboard Cite

RESUMO -(Morfogênese in vitro e estabelecimento de culturas de suspensão celular em Piper solmsianum C. DC. (Piperaceae)). Piper solmsianum é uma espécie herbácea do sudeste brasileiro onde vários compostos biologicamente ativos já foram identificados. O objetivo deste trabalho foi estabelecer suspensões celulares nesta espécie. Para tanto, foram utilizados explantes de pecíolos e folhas, retirados de plântulas cultivadas in vitro, os quais foram submetidos a diferentes combinações de reguladores de crescimento (AIA, ANA, 2,4-D e BAP). Foi obtida a neo-formação de raízes e brotos, estes últimos através do processo de organogênese indireta evidenciada por estudos histológicos. Para a indução e crescimento dos calos, foram avaliados, além das diferentes combinações de reguladores de crescimento, a suplementação ao meio de cultura de carvão ativado (1,5 mg.l -1 ) e o regime de luz. Culturas mantidas na luz, em meio de cultura suplementado com 0,2 mg.l -1 2,4-D e 2 mg.l -1 BAP e sem carvão ativado, resultaram em maior crescimento (massa fresca) dos calos. A partir destes calos, foram obtidas suspensões celulares, cuja dinâmica de crescimento e acúmulo de metabólitos foi estudado. Os resultados obtidos deverão ser utilizados para a caracterização de rotas biosintéticas em culturas in vitro em P. solmsianum. Palavras-chave: calogênese, morfogênese, pariparoba, reguladores de crescimento, suspensões celulares ABSTRACT -(In vitro morphogenesis and cell suspension culture establishment in Piper solmsianum C. DC. (Piperaceae)).Piper solmsianum is a shrub from Southeast Brazil in which many biologically active compounds were identified. The aim of this work was to establish a cell suspension culture system for this species. With this in mind, petiole and leaf explants obtained from in vitro plantlets were cultured in the presence of different plant growth regulator combinations (IAA, NAA, 2,4-D and BA). Root and indirect shoot adventitious formation, detected by histological analysis, was observed. Besides the different combinations of plant growth regulators, light regime and the supplement of activated charcoal (1.5 mg.l -1 ) were tested for callus induction and growth. Cultures maintained in light, on a 0.2 mg.l -1 2,4-D and 2 mg.l -1 BA supplemented medium, and in the absence of activated charcoal, showed the highest calli fresh matter increment. From a callus culture, cell suspension cultures were established and their growth and metabolite accumulation studied. The achieved results may be useful for further characterization of the activated secondary metabolites pathways in in vitro systems of P. solmsianum.

show abstract

mentioning

confidence: 99%

“…In contrast, phytochemical studies indicated the presence of aliphatic hydrocarbons, monoterpenes, sesquiterpenes, arylpropanoids and neolignans. [30][31][32] Recently, we have demonstrated that the fractions and some pure compounds (lignans) from the leaves of this plant exhibit significant activity against Gram-positive bacteria. 33) The current study extends our previous work on the biological properties of P. solmsianum and describes the in vitro antifungal activity of extracts, fractions and pure compounds against a panel of opportunistic pathogenic fungi using the agar dilution method.…”

mentioning

confidence: 99%

Evaluation of Antifungal Activity of Piper solmsianum C. DC. var. solmsianum (Piperaceae)

Campos

Filho

Silva

et al. 2005

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

The incidence of opportunistic fungal infections in immunocompromised patients, such as those undergoing treatment with immunosuppressive drugs, intensive chemotherapy, AIDS patients and neonates, is increasing at an alarming rate. 1,2) These mycoses are very difficult to eradicate, and present an enormous challenge for healthcare providers. 3,4) The diversity of plant species in Brazil, together with their known ethnopharmacological uses, creates enormous potential for finding new structures with antifungal properties. 5,6) The Piperaceae is a vast family of plants, which has been extensively used for medicinal purposes.7) It comprises about 10 genus and approximately 2000 species, most of them herbaceous, 8) which are found mainly in tropical areas. Piper and Peperomia, the two greatest genera of the family, are well-represented in the Brazilian flora. 9)Within the Piperaceae family, the genus Piper has over 700 species, distributed throughout the tropical and subtropical regions of the world. Its phytochemistry has been object of extensive reviews. 10,11) With regard to the ethnopharmacological information, while the pungent and aromatic fruits of some species of Piper are used as spices, most of them find wide application in traditional systems of medicine 10,11) as insecticides, 7,[12][13][14] antivirals, 15,16) antimicrobials [17][18][19][20][21] and particularly antifungals. [22][23][24][25][26][27][28] These biological properties have been attributed to the presence of lignans and/or amides, such as alkyl or olefinic isobutylamides, 7,23,29) flavonoids, kawa-lactones, butenolides and cyclohexane epoxides, among others. 10)Among the different species of Piper growing in Brazil, Piper solmsianum (syn. P. leucathum or P. santosanum) known popularly as "pariparoba", is a shrub that measures 1-3 m. There are few reports on the chemical or biological studies of this plant. In contrast, phytochemical studies indicated the presence of aliphatic hydrocarbons, monoterpenes, sesquiterpenes, arylpropanoids and neolignans. [30][31][32] Recently, we have demonstrated that the fractions and some pure compounds (lignans) from the leaves of this plant exhibit significant activity against Gram-positive bacteria. 33)The current study extends our previous work on the biological properties of P. solmsianum and describes the in vitro antifungal activity of extracts, fractions and pure compounds against a panel of opportunistic pathogenic fungi using the agar dilution method. MATERIALS AND METHODS Plant MaterialPiper solmsianum C. DC. var. solmsianum (Piperaceae) was collected in May, 2001, in Ponta Grossa, State of Paraná, Brazil, and identified by Dr. Elsie Franklin Guimarães (Rio de Janeiro Botanic Museum Herbarium). A voucher specimen was deposited in the same herbarium under the number RB 368597.Phytochemical Analyses Air-dried leaves (1.36 kg) of P. solmsianum var. solmsianum were cut into small pieces and macerated at room temperature for one week in methanol. After filtration, the solvent was removed by rotary evaporat...

show abstract

Phenylpropanoids and tetrahydrofuran lignans from Piper solmsianum

Cited by 58 publications

References 15 publications

Composition and antifungal activity of essential oils from Piper aduncum, Piper arboreum and Piper tuberculatum

Composition and antifungal activity of essential oils from Piper aduncum, Piper arboreum and Piper tuberculatum

In vitro morphogenesis and cell suspension culture establishment in Piper solmsianum C. DC. (Piperaceae)

Evaluation of Antifungal Activity of Piper solmsianum C. DC. var. solmsianum (Piperaceae)

Contact Info

Product

Resources

About