Abstract:Objective: Novel anticancer agents were designed to be synthesized comprising the essential features for anticancer activity considering Leucettamine B as a lead compound. Method: 3-Phenyl-2-thioxoimidazolidin-4-one 1 has been utilized for synthesis of various fused pyrrolo[1,2-e]imidazole 4, 8a,b, 11, 14, 16, 18, 20, 21, 23, 25 analogues through different chemical reactions. Results: Structures of these compounds were confirmed by spectral and elemental analyses Thirteen of the newly synthesized compounds wer… Show more
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