Phenylboronic acid-conjugated chitosan nanoparticles for high loading and efficient delivery of curcumin

Wang, Jun; Liu, Leyna G.; Jiao, Wen-Qiao; Yang, Hua; Liu, Jing; Liu, Dahai

doi:10.1016/j.carbpol.2020.117497

Cited by 58 publications

(38 citation statements)

References 31 publications

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“…When the mass ratio of OSAP to curcumin increased from 5:1 to 40:1, the weight of encapsulated curcumin in OSAP micelles was slightly improved, although the weight of carriers drastically increased, which caused a reduction of LC. The results were similar to those previous studies 26,57,59,60 . Therefore, the mass ratio of OSAP to curcumin of 10:1 was selected as optimal mass ratio for preparing Cur‐OSAP micelles in further experiments.…”

Section: Resultssupporting

confidence: 89%

Fabrication and characterization of octenyl succinic anhydride modified pullulan micelles for encapsulating curcumin

et al. 2021

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BACKGROUND Curcumin has become increasingly popular in functional foods and beverages field as a result of its high biological activity. Nevertheless, the application of curcumin is usually limited by its poor water solubility, low absorption, rapid metabolism and instability. Accordingly, the development of an appropriate wall material is crucial for its effective use. In the present study, curcumin‐octenyl succinic anhydride modified pullulan (Cur‐OSAP) micelles were successfully prepared by an anti‐solvent co‐precipitation method. RESULTS Octenyl succinic anhydride modified pullulan (OSAP) micelles exhibited the highest encapsulation efficiency (57.31%) and loading capacity (5.73%) of curcumin when the mass ratio of OSAP to curcumin was 10:1 and the degree of substitution of OSAP was 0.0469, at which point Cur‐OSAP micelles formed via hydrogen binding and hydrophobic interactions, as confirmed by Fourier transform infrared and fluorescence techniques. The transmission electron microscopy results showed that the Cur‐OSAP micelles were roughly spherical in shape with diameters in the approximate range 30–60 nm. CONCLUSION The encapsulation of OSAP greatly improved photostability and sustained release properties of curcumin in Cur‐OSAP micelles. These findings suggest that OSAP can be used as a carrier to encapsulate and protect hydrophobic food ingredients. © 2021 Society of Chemical Industry.

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Section: Resultssupporting

confidence: 89%

Fabrication and characterization of octenyl succinic anhydride modified pullulan micelles for encapsulating curcumin

et al. 2021

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“…The plateau was almost reached at 6.5 h and totally 91.18% of GA was released within 10.5 h. DGA without H 2 O 2 trigger showed no GA release. Compared with other ROS responsive phenylboronic acid-conjugated materials whose response range of H 2 O 2 were roughly 0.1 mM–5 mM [ 45 , [62] , [63] , [64] , [65] ], the H 2 O 2 sensitivity of DGA prepared by us was consistent with that reported in literature. In summary, DGA could respond to 1 mM H 2 O 2 to release drugs.…”

Section: Resultssupporting

confidence: 88%

ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation

Jin

Zhu

Ling

et al. 2023

Bioactive Materials

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“…Besides protective purposes, imine bonds are often reported for the cross-linking of CS chains. Glu is the most common CS cross-linker, leading to the stabilization of CS nanoparticles (NPs) ( Figure 6 , right circle) [ 6 , 51 ]. More specifically, Glu can also be exploited as a simple linker for the conjugation of CS to another polymer containing amino groups, such as polyacrylamide block copolymer [ 78 ].…”

Section: Strategies For Covalent Functionalizationmentioning

confidence: 99%

“…For both native CS and its derivatives, 1 H NMR is usually performed in pure D 2 O [ 17 , 51 , 99 ] or in a mixture of D 2 O and acidic deuterated solvent to improve CS solubility. Deuterated hydrogen chloride solution (35%) (DCl) [ 57 , 73 , 77 ] or deuterated acetic acid (AcOD) [ 34 , 62 ] are commonly used.…”

Section: Characterization Of Cs-based Materialsmentioning

confidence: 99%

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Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

2021

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Chitosan (CS) is a natural biopolymer that has gained great interest in many research fields due to its promising biocompatibility, biodegradability, and favorable mechanical properties. The versatility of this low-cost polymer allows for a variety of chemical modifications via covalent conjugation and non-covalent interactions, which are designed to further improve the properties of interest. This review aims at presenting the broad range of functionalization strategies reported over the last five years to reflect the state-of-the art of CS derivatization. We start by describing covalent modifications performed on the CS backbone, followed by non-covalent CS modifications involving small molecules, proteins, and metal adjuvants. An overview of CS-based systems involving both covalent and electrostatic modification patterns is then presented. Finally, a special focus will be given on the characterization techniques commonly used to qualify the composition and physical properties of CS derivatives.

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Phenylboronic acid-conjugated chitosan nanoparticles for high loading and efficient delivery of curcumin

Cited by 58 publications

References 31 publications

Fabrication and characterization of octenyl succinic anhydride modified pullulan micelles for encapsulating curcumin

Fabrication and characterization of octenyl succinic anhydride modified pullulan micelles for encapsulating curcumin

ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation

Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

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